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Erschienen in: Journal of Neural Transmission 10/2013

01.10.2013 | Neurology and Preclinical Neurological Studies - Short communication

A preliminary method development study to identify potential stroke biomarkers in plasma using multiple chromatographies with nanoLC-ESIMS detection

verfasst von: Phanichand Kodali, Julio A. Landero-Figueroa, Joseph Caruso, Opeolu Adeoye

Erschienen in: Journal of Neural Transmission | Ausgabe 10/2013

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Abstract

Stroke is the leading cause of disability in the USA. Rapid, reliable diagnosis via a point-of-care blood test may facilitate earlier treatment to reduce disability. We have recently reported detailed methods of chromatographic separations of plasma samples coupled with nanoESI-ion trap a list of proteins which are viable candidates for further investigation as stroke biomarkers.
Literatur
Zurück zum Zitat Adeoye O, Hornung R, Khatri P, Kleindorfer D (2011) Recombinant tissue-type plasminogen activator use for ischemic stroke in the United States: a doubling of treatment rates over the course of 5 years. Stroke 42:1952–1955PubMedCrossRef Adeoye O, Hornung R, Khatri P, Kleindorfer D (2011) Recombinant tissue-type plasminogen activator use for ischemic stroke in the United States: a doubling of treatment rates over the course of 5 years. Stroke 42:1952–1955PubMedCrossRef
Zurück zum Zitat Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG (2002) Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. Mol Cell Proteomics 1:947–955PubMedCrossRef Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG (2002) Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. Mol Cell Proteomics 1:947–955PubMedCrossRef
Zurück zum Zitat Alvarez-Manilla G, Atwood J 3rd, Guo Y, Warren NL, Orlando R, Pierce M (2006) Tools for glycoproteomic analysis: size exclusion chromatography facilitates identification of tryptic glycopeptides with N-linked glycosylation sites. J Proteome Res 5:701–708PubMedCrossRef Alvarez-Manilla G, Atwood J 3rd, Guo Y, Warren NL, Orlando R, Pierce M (2006) Tools for glycoproteomic analysis: size exclusion chromatography facilitates identification of tryptic glycopeptides with N-linked glycosylation sites. J Proteome Res 5:701–708PubMedCrossRef
Zurück zum Zitat Anderson L (2005) Candidate-based proteomics in the search for biomarkers of cardiovascular disease. J Physiol 563:23–60PubMedCrossRef Anderson L (2005) Candidate-based proteomics in the search for biomarkers of cardiovascular disease. J Physiol 563:23–60PubMedCrossRef
Zurück zum Zitat Beamer NB, Coull BM, Clark WM, Briley DP, Wynn M, Sexton G (1998) Persistent inflammatory response in stroke survivors. Neurology 50:1722–1728PubMedCrossRef Beamer NB, Coull BM, Clark WM, Briley DP, Wynn M, Sexton G (1998) Persistent inflammatory response in stroke survivors. Neurology 50:1722–1728PubMedCrossRef
Zurück zum Zitat Di Napoli M, Papa F (2002) Inflammation, hemostatic markers, and antithrombotic agents in relation to long-term risk of new cardiovascular events in first-ever ischemic stroke patients. Stroke 33:1763–1771PubMedCrossRef Di Napoli M, Papa F (2002) Inflammation, hemostatic markers, and antithrombotic agents in relation to long-term risk of new cardiovascular events in first-ever ischemic stroke patients. Stroke 33:1763–1771PubMedCrossRef
Zurück zum Zitat Engstrom G, Hedblad B, Janzon L, Lindgarde F (2007) Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study. Eur J Cardiovasc Prev Rehabil 14:392–397PubMedCrossRef Engstrom G, Hedblad B, Janzon L, Lindgarde F (2007) Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study. Eur J Cardiovasc Prev Rehabil 14:392–397PubMedCrossRef
Zurück zum Zitat Gould DB, Phalan FC, van Mil SE, Sundberg JP, Vahedi K, Massin P, Bousser MG, Heutink P, Miner JH, Tournier-Lasserve E, John SW (2006) Role of COL4A1 in small-vessel disease and hemorrhagic stroke. N Engl J Med 354:1489–1496PubMedCrossRef Gould DB, Phalan FC, van Mil SE, Sundberg JP, Vahedi K, Massin P, Bousser MG, Heutink P, Miner JH, Tournier-Lasserve E, John SW (2006) Role of COL4A1 in small-vessel disease and hemorrhagic stroke. N Engl J Med 354:1489–1496PubMedCrossRef
Zurück zum Zitat Jood K, Danielson J, Ladenvall C, Blomstrand C, Jern C (2008) Fibrinogen gene variation and ischemic stroke. J Thromb Haemost 6:897–904PubMedCrossRef Jood K, Danielson J, Ladenvall C, Blomstrand C, Jern C (2008) Fibrinogen gene variation and ischemic stroke. J Thromb Haemost 6:897–904PubMedCrossRef
Zurück zum Zitat Kara I, Sazci A, Ergul E, Kaya G, Kilic G (2003) Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Brain Res Mol Brain Res 111:84–90PubMedCrossRef Kara I, Sazci A, Ergul E, Kaya G, Kilic G (2003) Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Brain Res Mol Brain Res 111:84–90PubMedCrossRef
Zurück zum Zitat Kim MH, Kang SY, Kim MC, Lee WI (2010) Plasma biomarkers in the diagnosis of acute ischemic stroke. Ann Clin Lab Sci 40:336–341PubMed Kim MH, Kang SY, Kim MC, Lee WI (2010) Plasma biomarkers in the diagnosis of acute ischemic stroke. Ann Clin Lab Sci 40:336–341PubMed
Zurück zum Zitat Kodali P, Jurkevica A, Landero J, Kuhlmann C, Caruso J, Adeoye O (2012) Multiple liquid chromatography separations and nanoESI-ion trap detection of plasma proteins in search of stroke biomarkers: a pilot study. J Sep Sci 35(17):2153–2161. doi:10.1002/jssc.201200216 PubMedCrossRef Kodali P, Jurkevica A, Landero J, Kuhlmann C, Caruso J, Adeoye O (2012) Multiple liquid chromatography separations and nanoESI-ion trap detection of plasma proteins in search of stroke biomarkers: a pilot study. J Sep Sci 35(17):2153–2161. doi:10.​1002/​jssc.​201200216 PubMedCrossRef
Zurück zum Zitat Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y (2007) A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction. Nat Genet 39:212–217PubMedCrossRef Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y (2007) A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction. Nat Genet 39:212–217PubMedCrossRef
Zurück zum Zitat Lecchi P, Gupte AR, Perez RE, Stockert LV, Abramson FP (2003) Size-exclusion chromatography in multidimensional separation schemes for proteome analysis. J Biochem Biophys Methods 56:141–152PubMedCrossRef Lecchi P, Gupte AR, Perez RE, Stockert LV, Abramson FP (2003) Size-exclusion chromatography in multidimensional separation schemes for proteome analysis. J Biochem Biophys Methods 56:141–152PubMedCrossRef
Zurück zum Zitat Meng R, Li ZY, Ji X, Ding Y, Meng S, Wang X (2011) Antithrombin III associated with fibrinogen predicts the risk of cerebral ischemic stroke. Clin Neurol Neurosurg 113:380–386PubMedCrossRef Meng R, Li ZY, Ji X, Ding Y, Meng S, Wang X (2011) Antithrombin III associated with fibrinogen predicts the risk of cerebral ischemic stroke. Clin Neurol Neurosurg 113:380–386PubMedCrossRef
Zurück zum Zitat Pieper R, Su Q, Gatlin CL, Huang ST, Anderson NL, Steiner S (2003) Multi-component immunoaffinity subtraction chromatography: an innovative step towards a comprehensive survey of the human plasma proteome. Proteomics 3:422–432PubMedCrossRef Pieper R, Su Q, Gatlin CL, Huang ST, Anderson NL, Steiner S (2003) Multi-component immunoaffinity subtraction chromatography: an innovative step towards a comprehensive survey of the human plasma proteome. Proteomics 3:422–432PubMedCrossRef
Zurück zum Zitat Reynolds MA, Kirchick HJ, Dahlen JR, Anderberg JM, McPherson PH, Nakamura KK, Laskowitz DT, Valkirs GE, Buechler KF (2003) Early biomarkers of stroke. Clin Chem 49:1733–1739PubMedCrossRef Reynolds MA, Kirchick HJ, Dahlen JR, Anderberg JM, McPherson PH, Nakamura KK, Laskowitz DT, Valkirs GE, Buechler KF (2003) Early biomarkers of stroke. Clin Chem 49:1733–1739PubMedCrossRef
Zurück zum Zitat Rifai N, Gillette MA, Carr SA (2006) Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat Biotechnol 24:971–983PubMedCrossRef Rifai N, Gillette MA, Carr SA (2006) Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat Biotechnol 24:971–983PubMedCrossRef
Zurück zum Zitat Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, Sorlie PD, Sotoodehnia N, Turan TN, Virani SS, Wong ND, Woo D, Turner MB (2012) Executive summary: heart disease and stroke statistics–2012 update: a report from the American Heart Association. Circulation 125:188–197PubMedCrossRef Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, Sorlie PD, Sotoodehnia N, Turan TN, Virani SS, Wong ND, Woo D, Turner MB (2012) Executive summary: heart disease and stroke statistics–2012 update: a report from the American Heart Association. Circulation 125:188–197PubMedCrossRef
Zurück zum Zitat Rothwell PM, Howard SC, Power DA, Gutnikov SA, Algra A, van Gijn J, Clark TG, Murphy MF, Warlow CP (2004) Fibrinogen concentration and risk of ischemic stroke and acute coronary events in 5113 patients with transient ischemic attack and minor ischemic stroke. Stroke 35:2300–2305PubMedCrossRef Rothwell PM, Howard SC, Power DA, Gutnikov SA, Algra A, van Gijn J, Clark TG, Murphy MF, Warlow CP (2004) Fibrinogen concentration and risk of ischemic stroke and acute coronary events in 5113 patients with transient ischemic attack and minor ischemic stroke. Stroke 35:2300–2305PubMedCrossRef
Zurück zum Zitat Saenger AK, Christenson RH (2010) Stroke biomarkers: progress and challenges for diagnosis, prognosis, differentiation, and treatment. Clin Chem 56:21–33PubMedCrossRef Saenger AK, Christenson RH (2010) Stroke biomarkers: progress and challenges for diagnosis, prognosis, differentiation, and treatment. Clin Chem 56:21–33PubMedCrossRef
Zurück zum Zitat Sazci A, Ergul E, Guzelhan Y, Kaya G, Kara I (2003) Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia. Brain Res Mol Brain Res 117:104–107PubMedCrossRef Sazci A, Ergul E, Guzelhan Y, Kaya G, Kara I (2003) Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia. Brain Res Mol Brain Res 117:104–107PubMedCrossRef
Zurück zum Zitat Tanne D, Benderly M, Goldbourt U, Boyko V, Brunner D, Graff E, Reicher-Reiss H, Shotan A, Mandelzweig L, Behar S (2001) A prospective study of plasma fibrinogen levels and the risk of stroke among participants in the bezafibrate infarction prevention study. Am J Med 111:457–463PubMedCrossRef Tanne D, Benderly M, Goldbourt U, Boyko V, Brunner D, Graff E, Reicher-Reiss H, Shotan A, Mandelzweig L, Behar S (2001) A prospective study of plasma fibrinogen levels and the risk of stroke among participants in the bezafibrate infarction prevention study. Am J Med 111:457–463PubMedCrossRef
Zurück zum Zitat Tirumalai RS, Chan KC, Prieto DA, Issaq HJ, Conrads TP, Veenstra TD (2003) Characterization of the low molecular weight human serum proteome. Mol Cell Proteomics 2:1096–1103PubMedCrossRef Tirumalai RS, Chan KC, Prieto DA, Issaq HJ, Conrads TP, Veenstra TD (2003) Characterization of the low molecular weight human serum proteome. Mol Cell Proteomics 2:1096–1103PubMedCrossRef
Zurück zum Zitat Whiteley W, Tseng MC, Sandercock P (2008) Blood biomarkers in the diagnosis of ischemic stroke: a systematic review. Stroke 39:2902–2909PubMedCrossRef Whiteley W, Tseng MC, Sandercock P (2008) Blood biomarkers in the diagnosis of ischemic stroke: a systematic review. Stroke 39:2902–2909PubMedCrossRef
Zurück zum Zitat Whiteley W, Chong WL, Sengupta A, Sandercock P (2009) Blood markers for the prognosis of ischemic stroke: a systematic review. Stroke 40:e380–e389PubMedCrossRef Whiteley W, Chong WL, Sengupta A, Sandercock P (2009) Blood markers for the prognosis of ischemic stroke: a systematic review. Stroke 40:e380–e389PubMedCrossRef
Zurück zum Zitat Woodward M, Lowe GD, Campbell DJ, Colman S, Rumley A, Chalmers J, Neal BC, Patel A, Jenkins AJ, Kemp BE, MacMahon SW (2005) Associations of inflammatory and hemostatic variables with the risk of recurrent stroke. Stroke 36:2143–2147PubMedCrossRef Woodward M, Lowe GD, Campbell DJ, Colman S, Rumley A, Chalmers J, Neal BC, Patel A, Jenkins AJ, Kemp BE, MacMahon SW (2005) Associations of inflammatory and hemostatic variables with the risk of recurrent stroke. Stroke 36:2143–2147PubMedCrossRef
Zurück zum Zitat Wu L, Shen Y, Liu X, Ma X, Xi B, Mi J, Lindpaintner K, Tan X, Wang X (2009) The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population. Stroke 40:2973–2976PubMedCrossRef Wu L, Shen Y, Liu X, Ma X, Xi B, Mi J, Lindpaintner K, Tan X, Wang X (2009) The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population. Stroke 40:2973–2976PubMedCrossRef
Metadaten
Titel
A preliminary method development study to identify potential stroke biomarkers in plasma using multiple chromatographies with nanoLC-ESIMS detection
verfasst von
Phanichand Kodali
Julio A. Landero-Figueroa
Joseph Caruso
Opeolu Adeoye
Publikationsdatum
01.10.2013
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 10/2013
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-013-1018-9

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