Introduction
Method
Epidemiology
Reference | Location | Definition criteria | Population surveyed | NDPH prevalence | Female | Male | F:M ratio | Age of onset | Race |
---|---|---|---|---|---|---|---|---|---|
Castillo et. al 1999 [7] | Spain | S-L | 1883 adult general population | 0.1%GP | |||||
Li 2002 [8] | USA | S-L | 56 NDPH cases | 40(71%) | 16(29%) | 2.5 | 12–78 | Caucasian:87% Black:11% Hispanic:2% | |
Bigal et. al 2004 [9] | USA | S-L | 170 adolescents with CDH 638 adults with CDH | 21% CDH 10.8% CDH | |||||
Takase et. al 2004 [10] | Japan | ICHD2 | 30 NDPH cases of 1760 CDH | 1.7% CDH | 13(43%) | 17(57%) | 0.8 | 13–73 | |
Meineri et. al 2004 [11] | Italy | ICHD2, S-L | 18 NDPH cases of 265 CDH | 6.7% CDH | 11(61%) | 7(39%) | 1.6 | 13–76 | |
Mack 2004 [12] | USA | M-ICHD2 | 175 children with CDH | 23% CDH | 27(67.5%) | 13(32.5%) | 2.1 | ||
Kung et. al 2008 [13] | USA | M-ICHD 2 | 306 children and adolescents in a tertiary headache center | 28% CDH | 34(64.2%) | 19(35.8%) | 1.7 | ||
Grande et. al 2009 [14] | Norway | ICHD 2 | 30,000 adult general population | 0.03% GP | |||||
Robbins 2010 [15] | USA | M-ICHD2 | 71 NDPH | 51(72%) | 20(28%) | 2.5 | 8–76 | Cacausian:80.3% Black:5.6% Hispanic:9.9% | |
Prakash 2012 [16] | India | M-ICHD2 | 63 NDPH | 36(57%) | 27(43%) | 1.3 | 18–68 | ||
Rozen 2016 [17] | USA | ICHD-3β | 97 NDPH | 65(67%) | 32(33%) | 2 | Mea: F:32.4 M:35.8 | Cacausian:98% Black:1% Hispanic:1% | |
Uniyal et. al 2017 [18] | India | ICHD-3β | 55 NDPH | 45.5% | 54.5% | 0.8 | Mea: 28.24 |
Clinical findings
Precipitating factors
Reference | Number of NDPH patients | No Triggering factor | Infection or flu-like illness | Stressful life event | Trauma /surgery | Other |
---|---|---|---|---|---|---|
Li 2002 [8] | 56 | > 33% | 30% | 12% | 12% | |
Mack 2004 [12] | 40 (pediatric NDPH) | 5(12%) | 17(43%) | 13(33%) | 5(12%)idiopathic intracranial hypertension, high altitude climbing | |
Takase 2004 [10] | 30 | 24(80%) |
a
| 6(20%) |
a
| |
Robbins 2010 [15] | 71 | 38(53.5%) | 10(14.1%) | 7(9.9%) | 6(8%)menarche, SSRI withdrawal, HPV vaccination | |
Peng et. al 2011 [19] | 92 | 65(71%) | 3(3%) | 24(26%) | ||
Prakash 2012 [16] | 63 | 29(46%) | 18(29%) | 5(8%) | 10(16%) | 9(14%) postpartum, medication overuse |
Rozen 2016 [17] | 97 Female:65 Male:34 | 51(53%) Female: 52% Male: 53% Mean age:30.4 | 21(22%) Female: 22% Male: 22% Mean age:31.8 | 9(9%) Female: 11% Male: 6% Mean age:28.1 | 9(9%) Female:9% Male:9% Mean age:63.3 | 7(7%) syncope, hormone, toxin and medication, cervical massage |
Uniyal et. al 2017 [18] | 55 | 35(63.5%) | 10(18%) | 5(9.1%) | 5(9.1%) |
Pathogenesis
Diagnosis of NDPH
• Low or raised CSF pressure (Spontaneous CSF leak, Idiopathic intracranial hypertension, Intracranial mass lesion) • Cerebral venous thrombosis • Cranial artery dissection • Cranial arteritis • Posttraumatic headache (subarachnoid hemorrhage, subdural hematoma, …) • Meningitis • Sphenoid sinusitis • Contact-point headache (caused by contact of intranasal structures) |