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01.10.2013 | Psychiatry and Preclinical Psychiatric Studies - Original Article

MR and GR functional SNPs may modulate tobacco smoking susceptibility

verfasst von: Diego L. Rovaris, Nina R. Mota, Lucas A. de Azeredo, Renata B. Cupertino, Guilherme P. Bertuzzi, Evelise R. Polina, Verônica Contini, Gustavo L. Kortmann, Eduardo S. Vitola, Eugenio H. Grevet, Rodrigo Grassi-Oliveira, Sidia M. Callegari-Jacques, Claiton H. D. Bau

Erschienen in: Journal of Neural Transmission | Ausgabe 10/2013

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Abstract

A number of studies have demonstrated that stress is involved in all aspects of smoking behavior, including initiation, maintenance and relapse. The mineralocorticoid (MR) and glucocorticoid (GR) receptors are expressed in several brain areas and play a key role in negative feedback of the hypothalamic–pituitary–adrenal (HPA) axis. As nicotine increases the activation of the HPA axis, we wondered if functional SNPs (single nucleotide polymorphisms) in MR and GR coding genes (NR3C2 rs5522 and NR3C1 rs6198, respectively) may be involved in smoking susceptibility. The sample included 627 volunteers, of which 514 were never-smokers and 113 lifetime smokers. We report an interaction effect between rs5522 and rs6198 SNPs. The odds ratio (OR) for the presence of the NR3C2 rs5522 Val allele in NR3C1 rs6198 G carriers was 0.18 (P = 0.007), while in rs6198 G noncarriers the OR was 1.83 (P = 0.027). We also found main effects of the NR3C1 rs6198 G allele on number of cigarettes smoked per day (P = 0.027) and in total score of the Fagerström Test for Nicotine Dependence (P = 0.007). These findings are consistent with a possible link between NR3C2 and NR3C1 polymorphisms and smoking behavior and provide a first partial replication for a nominally significant GWAS finding between NR3C2 and tobacco smoking.

al’Absi M, Hatsukami D, Davis GL (2005) Attenuated adrenocorticotropic responses to psychological stress are associated with early smoking relapse. Psychopharmacology 181(1):107–117PubMedCrossRef

Arai K, Nakagomi Y, Iketani M, Shimura Y, Amemiya S, Ohyama K et al (2003) Functional polymorphisms in the mineralocorticoid receptor and amirolide-sensitive sodium channel genes in a patient with sporadic pseudohypoaldosteronism. Hum Genet 112(1):91–97PubMedCrossRef

Bamberger CM, Bamberger AM, Wald M, Chrousos GP, Schulte HM (1997) Inhibition of mineralocorticoid activity by the beta-isoform of the human glucocorticoid receptor. J Steroid Biochem Mol Biol 60(1–2):43–50PubMedCrossRef

Barr RS, Pizzagalli DA, Culhane MA, Goff DC, Evins AE (2008) A single dose of nicotine enhances reward responsiveness in nonsmokers: implications for development of dependence. Biol Psychiatry 63(11):1061–1065PubMedCrossRef

Berrettini W, Yuan X, Tozzi F, Song K, Francks C, Chilcoat H et al (2008) Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry 13(4):368–373PubMedCrossRef

Biederman J, Monuteaux MC, Mick E, Spencer T, Wilens TE, Silva JM et al (2006) Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study. Psychol Med 36(2):167–179PubMedCrossRef

Bogdan R, Perlis RH, Fagerness J, Pizzagalli DA (2010) The impact of mineralocorticoid receptor ISO/VAL genotype (rs5522) and stress on reward learning. Genes Brain Behav 9(6):658–667PubMed

Bouma EM, Riese H, Nolte IM, Oosterom E, Verhulst FC, Ormel J et al (2011) No associations between single nucleotide polymorphisms in corticoid receptor genes and heart rate and cortisol responses to a standardized social stress test in adolescents: the TRAILS study. Behav Genet 41(2):253–261PubMedCrossRef

Bruijnzeel AW (2012) Tobacco addiction and the dysregulation of brain stress systems. Neurosci Biobehav Rev 36(5):1418–1441PubMedCrossRef

Contini V, Victor MM, Bertuzzi GP, Salgado CA, Picon FA, Grevet EH et al (2012) No significant association between genetic variants in 7 candidate genes and response to methylphenidate treatment in adult patients with ADHD. J Clin Psychopharmacol 32(6):820–823PubMedCrossRef

DeRijk RH (2009) Single nucleotide polymorphisms related to HPA axis reactivity. NeuroImmunomodulation 16(5):340–352PubMedCrossRef

DeRijk RH, Schaaf MJ, Turner G, Datson NA, Vreugdenhil E, Cidlowski J et al (2001) A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis. J Rheumatol 28(11):2383–2388PubMed

DeRijk RH, Wust S, Meijer OC, Zennaro MC, Federenko IS, Hellhammer DH et al (2006) A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness. J Clin Endocrinol Metab 91(12):5083–5089PubMedCrossRef

Diekhof EK, Falkai P, Gruber O (2008) Functional neuroimaging of reward processing and decision-making: a review of aberrant motivational and affective processing in addiction and mood disorders. Brain Res Rev 59(1):164–184PubMedCrossRef

Falba T, Teng HM, Sindelar JL, Gallo WT (2005) The effect of involuntary job loss on smoking intensity and relapse. Addiction 100(9):1330–1339PubMedCrossRef

First MB, Spitzer RL, Gibbon M, Williams JBW (2002) Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P). Biometrics Research, New York State Psychiatric Institute, New York

Fortier ME, Sengupta SM, Grizenko N, Choudhry Z, Thakur G, Joober R (2013) Genetic evidence for the association of the hypothalamic-pituitary-adrenal (HPA) axis with ADHD and methylphenidate treatment response. Neuromol Med 15(1):122–132CrossRef

Gilbert DG, Meliska CJ, Williams CL, Jensen RA (1992) Subjective correlates of cigarette-smoking-induced elevations of peripheral beta-endorphin and cortisol. Psychopharmacology 106(2):275–281PubMedCrossRef

INCA (2011) A situação do tabagismo no Brasil: dados dos inquéritos do Sistema Internacional de Vigilância, da Organização Mundial da Saúde, realizados no Brasil, entre 2002 e 2009/Instituto Nacional de Câncer José Alencar Gomes da Silva. INCA, Rio de Janeiro

Jamal M, Does AJ, Penninx BW, Cuijpers P (2011) Age at smoking onset and the onset of depression and anxiety disorders. Nicotine Tob Res 13(9):809–819PubMedCrossRef

Joels M, Karst H, DeRijk R, de Kloet ER (2008) The coming out of the brain mineralocorticoid receptor. Trends Neurosci 31(1):1–7PubMedCrossRef

Kessler RC, Adler L, Ames M, Demler O, Faraone S, Hiripi E et al (2005) The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population. Psychol Med 35(2):245–256PubMedCrossRef

Khaled SM, Bulloch AG, Williams JV, Hill JC, Lavorato DH, Patten SB (2012) Persistent heavy smoking as risk factor for major depression (MD) incidence–evidence from a longitudinal Canadian cohort of the National Population Health Survey. J Psychiatr Res 46(4):436–443PubMedCrossRef

Kirschbaum C, Wust S, Strasburger CJ (1992) ‘Normal’ cigarette smoking increases free cortisol in habitual smokers. Life Sci 50(6):435–442PubMedCrossRef

Klok MD, Vreeburg SA, Penninx BW, Zitman FG, de Kloet ER, DeRijk RH (2011) Common functional mineralocorticoid receptor polymorphisms modulate the cortisol awakening response: interaction with SSRIs. Psychoneuroendocrinology 36(4):484–494PubMedCrossRef

Kollins SH, McClernon FJ, Fuemmeler BF (2005) Association between smoking and attention-deficit/hyperactivity disorder symptoms in a population-based sample of young adults. Arch Gen Psychiatry 62(10):1142–1147PubMedCrossRef

Kortmann GL, Contini V, Bertuzzi GP, Mota NR, Rovaris DL, Paixao-Cortes VR et al (2012) The role of a mineralocorticoid receptor gene functional polymorphism in the symptom dimensions of persistent ADHD. Eur Arch Psychiatry Clin Neurosci. doi:10.1007/s00406-012-0321-z PubMed

Kumsta R, Entringer S, Koper JW, van Rossum EF, Hellhammer DH, Wust S (2007) Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress. Biol Psychiatry 62(8):863–869PubMedCrossRef

Kumsta R, Entringer S, Koper JW, van Rossum EF, Hellhammer DH, Wust S (2008) Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes. Biol Psychol 79(2):179–184PubMedCrossRef

Kuningas M, de Rijk RH, Westendorp RG, Jolles J, Slagboom PE, van Heemst D (2007) Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors. Neuropsychopharmacology 32(6):1295–1301PubMedCrossRef

Lahiri DK, Nurnberger JI (1991) A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 19(19):5444PubMedCrossRef

Liu W, Wang J, Sauter NK, Pearce D (1995) Steroid receptor heterodimerization demonstrated in vitro and in vivo. Proc Natl Acad Sci U S A 92(26):12480–12484PubMedCrossRef

Lutfy K, Aimiuwu O, Mangubat M, Shin CS, Nerio N, Gomez R et al (2012) Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors. J Neurochem 120(6):1108–1116PubMed

Mayhew KP, Flay BR, Mott JA (2000) Stages in the development of adolescent smoking. Drug Alcohol Depend 59(Suppl 1):S61–S81PubMedCrossRef

McEwen A, West R, McRobbie H (2008) Motives for smoking and their correlates in clients attending Stop Smoking treatment services. Nicotine Tob Res 10(5):843–850PubMedCrossRef

Mendelson JH, Sholar MB, Goletiani N, Siegel AJ, Mello NK (2005) Effects of low- and high-nicotine cigarette smoking on mood states and the HPA axis in men. Neuropsychopharmacology 30(9):1751–1763PubMedCrossRef

Mendelson JH, Goletiani N, Sholar MB, Siegel AJ, Mello NK (2008) Effects of smoking successive low- and high-nicotine cigarettes on hypothalamic-pituitary-adrenal axis hormones and mood in men. Neuropsychopharmacology 33(4):749–760PubMedCrossRef

Oakley RH, Cidlowski JA (2011) Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids. J Biol Chem 286(5):3177–3184PubMedCrossRef

Oitzl MS, Champagne DL, van der Veen R, de Kloet ER (2010) Brain development under stress: hypotheses of glucocorticoid actions revisited. Neurosci Biobehav Rev 34(6):853–866PubMedCrossRef

Oswald LM, Wong DF, McCaul M, Zhou Y, Kuwabara H, Choi L et al (2005) Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine. Neuropsychopharmacology 30(4):821–832PubMed

Polina ER, Contini V, Hutz MH, Bau CH (2009) The serotonin 2A receptor gene in alcohol dependence and tobacco smoking. Drug Alcohol Depend 101(1–2):128–131PubMedCrossRef

Richards JM, Stipelman BA, Bornovalova MA, Daughters SB, Sinha R, Lejuez CW (2011) Biological mechanisms underlying the relationship between stress and smoking: state of the science and directions for future work. Biol Psychol 88(1):1–12PubMedCrossRef

Rogausch A, Kochen MM, Meineke C, Hennig J (2007) Association between the BclI glucocorticoid receptor polymorphism and smoking in a sample of patients with obstructive airway disease. Addict Biol 12(1):93–99PubMedCrossRef

Savory JG, Prefontaine GG, Lamprecht C, Liao M, Walther RF, Lefebvre YA et al (2001) Glucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through alternative dimerization interfaces. Mol Cell Biol 21(3):781–793PubMedCrossRef

Siiskonen SJ, Visser LE, Tiemeier H, Hofman A, Lamberts SW, Uitterlinden AG et al (2009) BclI glucocorticoid receptor polymorphism and smoking in the general population. Addict Biol 14(3):349–355PubMedCrossRef

Sinha R (2008) Chronic stress, drug use, and vulnerability to addiction. Ann N Y Acad Sci 1141:105–130PubMedCrossRef

Sousa NO, Grevet EH, Salgado CA, Silva KL, Victor MM, Karam RG et al (2011) Smoking and ADHD: an evaluation of self medication and behavioral disinhibition models based on comorbidity and personality patterns. J Psychiatr Res 45(6):829–834PubMedCrossRef

Spijker AT, van Rossum EF, Hoencamp E, DeRijk RH, Haffmans J, Blom M et al (2009) Functional polymorphism of the glucocorticoid receptor gene associates with mania and hypomania in bipolar disorder. Bipolar Disord 11(1):95–101PubMedCrossRef

Spijker AT, Giltay EJ, van Rossum EF, Manenschijn L, DeRijk RH, Haffmans J et al (2011) Glucocorticoid and mineralocorticoid receptor polymorphisms and clinical characteristics in bipolar disorder patients. Psychoneuroendocrinology 36(10):1460–1469PubMedCrossRef

Steptoe A, Ussher M (2006) Smoking, cortisol and nicotine. Int J Psychophysiol 59(3):228–235PubMedCrossRef

Szczepankiewicz A, Leszczynska-Rodziewicz A, Pawlak J, Rajewska-Rager A, Dmitrzak-Weglarz M, Wilkosc M et al (2011) Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder. J Affect Disord 134(1–3):138–144PubMedCrossRef

Trapp T, Rupprecht R, Castren M, Reul JM, Holsboer F (1994) Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS. Neuron 13(6):1457–1462PubMedCrossRef

van Leeuwen N, Kumsta R, Entringer S, de Kloet ER, Zitman FG, DeRijk RH et al (2010) Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone. Psychoneuroendocrinology 35(3):339–349PubMedCrossRef

van Leeuwen N, Bellingrath S, de Kloet ER, Zitman FG, DeRijk RH, Kudielka BM et al (2011) Human mineralocorticoid receptor (MR) gene haplotypes modulate MR expression and transactivation: implication for the stress response. Psychoneuroendocrinology 36(5):699–709PubMedCrossRef

Wand GS, Oswald LM, McCaul ME, Wong DF, Johnson E, Zhou Y et al (2007) Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stress. Neuropsychopharmacology 32(11):2310–2320PubMedCrossRef

Wellman RJ, DiFranza JR, Savageau JA, Dussault GF (2004) Short term patterns of early smoking acquisition. Tob Control 13(3):251–257PubMedCrossRef

Wilkins JN, Carlson HE, Van Vunakis H, Hill MA, Gritz E, Jarvik ME (1982) Nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers. Psychopharmacology 78(4):305–308PubMedCrossRef

Wills TA, Sandy JM, Yaeger AM (2002) Stress and smoking in adolescence: a test of directional hypotheses. Health Psychol 21(2):122–130PubMedCrossRef

Winternitz WW, Quillen D (1977) Acute hormonal response to cigarette smoking. J Clin Pharmacol 17(7):389–397PubMedCrossRef

Titel: MR and GR functional SNPs may modulate tobacco smoking susceptibility
verfasst von: Diego L. Rovaris
Nina R. Mota
Lucas A. de Azeredo
Renata B. Cupertino
Guilherme P. Bertuzzi
Evelise R. Polina
Verônica Contini
Gustavo L. Kortmann
Eduardo S. Vitola
Eugenio H. Grevet
Rodrigo Grassi-Oliveira
Sidia M. Callegari-Jacques
Claiton H. D. Bau
Publikationsdatum: 01.10.2013
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 10/2013
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-1012-2

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