Background
Main text
Genome-wide association studies in migraine
The difficult road from associated SNPs to genes and mechanisms
Genomic regiona | Index SNPb | Secondary SNPc | Gene nearest index SNP | Genes overlapping credible SNPs | Genes prioritised with DEPICT | Pathways identified with g:GOSt tool |
---|---|---|---|---|---|---|
1 | rs10218452 |
PRDM16
|
PRDM16
|
PRDM16
| Vascular function; Metal ion homeostasis | |
rs12135062 | ||||||
2 | rs1572668 |
LRRIQ3
| ||||
3 | rs2078371 |
TSPAN2
|
NGF
| |||
rs7544256 | ||||||
4 | rs6693567 |
ADAMTSL4
|
RPRD2
|
ECM1
| Vascular function | |
5 | rs1925950 |
MEF2D
|
MEF2D
| Vascular function | ||
6 | rs138556413 |
CARF
|
CARF
|
NBEAL1
| ||
7 | rs10166942 |
TRPM8
|
TRPM8
| Ion channel activity | ||
rs566529 | ||||||
8 | rs6791480 |
TGFBR2
|
TGFBR2
| Vascular function; Metal ion homeostasis | ||
9 | rs13078967 |
GPR149
|
ARHGEF26
| Vascular function | ||
10 | rs7684253 |
SPINK2
|
REST
| Vascular function; Metal ion homeostasis; Ion channel activity | ||
11 | rs9349379 |
PHACTR1
|
PHACTR1
| Vascular function | ||
12 | rs140002913 |
NOTCH4
| ||||
13 | rs10456100 |
KCNK5
|
KCNK5
| Ion channel activity | ||
14 | rs67338227 |
FHL5
|
FHL5
| Vascular function | ||
rs4839827 | ||||||
15 | rs28455731 |
GJA1
|
GJA1
| Vascular function | ||
16 | rs1268083 |
HEY2
|
HEY2, NCOA7
|
HEY2
| Vascular function | |
17 | rs186166891 |
SUGCT
|
SUGCT
| |||
18 | rs10155855 |
DOCK4
| ||||
19 | rs6478241 |
ASTN2
|
ASTN2
| |||
20 | rs2506142 |
NRP1
|
NRP1
|
NRP1
| Vascular function; Metal ion homeostasis | |
21 | rs10786156 |
PLCE1
|
PLCE1
|
PLCE1
| Vascular function | |
rs75473620 | ||||||
22 | rs12260159 |
HPSE2
|
HPSE2
|
HPSE2
| ||
23 | rs2223089 |
ARMS2
|
PLEKHA1, HTRA1
|
HTRA1
| Vascular function | |
24 | rs4910165 |
MRVI1
|
MRVI1
|
MRVI1
| ||
25 | rs11031122 |
MPPED2
|
MPPED2
| |||
26 | rs10895275 |
YAP1
|
YAP1
|
YAP1
| Vascular function | |
27 | rs561561 |
IGSF9B
|
IGSF9B
| |||
28 | rs1024905 |
FGF6
|
FGF6
| Vascular function | ||
29 | rs11172113 |
LRP1
|
LRP1
|
LRP1
| Vascular function; Metal ion homeostasis | |
rs11172055 | ||||||
30 | rs11624776 |
ITPK1
| ||||
31 | rs77505915 |
CFDP1
|
CFDP1, TMEM170A
| |||
32 | rs4081947 |
ZCCHC14
|
ZCCHC14
| Vascular function; Metal ion homeostasis | ||
33 | rs75213074 |
WSCD1
| ||||
34 | rs17857135 |
RNF213
|
RNF213
| Metal ion homeostasis | ||
35 | rs111404218 |
JAG1
|
JAG1
| Vascular function; Metal ion homeostasis | ||
36 | rs4814864 |
SLC24A3
|
SLC24A3
| Ion channel activity | ||
37 | rs144017103 |
CCM2L
|
CCM2L
|
CCM2L
| Vascular function | |
38 | rs12845494 |
MED14
|