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01.08.2012 | Experimental

MR T1ρ as an imaging biomarker for monitoring liver injury progression and regression: an experimental study in rats with carbon tetrachloride intoxication

verfasst von: Feng Zhao, Yi-Xiang J Wang, Jing Yuan, Min Deng, Hing Lok Wong, Eagle S. H. Chu, Minnie Y. Y. Go, Gao-Jun Teng, Anil T. Ahuja, Jun Yu

Erschienen in: European Radiology | Ausgabe 8/2012

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Abstract

Objectives

Recently it was shown that the magnetic resonance imaging (MRI) T1ρ value increased with the severity of liver fibrosis in rats with bile duct ligation. Using a rat carbon tetrachloride (CCl₄) liver injury model, this study further investigated the merit of T1ρ relaxation for liver fibrosis evaluation.

Methods

Male Sprague-Dawley rats received intraperitoneal injection of 2 ml/kg CCl₄ twice weekly for up to 6 weeks. Then CCl₄ was withdrawn and the animals were allowed to recover. Liver T1ρ MRI and conventional T2-weighted images were acquired. Animals underwent MRI at baseline and at 2 days, 2 weeks, 4 weeks and 6 weeks post CCl₄ injection, and they were also examined at 1 week and 4 weeks post CCl₄ withdrawal. Liver histology was also sampled at these time points.

Results

Liver T1ρ values increased slightly, though significantly, on day 2, and then increased further and were highest at week 6 post CCl₄ insults. The relative liver signal intensity change on T2-weighted images followed a different time course compared with that of T1ρ. Liver T1ρ values decreased upon the withdrawal of the CCl₄ insult. Histology confirmed the animals had typical CCl₄ liver injury and fibrosis progression and regression processes.

Conclusions

MR T1ρ imaging can monitor CCl₄-induced liver injury and fibrosis.

Key Points

• MR T1ρ is a valuable imaging biomarker for liver injury/fibrosis.

• Liver T1ρ was only mildly affected by oedema and acute inflammation.

• Liver MR T1ρ decreased when liver fibrosis and injury regressed.

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Titel: MR T1ρ as an imaging biomarker for monitoring liver injury progression and regression: an experimental study in rats with carbon tetrachloride intoxication
verfasst von: Feng Zhao
Yi-Xiang J Wang
Jing Yuan
Min Deng
Hing Lok Wong
Eagle S. H. Chu
Minnie Y. Y. Go
Gao-Jun Teng
Anil T. Ahuja
Jun Yu
Publikationsdatum: 01.08.2012
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 8/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2419-0

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Springer Medizin

MR T1ρ as an imaging biomarker for monitoring liver injury progression and regression: an experimental study in rats with carbon tetrachloride intoxication

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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