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24.03.2017 | Cardiac

Myocardial segmentation based on coronary anatomy using coronary computed tomography angiography: Development and validation in a pig model

verfasst von: Mi Sun Chung, Dong Hyun Yang, Young-Hak Kim, Soo-Jin Kang, Joonho Jung, Namkug Kim, Seung-Ho Heo, Seunghee Baek, Joon Beom Seo, Byoung Wook Choi, Joon-Won Kang, Tae-Hwan Lim

Erschienen in: European Radiology | Ausgabe 10/2017

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Abstract

Objectives

To validate a method for performing myocardial segmentation based on coronary anatomy using coronary CT angiography (CCTA).

Methods

Coronary artery-based myocardial segmentation (CAMS) was developed for use with CCTA. To validate and compare this method with the conventional American Heart Association (AHA) classification, a single coronary occlusion model was prepared and validated using six pigs. The unstained occluded coronary territories of the specimens and corresponding arterial territories from CAMS and AHA segmentations were compared using slice-by-slice matching and 100 virtual myocardial columns.

Results

CAMS more precisely predicted ischaemic area than the AHA method, as indicated by 95% versus 76% (p < 0.001) of the percentage of matched columns (defined as percentage of matched columns of segmentation method divided by number of unstained columns in the specimen). According to the subgroup analyses, CAMS demonstrated a higher percentage of matched columns than the AHA method in the left anterior descending artery (100% vs. 77%; p < 0.001) and mid- (99% vs. 83%; p = 0.046) and apical-level territories of the left ventricle (90% vs. 52%; p = 0.011).

Conclusions

CAMS is a feasible method for identifying the corresponding myocardial territories of the coronary arteries using CCTA.

Key Points

• CAMS is a feasible method for identifying corresponding coronary territory using CTA

• CAMS is more accurate in predicting coronary territory than the AHA method

• The AHA method may underestimate the ischaemic territory of LAD stenosis

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Titel: Myocardial segmentation based on coronary anatomy using coronary computed tomography angiography: Development and validation in a pig model
verfasst von: Mi Sun Chung
Dong Hyun Yang
Young-Hak Kim
Soo-Jin Kang
Joonho Jung
Namkug Kim
Seung-Ho Heo
Seunghee Baek
Joon Beom Seo
Byoung Wook Choi
Joon-Won Kang
Tae-Hwan Lim
Publikationsdatum: 24.03.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 10/2017
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-4793-0

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Myocardial segmentation based on coronary anatomy using coronary computed tomography angiography: Development and validation in a pig model