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01.09.2008 | Vascular-Interventional

MR imaging of thrombi using EP-2104R, a fibrin-specific contrast agent: initial results in patients

verfasst von: Elmar Spuentrup, Rene M. Botnar, Andrea J. Wiethoff, Tareq Ibrahim, Sebastian Kelle, Marcus Katoh, Murat Özgun, Eike Nagel, Josef Vymazal, Phil B. Graham, Rolf W. Günther, David Maintz

Erschienen in: European Radiology | Ausgabe 9/2008

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Abstract

This study was an initial phase II trial in humans of molecular magnetic resonance (MR) imaging for improved visualization of thrombi in vessel territories potentially responsible for stroke using a new fibrin-specific contrast agent (EP-2104R). Eleven patients with thrombus in the left ventricle (n = 2), left or right atrium (n = 4), thoracic aorta (n = 4) or carotid artery (n = 1) as verified by an index examination (ultrasound, computed tomograpy, or conventional MR) were enrolled. All MR imaging was performed on 1.5 T whole-body MR-system using an inversion-recovery black-blood gradient-echo sequence. The same sequence was performed before and 2–6 h after low-dose intravenous administration of 4 μmol/kg EP-2104R. Two investigators assessed image quality and signal amplification. Furthermore, contrast-to-noise ratios (CNR) between the clot and the blood pool/surrounding soft tissue before and after administration of the contrast agent were compared using Student’s t-test. MR imaging and data analysis were successfully completed in 10 patients. No major adverse effects occurred. On enhanced images, thrombi demonstrated high signal amplification, typically at the clot surface, with a significantly increased contrast in comparison to the surrounding blood pool and soft tissue (CNR for clot vs. blood pool, unenhanced and enhanced: 6 ± 8 and 29 ± 14; CNR for clot vs. soft tissue, unenhanced and enhanced: 0 ± 4 and 21 ± 13; P < 0.01 for both comparisons). EP-2104R allows for molecular MR imaging of thrombi potentially responsible for stroke. High contrast between thrombus and surrounding blood and soft tissues can be achieved with enhanced imaging.

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Titel: MR imaging of thrombi using EP-2104R, a fibrin-specific contrast agent: initial results in patients
verfasst von: Elmar Spuentrup
Rene M. Botnar
Andrea J. Wiethoff
Tareq Ibrahim
Sebastian Kelle
Marcus Katoh
Murat Özgun
Eike Nagel
Josef Vymazal
Phil B. Graham
Rolf W. Günther
David Maintz
Publikationsdatum: 01.09.2008
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 9/2008
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-008-0965-2

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MR imaging of thrombi using EP-2104R, a fibrin-specific contrast agent: initial results in patients

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