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Erschienen in: Skeletal Radiology 5/2016

01.05.2016 | Scientific Article

MR-guided perineural injection of the ganglion impar: technical considerations and feasibility

verfasst von: David R. Marker, Paweena U-Thainual, Tamas Ungi, Aaron J. Flammang, Gabor Fichtinger, Iulian I. Iordachita, John A. Carrino, Jan Fritz

Erschienen in: Skeletal Radiology | Ausgabe 5/2016

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Abstract

Objective

Perineural ganglion impar injections are used in the management of pelvic pain syndromes; however, there is no consensus regarding the optimal image guidance. Magnetic resonance imaging (MRI) provides high soft tissue contrast and the potential to directly visualize and target the ganglion. The purpose of this study was to assess the feasibility of MR-guided percutaneous perineural ganglion impar injections.

Materials and methods

Six MR-guided ganglion impar injections were performed in six human cadavers. Procedures were performed with a clinical 1.5-Tesla MRI system through a far lateral transgluteus approach. Ganglion impar visibility, distance from the sacrococcygeal joint, number of intermittent MRI control steps required to place the needle, target error between the intended and final needle tip location, inadvertent punctures of non-targeted vulnerable structures, injectant distribution, and procedure time were determined.

Results

The ganglion impar was seen on MRI in 4/6 (66 %) of cases and located 0.8 mm cephalad to 16.3 mm caudad (average 1.2 mm caudad) to the midpoint of the sacrococcygeal joint. Needle placement required an average of three MRI control steps (range, 2–6). The average target error was 2.2 ± 2.1 mm. In 6/6 cases (100 %), there was appropriate periganglionic distribution and filling of the presacrococcygeal space. No punctures of non-targeted structures occurred. The median procedure time was 20 min (range, 12–29 min).

Conclusion

Interventional MRI can visualize and directly target the ganglion impar for accurate needle placement and successful periganglionic injection with the additional benefit of no ionizing radiation exposure to patient and staff. Our results support clinical evaluation.
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Literatur
1.
Zurück zum Zitat Ahangari A. Prevalence of chronic pelvic pain among women: an updated review. Pain Physician. 2014;17:E141–7.PubMed Ahangari A. Prevalence of chronic pelvic pain among women: an updated review. Pain Physician. 2014;17:E141–7.PubMed
2.
Zurück zum Zitat Mathias SD, Kuppermann M, Liberman RF, Lipschutz RC, Steege JF. Chronic pelvic pain: prevalence, health-related quality of life, and economic correlates. Obstet Gynecol. 1996;87:321–7.CrossRefPubMed Mathias SD, Kuppermann M, Liberman RF, Lipschutz RC, Steege JF. Chronic pelvic pain: prevalence, health-related quality of life, and economic correlates. Obstet Gynecol. 1996;87:321–7.CrossRefPubMed
3.
Zurück zum Zitat Fall M, Baranowski AP, Elneil S, et al. EAU guidelines on chronic pelvic pain. Eur Urol. 2010;57:35–48.CrossRefPubMed Fall M, Baranowski AP, Elneil S, et al. EAU guidelines on chronic pelvic pain. Eur Urol. 2010;57:35–48.CrossRefPubMed
4.
Zurück zum Zitat Green IC, Cohen SL, Finkenzeller D, Christo PJ. Interventional therapies for controlling pelvic pain: what is the evidence? Curr Pain Headache Rep. 2010;14:22–32.CrossRefPubMed Green IC, Cohen SL, Finkenzeller D, Christo PJ. Interventional therapies for controlling pelvic pain: what is the evidence? Curr Pain Headache Rep. 2010;14:22–32.CrossRefPubMed
5.
Zurück zum Zitat Malec-Milewska M, Horosz B, Koleda I, et al. Neurolytic block of ganglion of Walther for the management of chronic pelvic pain. Wideochirurgia i Inne Techniki Malo Inwazyjne [Videosurgery and other miniinvasive techniques]/Kwartalnik pod Patronatem Sekcji Wideochirurgii TChP Oraz Sekcji Chirurgii Bariatrycznej TChP. 2014;9:458–62. Malec-Milewska M, Horosz B, Koleda I, et al. Neurolytic block of ganglion of Walther for the management of chronic pelvic pain. Wideochirurgia i Inne Techniki Malo Inwazyjne [Videosurgery and other miniinvasive techniques]/Kwartalnik pod Patronatem Sekcji Wideochirurgii TChP Oraz Sekcji Chirurgii Bariatrycznej TChP. 2014;9:458–62.
6.
Zurück zum Zitat Scott-Warren JT, Hill V, Rajasekaran A. Ganglion impar blockade: a review. Curr Pain Headache Rep. 2013;17:306.CrossRefPubMed Scott-Warren JT, Hill V, Rajasekaran A. Ganglion impar blockade: a review. Curr Pain Headache Rep. 2013;17:306.CrossRefPubMed
7.
Zurück zum Zitat Walters A, Muhleman M, Osiro S, et al. One is the loneliest number: a review of the ganglion impar and its relation to pelvic pain syndromes. Clin Anat New York NY. 2013;26:855–61. Walters A, Muhleman M, Osiro S, et al. One is the loneliest number: a review of the ganglion impar and its relation to pelvic pain syndromes. Clin Anat New York NY. 2013;26:855–61.
8.
Zurück zum Zitat Restrepo-Garces CE, Saldarriaga NE, Jaramillo S, Gomez CM, Vargas JF, Ramirez LJ. Ganglion impar phenol injection in a pediatric patient with refractory cancer pain. Pain Med. 2014;15:334–6.CrossRefPubMed Restrepo-Garces CE, Saldarriaga NE, Jaramillo S, Gomez CM, Vargas JF, Ramirez LJ. Ganglion impar phenol injection in a pediatric patient with refractory cancer pain. Pain Med. 2014;15:334–6.CrossRefPubMed
9.
Zurück zum Zitat Johnston PJ, Michalek P. Blockade of the ganglion impar (Walther), using ultrasound and a loss of resistance technique. Prague Med Rep. 2012;113:53–7.CrossRefPubMed Johnston PJ, Michalek P. Blockade of the ganglion impar (Walther), using ultrasound and a loss of resistance technique. Prague Med Rep. 2012;113:53–7.CrossRefPubMed
10.
Zurück zum Zitat Lin CS, Cheng JK, Hsu YW, et al. Ultrasound-guided ganglion impar block: a technical report. Pain Med. 2010;11:390–4.CrossRefPubMed Lin CS, Cheng JK, Hsu YW, et al. Ultrasound-guided ganglion impar block: a technical report. Pain Med. 2010;11:390–4.CrossRefPubMed
11.
Zurück zum Zitat Ho KY, Nagi PA, Gray L, Huh BK. An alternative approach to ganglion impar neurolysis under computed tomography guidance for recurrent vulva cancer. Anesthesiology. 2006;105:861–2.CrossRefPubMed Ho KY, Nagi PA, Gray L, Huh BK. An alternative approach to ganglion impar neurolysis under computed tomography guidance for recurrent vulva cancer. Anesthesiology. 2006;105:861–2.CrossRefPubMed
12.
Zurück zum Zitat Plancarte RAC, Patt RB. Presacral blockade of the ganglion of Walther (ganglion impar). Anesthesiology. 1990;73:A751. Plancarte RAC, Patt RB. Presacral blockade of the ganglion of Walther (ganglion impar). Anesthesiology. 1990;73:A751.
13.
Zurück zum Zitat Hong JH, Jang HS. Block of the ganglion impar using a coccygeal joint approach. Reg Anesth Pain Med. 2006;31:583–4.CrossRefPubMed Hong JH, Jang HS. Block of the ganglion impar using a coccygeal joint approach. Reg Anesth Pain Med. 2006;31:583–4.CrossRefPubMed
14.
15.
Zurück zum Zitat Hol PK, Kvarstein G, Viken O, Smedby O, Tonnessen TI. MRI-guided celiac plexus block. J Magn Reson Imaging. 2000;12:562–4.CrossRefPubMed Hol PK, Kvarstein G, Viken O, Smedby O, Tonnessen TI. MRI-guided celiac plexus block. J Magn Reson Imaging. 2000;12:562–4.CrossRefPubMed
16.
Zurück zum Zitat Konig CW, Schott UG, Pereira PL, et al. MR-guided lumbar sympathicolysis. Eur Radiol. 2002;12:1388–93.CrossRefPubMed Konig CW, Schott UG, Pereira PL, et al. MR-guided lumbar sympathicolysis. Eur Radiol. 2002;12:1388–93.CrossRefPubMed
17.
Zurück zum Zitat Fritz J, Chhabra A, Wang KC, Carrino JA. Magnetic resonance neurography-guided nerve blocks for the diagnosis and treatment of chronic pelvic pain syndrome. Neuroimaging Clin N Am. 2014;24:211–34.CrossRefPubMed Fritz J, Chhabra A, Wang KC, Carrino JA. Magnetic resonance neurography-guided nerve blocks for the diagnosis and treatment of chronic pelvic pain syndrome. Neuroimaging Clin N Am. 2014;24:211–34.CrossRefPubMed
18.
Zurück zum Zitat Fritz J, Bizzell C, Kathuria S, et al. High-resolution magnetic resonance-guided posterior femoral cutaneous nerve blocks. Skelet Radiol. 2013;42:579–86.CrossRef Fritz J, Bizzell C, Kathuria S, et al. High-resolution magnetic resonance-guided posterior femoral cutaneous nerve blocks. Skelet Radiol. 2013;42:579–86.CrossRef
19.
Zurück zum Zitat Fritz J, UT P, Ungi T, et al. Augmented reality visualization with image overlay for MRI-guided intervention: accuracy for lumbar spinal procedures with a 1.5-T MRI system. AJR. 2012;198:W266–73.CrossRefPubMed Fritz J, UT P, Ungi T, et al. Augmented reality visualization with image overlay for MRI-guided intervention: accuracy for lumbar spinal procedures with a 1.5-T MRI system. AJR. 2012;198:W266–73.CrossRefPubMed
20.
Zurück zum Zitat Fritz J, UT P, Ungi T, et al. Augmented reality visualization with use of image overlay technology for MR imaging-guided interventions: assessment of performance in cadaveric shoulder and hip arthrography at 1.5 T. Radiology. 2012;265:254–9.CrossRefPubMedPubMedCentral Fritz J, UT P, Ungi T, et al. Augmented reality visualization with use of image overlay technology for MR imaging-guided interventions: assessment of performance in cadaveric shoulder and hip arthrography at 1.5 T. Radiology. 2012;265:254–9.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Agarwal-Kozlowski K, Lorke DE, Habermann CR, Am Esch JS, Beck H. CT-guided blocks and neuroablation of the ganglion impar (Walther) in perineal pain: anatomy, technique, safety, and efficacy. Clin J Pain. 2009;25:570–6.CrossRefPubMed Agarwal-Kozlowski K, Lorke DE, Habermann CR, Am Esch JS, Beck H. CT-guided blocks and neuroablation of the ganglion impar (Walther) in perineal pain: anatomy, technique, safety, and efficacy. Clin J Pain. 2009;25:570–6.CrossRefPubMed
22.
Zurück zum Zitat Fritz J, Thomas C, Clasen S, Claussen CD, Lewin JS, Pereira PL. Freehand real-time MRI-guided lumbar spinal injection procedures at 1.5 T: feasibility, accuracy, and safety. AJR. 2009;192:W161–7.CrossRefPubMed Fritz J, Thomas C, Clasen S, Claussen CD, Lewin JS, Pereira PL. Freehand real-time MRI-guided lumbar spinal injection procedures at 1.5 T: feasibility, accuracy, and safety. AJR. 2009;192:W161–7.CrossRefPubMed
23.
Zurück zum Zitat Oh CS, Chung IH, Ji HJ, Yoon DM. Clinical implications of topographic anatomy on the ganglion impar. Anesthesiology. 2004;101:249–50.CrossRefPubMed Oh CS, Chung IH, Ji HJ, Yoon DM. Clinical implications of topographic anatomy on the ganglion impar. Anesthesiology. 2004;101:249–50.CrossRefPubMed
24.
Zurück zum Zitat Reig E, Abejon D, del Pozo C, Insausti J, Contreras R. Thermocoagulation of the ganglion impar or ganglion of Walther: description of a modified approach—preliminary results in chronic, nononcological pain. Pain Pract. 2005;5:103–10.CrossRefPubMed Reig E, Abejon D, del Pozo C, Insausti J, Contreras R. Thermocoagulation of the ganglion impar or ganglion of Walther: description of a modified approach—preliminary results in chronic, nononcological pain. Pain Pract. 2005;5:103–10.CrossRefPubMed
25.
Zurück zum Zitat Fritz J, UT P, Ungi T, et al. Augmented reality visualisation using an image overlay system for MR-guided interventions: technical performance of spine injection procedures in human cadavers at 1.5 Tesla. Eur Radiol. 2013;23:235–45.CrossRefPubMed Fritz J, UT P, Ungi T, et al. Augmented reality visualisation using an image overlay system for MR-guided interventions: technical performance of spine injection procedures in human cadavers at 1.5 Tesla. Eur Radiol. 2013;23:235–45.CrossRefPubMed
26.
Zurück zum Zitat Weiss CR, Marker DR, Fischer GS, Fichtinger G, Machado AJ, Carrino JA. Augmented reality visualization using image-overlay for MR-guided interventions: system description, feasibility, and initial evaluation in a spine phantom. AJR. 2011;196:W305–7.CrossRefPubMed Weiss CR, Marker DR, Fischer GS, Fichtinger G, Machado AJ, Carrino JA. Augmented reality visualization using image-overlay for MR-guided interventions: system description, feasibility, and initial evaluation in a spine phantom. AJR. 2011;196:W305–7.CrossRefPubMed
27.
Zurück zum Zitat U-Thainual P, Fritz J, Moonjaita C, et al. MR image overlay guidance: system evaluation for preclinical use. Int J Comput Assist Radiol Surg. 2013;8:365–78.CrossRefPubMed U-Thainual P, Fritz J, Moonjaita C, et al. MR image overlay guidance: system evaluation for preclinical use. Int J Comput Assist Radiol Surg. 2013;8:365–78.CrossRefPubMed
28.
Zurück zum Zitat Gautam SK, Agarwal A, Das PK. Ganglion impar block for sympathetically mediated pain in a patient with a rectourethral fistula. Pain Physician. 2014;17:E107.PubMed Gautam SK, Agarwal A, Das PK. Ganglion impar block for sympathetically mediated pain in a patient with a rectourethral fistula. Pain Physician. 2014;17:E107.PubMed
29.
Zurück zum Zitat Gopal H, Mc Crory C. Coccygodynia treated by pulsed radio frequency treatment to the Ganglion of Impar: a case series. J Back Musculoskelet Rehabil. 2014;27:349–54.PubMed Gopal H, Mc Crory C. Coccygodynia treated by pulsed radio frequency treatment to the Ganglion of Impar: a case series. J Back Musculoskelet Rehabil. 2014;27:349–54.PubMed
30.
Zurück zum Zitat Gurses E. Impar ganglion radiofrequency application in successful management of oncologic perineal pain. JPMA. 2014;64:697–9. Gurses E. Impar ganglion radiofrequency application in successful management of oncologic perineal pain. JPMA. 2014;64:697–9.
31.
Zurück zum Zitat Khosla A, Adeyefa O, Nasir S. Successful treatment of radiation-induced proctitis pain by blockade of the ganglion impar in an elderly patient with prostate cancer: a case report. Pain Med. 2013;14:662–6.CrossRefPubMed Khosla A, Adeyefa O, Nasir S. Successful treatment of radiation-induced proctitis pain by blockade of the ganglion impar in an elderly patient with prostate cancer: a case report. Pain Med. 2013;14:662–6.CrossRefPubMed
32.
Zurück zum Zitat Bhatnagar S, Khanna S, Roshni S, et al. Early ultrasound-guided neurolysis for pain management in gastrointestinal and pelvic malignancies: an observational study in a tertiary care center of urban India. Pain Pract. 2012;12:23–32.CrossRefPubMed Bhatnagar S, Khanna S, Roshni S, et al. Early ultrasound-guided neurolysis for pain management in gastrointestinal and pelvic malignancies: an observational study in a tertiary care center of urban India. Pain Pract. 2012;12:23–32.CrossRefPubMed
33.
Zurück zum Zitat Usta B, Gozdemir M, Sert H, Muslu B, Demircioglu RI. Fluoroscopically guided ganglion impar block by pulsed radiofrequency for relieving coccydynia. J Pain Symptom Manag. 2010;39:e1–2.CrossRef Usta B, Gozdemir M, Sert H, Muslu B, Demircioglu RI. Fluoroscopically guided ganglion impar block by pulsed radiofrequency for relieving coccydynia. J Pain Symptom Manag. 2010;39:e1–2.CrossRef
34.
Zurück zum Zitat Lim SJ, Park HJ, Lee SH, Moon DE. Ganglion impar block with botulinum toxin type A for chronic perineal pain: a case report. Korean J Pain. 2010;23:65–9.CrossRefPubMedPubMedCentral Lim SJ, Park HJ, Lee SH, Moon DE. Ganglion impar block with botulinum toxin type A for chronic perineal pain: a case report. Korean J Pain. 2010;23:65–9.CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Demircay E, Kabatas S, Cansever T, Yilmaz C, Tuncay C, Altinors N. Radiofrequency thermocoagulation of ganglion impar in the management of coccydynia: preliminary results. Turk Neurosurg. 2010;20:328–33.PubMed Demircay E, Kabatas S, Cansever T, Yilmaz C, Tuncay C, Altinors N. Radiofrequency thermocoagulation of ganglion impar in the management of coccydynia: preliminary results. Turk Neurosurg. 2010;20:328–33.PubMed
36.
Zurück zum Zitat Foye PM, Patel SI. Paracoccygeal corkscrew approach to ganglion impar injections for tailbone pain. Pain Pract. 2009;9:317–21.CrossRefPubMed Foye PM, Patel SI. Paracoccygeal corkscrew approach to ganglion impar injections for tailbone pain. Pain Pract. 2009;9:317–21.CrossRefPubMed
37.
Zurück zum Zitat Ellinas H, Sethna NF. Ganglion impar block for management of chronic coccydynia in an adolescent. Paediatr Anaesth. 2009;19:1137–8.CrossRefPubMed Ellinas H, Sethna NF. Ganglion impar block for management of chronic coccydynia in an adolescent. Paediatr Anaesth. 2009;19:1137–8.CrossRefPubMed
38.
Zurück zum Zitat Datir A, Connell D. CT-guided injection for ganglion impar blockade: a radiological approach to the management of coccydynia. Clin Radiol. 2010;65:21–5.CrossRefPubMed Datir A, Connell D. CT-guided injection for ganglion impar blockade: a radiological approach to the management of coccydynia. Clin Radiol. 2010;65:21–5.CrossRefPubMed
39.
Zurück zum Zitat Toshniwal GR, Dureja GP, Prashanth SM. Transsacrococcygeal approach to ganglion impar block for management of chronic perineal pain: a prospective observational study. Pain Physician. 2007;10:661–6.PubMed Toshniwal GR, Dureja GP, Prashanth SM. Transsacrococcygeal approach to ganglion impar block for management of chronic perineal pain: a prospective observational study. Pain Physician. 2007;10:661–6.PubMed
40.
Zurück zum Zitat Loev MA, Varklet VL, Wilsey BL, Ferrante FM. Cryoablation: a novel approach to neurolysis of the ganglion impar. Anesthesiology. 1998;88:1391–3.CrossRefPubMed Loev MA, Varklet VL, Wilsey BL, Ferrante FM. Cryoablation: a novel approach to neurolysis of the ganglion impar. Anesthesiology. 1998;88:1391–3.CrossRefPubMed
41.
Zurück zum Zitat Nebab EG, Florence IM. An alternative needle geometry for interruption of the ganglion impar. Anesthesiology. 1997;86:1213–4.CrossRefPubMed Nebab EG, Florence IM. An alternative needle geometry for interruption of the ganglion impar. Anesthesiology. 1997;86:1213–4.CrossRefPubMed
42.
Zurück zum Zitat Eggleston ST, Lush LW. Understanding allergic reactions to local anesthetics. Ann Pharmacother. 1996;30:851–7.PubMed Eggleston ST, Lush LW. Understanding allergic reactions to local anesthetics. Ann Pharmacother. 1996;30:851–7.PubMed
Metadaten
Titel
MR-guided perineural injection of the ganglion impar: technical considerations and feasibility
verfasst von
David R. Marker
Paweena U-Thainual
Tamas Ungi
Aaron J. Flammang
Gabor Fichtinger
Iulian I. Iordachita
John A. Carrino
Jan Fritz
Publikationsdatum
01.05.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Skeletal Radiology / Ausgabe 5/2016
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-016-2333-7

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