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Journal of Clinical Immunology

Erschienen in:

01.07.2009

NK and NKT Cells in Aging and Longevity: Role of Zinc and Metallothioneins

verfasst von: Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano, Marco Malavolta

Erschienen in: Journal of Clinical Immunology | Ausgabe 4/2009

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Abstract

Introduction

During aging, dysregulated immune functions occur contributing to increased susceptibility to morbidity and mortality. However, these dysregulations are normally counterbalanced by continuous adaptation of the body to the deteriorative changes occurring over time. These adaptive changes well occur in healthy centenarians.

Discussion

Both innate (natural) and adaptive (acquired) immune responses decline with advancing age. Natural killer (NK) and natural killer T (NKT) cell cytotoxicity, representing one of best models of innate immune response, decreases in aging as well as interferon-γ (IFN-γ) production by both activated types of cells. Both NK and NKT cell cytotoxicity and IFN-γ production increase in very old age with respect to normal aging, especially by NKT cells bearing TCRγδ. The role played by zinc and metallothioneins (MT) is crucial because this affects NK and NKT cell development, maturation, and functions. In particular, some MT polymorphisms are involved in maintaining innate immune response and intracellular zinc ion availability in aging with thus a role of MT genetic background to escape some age-related diseases with subsequent healthy aging and longevity.

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Titel: NK and NKT Cells in Aging and Longevity: Role of Zinc and Metallothioneins
verfasst von: Eugenio Mocchegiani
Robertina Giacconi
Catia Cipriano
Marco Malavolta
Publikationsdatum: 01.07.2009
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 4/2009
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-009-9298-4

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