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Current Allergy and Asthma Reports

Erschienen in:

01.07.2020 | Pediatric Allergy and Immunology (W Dolen, Section Editor)

Monoclonal Antibody Therapy in Childhood Asthma

verfasst von: Katherine L. Tison, Meera Patrawala, Michael S. Blaiss

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 7/2020

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Abstract

Purpose of Review

There has been an explosion of monoclonal antibodies in the treatment of severe uncontrolled adult asthma. Studies have now been published in severe pediatric asthma. There are numerous questions that need to be answered in determining whether these modalities are appropriate and safe in children.

Recent Findings

This is a narrative review examining the latest pediatric literature on monoclonal antibodies, both approved and in the pipeline, for uncontrolled asthma. Presently, all of the biologics are positioned to treat patients with underlying type 2 high disease. Two monoclonal antibodies are approved for children 6 years of age and older, omalizumab and mepolizumab, with more likely approved in the near future.

Summary

The effect of these agents in controlling severe pediatric asthma is promising. Data is limited to long-term efficacy and safety, and whether any agent has an effect on the natural history of asthma.

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Titel: Monoclonal Antibody Therapy in Childhood Asthma
verfasst von: Katherine L. Tison
Meera Patrawala
Michael S. Blaiss
Publikationsdatum: 01.07.2020
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 7/2020
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-020-00919-3

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Springer Medizin

Monoclonal Antibody Therapy in Childhood Asthma

Abstract

Purpose of Review

Recent Findings

Summary

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Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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