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European Radiology
Erschienen in: European Radiology 4/2018

15.11.2017 | Chest

Nonsuppressing normal thymus on chemical-shift MR imaging and anterior mediastinal lymphoma: differentiation with diffusion-weighted MR imaging by using the apparent diffusion coefficient

verfasst von: Adriano Massimiliano Priola, Sandro Massimo Priola, Dario Gned, Maria Teresa Giraudo, Andrea Veltri

Erschienen in: European Radiology | Ausgabe 4/2018

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Abstract

Objectives

To prospectively evaluate usefulness of the apparent diffusion coefficient (ADC) in differentiating anterior mediastinal lymphoma from nonsuppressing normal thymus on chemical-shift MR, and to look at the relationship between patient age and ADC.

Methods

Seventy-three young subjects (25 men, 48 women; age range, 9-29 years), who underwent chemical-shift MR and diffusion-weighted MR were divided into a normal thymus group (group A, 40 subjects), and a lymphoma group (group B, 33 patients). For group A, all subjects had normal thymus with no suppression on opposed-phase chemical-shift MR. Two readers measured the signal intensity index (SII) and ADC. Differences in SII and ADC between groups were tested using t-test. ADC was correlated with age using Pearson correlation coefficient.

Results

Mean SII±standard deviation was 2.7±1.8% for group A and 2.2±2.4% for group B, with no significant difference between groups (P=.270). Mean ADC was 2.48±0.38x10-3mm2/s for group A and 1.24±0.23x10-3mm2/s for group B. A significant difference between groups was found (P<.001), with no overlap in range. Lastly, significant correlation was found between age and ADC (r=0.935, P<.001) in group A.

Conclusions

ADC of diffusion-weighted MR is a noninvasive and accurate parameter for differentiating lymphoma from nonsuppressing thymus on chemical-shift MR in young subjects.

Key Points

• SII cannot differentiate mediastinal lymphoma from nonsuppressing normal thymus at visual assessment
• ADC is useful for distinguishing nonsuppressing normal thymus from mediastinal lymphoma
• ADC is more accurate than transverse-diameter and surface-area in this discrimination
• ADC of normal thymus is age dependent and increases with increasing age
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Metadaten
Titel
Nonsuppressing normal thymus on chemical-shift MR imaging and anterior mediastinal lymphoma: differentiation with diffusion-weighted MR imaging by using the apparent diffusion coefficient
verfasst von
Adriano Massimiliano Priola
Sandro Massimo Priola
Dario Gned
Maria Teresa Giraudo
Andrea Veltri
Publikationsdatum
15.11.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 4/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-5142-z

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