nach oben

Erschienen in:

22.06.2020 | Musculoskeletal

Natural history of new horizontal meniscal tears in individuals at risk for and with mild to moderate osteoarthritis: data from osteoarthritis initiative

verfasst von: Magdalena Posadzy, Gabby B. Joseph, Charles E. McCulloch, Michael C. Nevitt, John A. Lynch, Nancy E. Lane, Thomas M. Link

Erschienen in: European Radiology | Ausgabe 11/2020

Einloggen, um Zugang zu erhalten

Abstract

Objectives

To study the natural history of new horizontal meniscal tears and their association with progression of cartilage degeneration in individuals at risk for or with mild to moderate knee osteoarthritis over 4 years.

Methods

Individuals who developed a new meniscal tear in the right knee over 2 years were selected from the Osteoarthritis Initiative 3T MRI studies. Knee structural changes were analyzed at the time of tear appearance (baseline), and after 4 years using a modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). Meniscal tears were classified as either horizontal tears or non-horizontal tears. Individuals without a meniscal tear were 1:3 frequency matched according to BMI, gender, race, and age and served as the control group. Linear regression analysis was used to compare cross-sectional and longitudinal changes in cartilage WORMS scores.

Results

Forty-one subjects developed horizontal tears, including one indiviudal who developed a tear in both menisci, and 34 developed non-horizonal tears. We found that (29/41 (70.7%)) of horizontal and (20/34 (58.8%)) of non-horizonatal tears were stable during follow-up (p = 0.281). Although knees with an incident tear had higher than controls WORMS MAX total knee scores at baseline (coef. = 0.47, p = 0.044, 95% CI = 0.01 to 0.93), there were no significant differences between the horizontal subgroup and knees without tears in overall cartilage scores at baseline and in progression over 4 years of follow-up.

Conclusions

New horizontal meniscal tears tended to be stable over 4 years and presented no significant differences in progression of cartilage degeneration when compared with knees without tears.

Key Points

• Most of horizonal meniscal tears were stable over 4 years.

• There were no statistically significant differences in overall progression of cartilage degenerative changes between knees with horizonal meniscal tears and control knees without tears

• Horizontal tears most often occurred at the posterior horn of the medial meniscus and at the body of the lateral meniscus.

Nur mit Berechtigung zugänglich

Wallace IJ, Worthington S, Felson DT et al (2017) Knee osteoarthritis has doubled in prevalence since the mid-20th century. Proc Natl Acad Sci U S A 114:9332–9336PubMedPubMedCentral

Murray CJ, Vos T, Lozano R et al (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2197–2223PubMed

Lohmander LS, Englund PM, Dahl LL, Roos EM (2007) The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med 35:1756–1769PubMed

Kumar D, Schooler J, Zuo J et al (2013) Trabecular bone structure and spatial differences in articular cartilage MR relaxation times in individuals with posterior horn medial meniscal tears. Osteoarthritis Cartilage 21:86–93PubMed

Lo GH, Hunter DJ, Nevitt M, Lynch J, McAlindon TE, OAI Investigators Group (2009) Strong association of MRI meniscal derangement and bone marrow lesions in knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis Cartilage 17:743–747

Henry S, Mascarenhas R, Kowalchuk D, Forsythe B, Irrgang JJ, Harner CD (2012) Medial meniscus tear morphology and chondral degeneration of the knee: is there a relationship? Arthroscopy 28:1124–1134 e1122PubMed

Kan A, Oshida M, Oshida S, Imada M, Nakagawa T, Okinaga S (2010) Anatomical significance of a posterior horn of medial meniscus: the relationship between its radial tear and cartilage degradation of joint surface. Sports Med Arthrosc Rehabil Ther Technol 2:1PubMedPubMedCentral

von Porat A, Roos EM, Roos H (2004) High prevalence of osteoarthritis 14 years after an anterior cruciate ligament tear in male soccer players: a study of radiographic and patient relevant outcomes. Ann Rheum Dis 63:269–273

Foreman SC, Neumann J, Joseph GB et al (2019) Longitudinal MRI structural findings observed in accelerated knee osteoarthritis: data from the Osteoarthritis Initiative. Skeletal Radiol 48:1949–1959PubMed

10.

Neumann J, Kern K, Sun D et al (2019) Cartilage degeneration post-meniscectomy performed for degenerative disease versus trauma: data from the Osteoarthritis Initiative. Skeletal Radiol 49:231–240PubMed

11.

Harkey MS, Davis JE, Lu B et al (2019) Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis. BMC Musculoskelet Disord 20:241PubMedPubMedCentral

12.

Driban JB, Davis JE, Lu B et al (2019) Accelerated knee osteoarthritis is characterized by destabilizing meniscal tears and preradiographic structural disease burden. Arthritis Rheumatol 71:1089–1100PubMedPubMedCentral

13.

Englund M, Guermazi A, Gale D et al (2008) Incidental meniscal findings on knee MRI in middle-aged and elderly persons. N Engl J Med 359:1108–1115PubMedPubMedCentral

14.

Kumm J, Roemer FW, Guermazi A, Turkiewicz A, Englund M (2016) Natural history of intrameniscal signal intensity on knee MR images: six years of data from the Osteoarthritis Initiative. Radiology 278:164–171PubMed

15.

Krych AJ, Reardon PJ, Johnson NR et al (2017) Non-operative management of medial meniscus posterior horn root tears is associated with worsening arthritis and poor clinical outcome at 5-year follow-up. Knee Surg Sports Traumatol Arthrosc 25:383–389PubMed

16.

Englund M, Guermazi A, Roemer FW et al (2009) Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: the Multicenter Osteoarthritis Study. Arthritis Rheum 60:831–839PubMedPubMedCentral

17.

Metcalf MH, Barrett GR (2004) Prospective evaluation of 1485 meniscal tear patterns in patients with stable knees. Am J Sports Med 32:675–680PubMed

18.

Smillie IS (1968) The current pattern of the pathology of meniscus tears. Proc R Soc Med 61:44–45PubMedPubMedCentral

19.

Pauli C, Grogan SP, Patil S et al (2011) Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis. Osteoarthritis Cartilage 19:1132–1141PubMedPubMedCentral

20.

Mesiha M, Zurakowski D, Soriano J, Nielson JH, Zarins B, Murray MM (2007) Pathologic characteristics of the torn human meniscus. Am J Sports Med 35:103–112PubMed

21.

Christoforakis J, Pradhan R, Sanchez-Ballester J, Hunt N, Strachan RK (2005) Is there an association between articular cartilage changes and degenerative meniscus tears? Arthroscopy 21:1366–1369PubMed

22.

Beaufils P, Becker R, Kopf S et al (2017) Surgical management of degenerative meniscus lesions: the 2016 ESSKA Meniscus Consensus. Joints 5:59–69PubMedPubMedCentral

23.

Lewandrowski KU, Muller J, Schollmeier G (1997) Concomitant meniscal and articular cartilage lesions in the femorotibial joint. Am J Sports Med 25:486–494PubMed

24.

Peterfy CG, Schneider E, Nevitt M (2008) The osteoarthritis initiative: report on the design rationale for the magnetic resonance imaging protocol for the knee. Osteoarthritis Cartilage 16:1433–1441PubMedPubMedCentral

25.

Peterfy CG, Guermazi A, Zaim S et al (2004) Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage 12:177–190PubMed

26.

Alizai H, Virayavanich W, Joseph GB et al (2014) Cartilage lesion score: comparison of a quantitative assessment score with established semiquantitative MR scoring systems. Radiology 271:479–487PubMedPubMedCentral

27.

Stehling C, Lane NE, Nevitt MC, Lynch J, McCulloch CE, Link TM (2010) Subjects with higher physical activity levels have more severe focal knee lesions diagnosed with 3T MRI: analysis of a non-symptomatic cohort of the osteoarthritis initiative. Osteoarthritis Cartilage 18:776–786PubMedPubMedCentral

28.

Gersing AS, Schwaiger BJ, Heilmeier U et al (2017) Evaluation of chondrocalcinosis and associated knee joint degeneration using MR imaging: data from the Osteoarthritis Initiative. Eur Radiol 27:2497–2506PubMed

29.

Neumann J, Guimaraes JB, Heilmeier U et al (2019) Diabetics show accelerated progression of knee cartilage and meniscal lesions: data from the osteoarthritis initiative. Skeletal Radiol 48:919–930PubMed

30.

Bucknor MD, Nardo L, Joseph GB et al (2015) Association of cartilage degeneration with four year weight gain--3T MRI data from the Osteoarthritis Initiative. Osteoarthritis Cartilage 23:525–531PubMedPubMedCentral

31.

Makris EA, Hadidi P, Athanasiou KA (2011) The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration. Biomaterials 32:7411–7431PubMedPubMedCentral

32.

Ozdemir M, Kavak RP (2019) Meniscal lesions in geriatric population: prevalence and association with knee osteoarthritis. Curr Aging Sci 12:67–73PubMedPubMedCentral

33.

Jackson T, Fabricant PD, Beck N, Storey E, Patel NM, Ganley TJ (2019) Epidemiology, injury patterns, and treatment of meniscal tears in pediatric patients: a 16-year experience of a single center. Orthop J Sports Med 7:2325967119890325PubMedPubMedCentral

34.

Terzidis IP, Christodoulou A, Ploumis A, Givissis P, Natsis K, Koimtzis M (2006) Meniscal tear characteristics in young athletes with a stable knee: arthroscopic evaluation. Am J Sports Med 34:1170–1175PubMed

35.

Mansori AE, Lording T, Schneider A, Dumas R, Servien E, Lustig S (2018) Incidence and patterns of meniscal tears accompanying the anterior cruciate ligament injury: possible local and generalized risk factors. Int Orthop 42:2113–2121PubMed

36.

Zarins ZA, Bolbos RI, Pialat JB et al (2010) Cartilage and meniscus assessment using T1rho and T2 measurements in healthy subjects and patients with osteoarthritis. Osteoarthritis Cartilage 18:1408–1416PubMedPubMedCentral

37.

Englund M, Roos EM, Lohmander LS (2003) Impact of type of meniscal tear on radiographic and symptomatic knee osteoarthritis: a sixteen-year followup of meniscectomy with matched controls. Arthritis Rheum 48:2178–2187PubMed

38.

Brown MJ, Farrell JP, Kluczynski MA, Marzo JM (2016) Biomechanical effects of a horizontal medial meniscal tear and subsequent leaflet resection. Am J Sports Med 44:850–854PubMed

39.

Koh JL, Yi SJ, Ren Y, Zimmerman TA, Zhang LQ (2016) Tibiofemoral contact mechanics with horizontal cleavage tear and resection of the medial meniscus in the human knee. J Bone Joint Surg Am 98:1829–1836PubMed

40.

Cho WJ, Kim JM, Lee BS, Kim HJ, Bin SI (2019) Discoid lateral meniscus: a simple horizontal tear was associated with less articular cartilage degeneration compared to other types of tear. Knee Surg Sports Traumatol Arthrosc 27:3390–3395

41.

Roemer FW, Kwoh CK, Hannon MJ et al (2015) What comes first? Multitissue involvement leading to radiographic osteoarthritis: magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative. Arthritis Rheumatol 67:2085–2096PubMedPubMedCentral

42.

Jarraya M, Roemer FW, Englund M et al (2017) Meniscus morphology: does tear type matter? A narrative review with focus on relevance for osteoarthritis research. Semin Arthritis Rheum 46:552–561PubMed

43.

Longo UG, Ciuffreda M, Candela V et al (2019) Knee osteoarthritis after arthroscopic partial meniscectomy: prevalence and progression of radiographic changes after 5 to 12 years compared with contralateral knee. J Knee Surg 32:407–413PubMed

44.

Fox AJ, Bedi A, Rodeo SA (2012) The basic science of human knee menisci: structure, composition, and function. Sports Health 4:340–351PubMedPubMedCentral

45.

Shanmugaraj A, Tejpal T, Ekhtiari S et al (2019) The repair of horizontal cleavage tears yields higher complication rates compared to meniscectomy: a systematic review. Knee Surg Sports Traumatol Arthrosc 28:915–925PubMed

46.

Thorlund JB, Juhl CB, Roos EM, Lohmander LS (2015) Arthroscopic surgery for degenerative knee: systematic review and meta-analysis of benefits and harms. Br J Sports Med 49:1229–1235PubMedPubMedCentral

47.

van de Graaf V, Bloembergen CM, Willigenburg NWP et al (2019) Can even experienced orthopaedic surgeons predict who will benefit from surgery when patients present with degenerative meniscal tears? A survey of 194 orthopaedic surgeons who made 3880 predictions. Br J Sports Med 54:354–359PubMedPubMedCentral

48.

Bhattacharyya T, Gale D, Dewire P et al (2003) The clinical importance of meniscal tears demonstrated by magnetic resonance imaging in osteoarthritis of the knee. J Bone Joint Surg Am 85:4–9PubMed

49.

Snoeker BA, Bakker EW, Kegel CA, Lucas C (2013) Risk factors for meniscal tears: a systematic review including meta-analysis. J Orthop Sports Phys Ther 43:352–367PubMed

Titel: Natural history of new horizontal meniscal tears in individuals at risk for and with mild to moderate osteoarthritis: data from osteoarthritis initiative
verfasst von: Magdalena Posadzy
Gabby B. Joseph
Charles E. McCulloch
Michael C. Nevitt
John A. Lynch
Nancy E. Lane
Thomas M. Link
Publikationsdatum: 22.06.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 11/2020
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-020-06960-0

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Natural history of new horizontal meniscal tears in individuals at risk for and with mild to moderate osteoarthritis: data from osteoarthritis initiative