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International Ophthalmology

Erschienen in:

29.01.2018 | Original Paper

Ocular Demodex folliculorum: prevalence and associated symptoms in an Irish population

verfasst von: Orla Murphy, Veronica O’Dwyer, Aoife Lloyd-McKernan

Erschienen in: International Ophthalmology | Ausgabe 2/2019

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Abstract

Purpose

To investigate the prevalence of ocular Demodex folliculorum (DF) in an Irish population. To validate a modified Ocular Surface Disease Index questionnaire and employ it to evaluate the relationship between dry eye symptoms and the presence of DF.

Methods

One hundred and fifty-six subjects were enrolled in an epidemiological cross-sectional prevalence study. Each subject completed a novel questionnaire on ocular symptoms and was assessed for the presence of DF. Data was analysed to assess prevalence and to search for significant links between each symptom and DF.

Results

An overall prevalence of 68% was found. Total mean number of DF found on microscopic examination was 3.83 mites per subject (range 0–25). The presence of symptoms was higher among individuals with DF (P = 0.04). Itch was found to be the symptom most significantly associated with the presence and number of DF (P = 0.025 and P = 0.035, respectively). The questionnaire showed good internal consistency (Cronbach’s alpha; α > 0.7) and good reliability (Intra-class Correlation Co-efficient; ICC > 0.7). The sensitivity and specificity of a positive symptom result using the questionnaire were 70.8% and 46.9%, respectively.

Conclusion

There is a strong association between the prevalence of DF and symptoms, in particular itchy eyes. However, not all patients with DF will be symptomatic. The newly developed questionnaire is a reliable instrument for measuring change in symptoms over a period of time and suitable for observing patient reported outcomes in interventional treatment studies.

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Spickett SG (1961) Studies on Demodex folliculorum Simon (1842). I. Life history. Parasitology 51:181–192CrossRef

Rufli T, Mumcuoglu Y (1981) The hair follicle mites Demodex folliculorum and Demodex brevis: biology and medical importance. Dermatologica 162:1–11CrossRefPubMed

English FP, Nutting WB (1981) Demodicosis of ophthalmic concern. Am J Ophthalmol 91:362–372CrossRefPubMed

Aylesworth R, Vance JC (1982) Demodex folliculorum and Demodex brevis in cutaneous biopsies. J Am Acad Dermatol 7:583–589. https://doi.org/10.1016/S0190-9622(82)70137-9 CrossRefPubMed

Lacey N, Kavanagh K, Tseng S (2009) Under the lash: Demodex mites in human diseases. Biochem (Lond) 31:2–6

Coston T (1967) Demodex folliculorum blepharitis. Trans Am Ophthalmol Soc 65:361–392PubMedPubMedCentral

Liu J, Sheha H, Tseng SCG (2010) Pathogenic role of Demodex mites in blepharitis. Curr Opin Allergy Clin Immunol 10:505–510CrossRefPubMedPubMedCentral

Schear MJ, Milman T, Steiner T et al (2015) The association of Demodex with chalazia: a histopathologic study of the eyelid. Ophthalmic Plast Reconstr Surg 32:275–278. https://doi.org/10.1097/IOP.0000000000000500 CrossRef

English F (1971) Demodex folliculorum and oedema of the eyelash. Br J Ophthal 55:742–746CrossRef

10.

Nicholls SG, Oakley CL, Tan A, Vote BJ (2017) Demodex species in human ocular disease: new clinicopathological aspects. Int Ophthalmol 37:303–312. https://doi.org/10.1007/s10792-016-0249-9 CrossRefPubMed

11.

Gao YY, Di Pascuale MA, Li W et al (2005) High prevalence of Demodex in eyelashes with cylindrical dandruff. Investig Ophthalmol Vis Sci 46:3089–3094CrossRef

12.

Solomon A, Dursun D, Liu Z et al (2001) Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci 42:2283–2292PubMed

13.

De Paiva C, Pflugfelder S (2008) Rationale for anti-inflammatory therapy in dry eye syndrome. Arq Bras Oftalmol 71:89–95CrossRefPubMed

14.

Savini G, Prabhawasat P, Kojima T et al (2008) The challenge of dry eye diagnosis. Clin Ophthalmol 2:31–55CrossRefPubMedPubMedCentral

15.

Koo H, Kim TH, Kim KW et al (2012) Ocular surface discomfort and Demodex: effect of tea tree oil eyelid scrub in Demodex blepharitis. J Korean Med Sci 27:1574–1579CrossRefPubMedPubMedCentral

16.

Sullivan BD, Crews L, Messmer EM et al (2014) Correlations between commonly used objective signs and symptoms for the diagnosis of dry eye disease: clinical implications. Acta Ophthalmol 92:161–166CrossRefPubMed

17.

Nichols K, Nichols J, Mitchell G (2004) The lack of association between signs and symptoms in patients with dry eye disease. Cornea 23:762–770CrossRefPubMed

18.

Sullivan BDBD, Whitmer D, Nichols KKK et al (2010) An objective approach to dry eye disease severity. Investig Ophthalmol Vis Sci 51:6125–6130. https://doi.org/10.1167/iovs.10-5390 CrossRef

19.

Pult H, Purslow C, Murphy PJ (2011) The relationship between clinical signs and dry eye symptoms. Eye (Lond) 25:502–510. https://doi.org/10.1038/eye.2010.228 CrossRef

20.

Achtsidis V, Kozanidou E, Bournas P et al (2014) Dry eye and clinical disease of tear film, diagnosis and management. Eur Ophthalmic Rev 8:17–22. https://doi.org/10.17925/EOR.2014.08.01.17 CrossRef

21.

Kim JT, Lee H, Chun YS, Kim JC (2011) Tear cytokines and chemokines in patients with Demodex blepharitis. Cytokine 53:94–99CrossRefPubMed

22.

Kabataş N, Doğan AŞ, Kabataş EU et al (2017) The effect of Demodex infestation on blepharitis and the ocular symptoms. Eye Contact Lens 43:64–67CrossRefPubMed

23.

Sędzikowska A, Osęka M, Grytner-Zięcina B (2016) Ocular symptoms reported by patients infested with Demodex mites. Acta Parasitol 61:808–814CrossRef

24.

Jarmuda S, O’Reilly N, Zaba R et al (2012) Potential role of Demodex mites and bacteria in the induction of rosacea. J Med Microbiol 61:1504–1510CrossRefPubMed

25.

Sahai Malik P, Sahai A, Malik P (2005) Dry eye: prevalence and attributable risk factors in a hospital-based population. Indian J Ophthalmol 53:87–91. https://doi.org/10.4103/0301-4738.16170 CrossRefPubMed

26.

Pesudovs K, Burr JM, Harley C, Elliott DB (2007) The development, assessment, and selection of questionnaires. Optom Vis Sci 84:663–674CrossRefPubMed

27.

Willke RJ (2008) Measuring the value of treatment to patients: patient-reported outcomes in drug development. Am Heal Drug Benefits 1:34–40

28.

Schaumberg DA, Nichols JJ, Papas EB et al (2011) The international workshop on meibomian gland dysfunction: report of the subcommittee on the epidemiology of, and associated risk factors for, MGD. Investig Ophthalmol Vis Sci 52:1994–2005CrossRef

29.

World Medical Association (2013) World Medical Association declaration of Helsinki ethical principles for medical research involving human subjects. JAMA 310:2191–2194CrossRef

30.

Gao YY, Di Pascuale MA, Li W et al (2005) In vitro and in vivo killing of ocular Demodex by tea tree oil. Br J Ophthalmol 89:1468–1473. https://doi.org/10.1136/bjo.2005.072363 CrossRefPubMedPubMedCentral

31.

Mastrota KM (2013) Method to identify Demodex in the eyelash follicle without epilation. Optom Vis Sci 90:e172–e174. https://doi.org/10.1097/OPX.0b013e318294c2c0 CrossRefPubMed

32.

Wolffsohn JS, Arita R, Chalmers R et al (2017) TFOS DEWS II diagnostic methodology report. Ocul Surf 15:539–574. https://doi.org/10.1016/j.jtos.2017.05.001 CrossRefPubMed

33.

Tomlinson A, Bron AJ, Korb DR et al (2011) The international workshop on meibomian gland dysfunction: report of the diagnosis subcommittee. Investig Ophthalmol Vis Sci 52:2006–2049CrossRef

34.

Schiffman RM, Christianson MD, Jacobsen G et al (2000) Reliability and validity of the ocular surface disease index. Arch Ophthalmol 118:615. https://doi.org/10.1001/archopht.118.5.615 CrossRef

35.

Jalbert I, Rejab S (2015) Increased numbers of demodex in contact lens wearers. Optom Vis Sci 92:671–678PubMed

36.

Lee SH, Chun YS, Kim JH et al (2010) The relationship between demodex and ocular discomfort. Investig Ophthalmol Vis Sci 51:2906–2911CrossRef

37.

Walt J (2004) Ocular surface disease index (OSDI) administration and scoring manual

38.

Mathews PM, Ramulu PY, Friedman DS et al (2013) Evaluation of ocular surface disease in patients with glaucoma. Ophthalmology 120:2241–2248. https://doi.org/10.1016/j.ophtha.2013.03.045 CrossRefPubMed

39.

Miller KL, Walt JG, Mink DR et al (2010) Minimal clinically important difference for the ocular surface disease index. Arch Ophthalmol 128:94–101. https://doi.org/10.1001/archophthalmol.2009.356 (Chicago, Ill 1960) CrossRef

40.

Smith JA, Albenz J, Begley C et al (2007) The epidemiology of dry eye disease: report of the epidemiology subcommittee of the international dry eye workshop (2007). Ocul Surf 5:93–107CrossRef

41.

Bland JM, Altman DG (1997) Statistics notes: Cronbach’s alpha. BMJ. https://doi.org/10.1136/bmj.314.7080.572 CrossRefPubMedPubMedCentral

42.

Tavakol M, Dennick R (2011) Making sense of Cronbach’s alpha. Int J Med Educ 2:53–55CrossRefPubMedPubMedCentral

43.

Hallgren KA (2012) Computing inter-rater reliability for observational data: an overview and tutorial. Tutor Quant Methods Psychol 8:23–34CrossRefPubMedPubMedCentral

44.

Rosner B (2011) Fundamentals of biostatistics, 7th edn. Brooks/Cole, Boston

45.

Costello AB, Osborne JW, Costello AB (2009) Best practices in exploratory factor analysis: four recommendations for getting the most from your analysis. Pan Pacific Manag Rev 12:131–146

46.

Roth AM (1979) Demodex folliculorum in hair follicles of eyelid skin. Ann Ophthalmol 11:37–40PubMed

47.

Forton F, Seys B (1993) Density of Demodex folliculorum in rosacea: a case-control study using standardized skin-surface biopsy. Br J Dermatol 128:650–659CrossRefPubMed

48.

Randon M, Liang H, El Hamdaoui M et al (2015) In vivo confocal microscopy as a novel and reliable tool for the diagnosis of Demodex eyelid infestation. Br J Ophthalmol 99:336–341. https://doi.org/10.1136/bjophthalmol-2014-305671 CrossRefPubMed

49.

Kemal M, Sümer Z, Toker MI et al (2005) The prevalence of Demodex folliculorum in blepharitis patients and the normal population. Ophthalmic Epidemiol 12:287–290CrossRefPubMed

50.

Baima B, Sticherling M (2002) Demodicidosis revisited. Acta Derm Venereol 82:3–6CrossRefPubMed

51.

Elston DM (2010) Demodex mites: facts and controversies. Clin Dermatol 28:502–504CrossRefPubMed

52.

Lacey N, Ní Raghallaigh S, Powell FC (2011) Demodex mites–commensals, parasites or mutualistic organisms? Dermatology 222:128–130CrossRefPubMed

53.

de Venecia AB, Lim Bon Siong R (2011) Demodex sp. infestation in anterior blepharitis, meibomian-gland dysfunction, and mixed blepharitis. Philipp J Ophthalmol 36:15–22

54.

Bhandari V, Reddy JK (2014) Blepharitis: always remember demodex. Middle East Afr J Ophthalmol 21:317–320CrossRefPubMedPubMedCentral

55.

Forton F, Germaux M-A, Brasseur T et al (2005) Demodicosis and rosacea: epidemiology and significance in daily dermatologic practice. J Am Acad Dermatol 52:74–87CrossRefPubMed

56.

Villani E, Magnani F, Viola F et al (2013) In vivo confocal evaluation of the ocular surface morpho-functional unit in dry eye. Optom Vis Sci 90:576–586CrossRefPubMed

57.

Hoşal BM, Örnek N, Zilelioğlu G, Elhan AH (2005) Morphology of corneal nerves and corneal sensation in dry eye: a preliminary study. Eye 19:1276–1279CrossRefPubMed

58.

Bourcier T, Acosta MC, Borderie V et al (2005) Decreased corneal sensitivity in patients with dry eye. Investig Ophthalmol Vis Sci 46:2341CrossRef

59.

Lemp MA, Baudouin C, Baum J et al (2007) The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye work shop (2007). Ocul Surf 55:75–92

60.

Gao YY, Di Pascuale MA, Elizondo A, Tseng SC (2007) Clinical treatment of ocular demodicosis by lid scrub with tea tree oil. Cornea 26:136–143CrossRefPubMed

61.

Kheirkhah A, Casas V, Li W et al (2007) Corneal manifestations of ocular Demodex infestation. Am J Ophthalmol 143:743–749CrossRefPubMed

62.

Kojima T, Ishida R, Sato EA et al (2011) In vivo evaluation of ocular demodicosis using laser scanning confocal microscopy. Investig Ophthalmol Vis Sci 52:565–569CrossRef

63.

Georgala S, Katoulis AC, Kylafis GD et al (2001) Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea. J Eur Acad Dermatol Venereol 15:441–444CrossRefPubMed

Titel: Ocular Demodex folliculorum: prevalence and associated symptoms in an Irish population
verfasst von: Orla Murphy
Veronica O’Dwyer
Aoife Lloyd-McKernan
Publikationsdatum: 29.01.2018
Verlag: Springer Netherlands
Erschienen in: International Ophthalmology / Ausgabe 2/2019
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-018-0826-1

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