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01.04.2011 | Commentary

Of mice and men (and sheep, swine etc.): The intriguing hemodynamic and metabolic effects of hydrogen sulfide (H₂S)

verfasst von: Katja Wagner, Michael Georgieff, Pierre Asfar, Enrico Calzia, Markus W Knöferl, Peter Radermacher

Erschienen in: Critical Care | Ausgabe 2/2011

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Abstract

Whether the hydrogen sulfide (H₂S)-induced metabolic depression observed in awake rodents exists in larger species is controversial. Therefore, Derwall and colleagues exposed anesthetized and ventilated sheep to incremental H₂S concentrations by means of an extracorporeal membrane oxygenator. H₂S caused pulmonary vasoconstriction and metabolic acidosis at the highest concentration studied. Oxygen uptake and carbon dioxide production remained in the physiological range. The authors concluded that, beyond the effect of temperature, H₂S hardly modifies metabolism at all. Since the highest H₂S concentration caused toxic side effects (possibly due to an inhibition of mitochondrial respiration), the therapeutic use of inhaled H₂S should be cautioned.

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Titel: Of mice and men (and sheep, swine etc.): The intriguing hemodynamic and metabolic effects of hydrogen sulfide (H2S)
verfasst von: Katja Wagner
Michael Georgieff
Pierre Asfar
Enrico Calzia
Markus W Knöferl
Peter Radermacher
Publikationsdatum: 01.04.2011
Verlag: BioMed Central
Erschienen in: Critical Care / Ausgabe 2/2011
Elektronische ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc10079

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Of mice and men (and sheep, swine etc.): The intriguing hemodynamic and metabolic effects of hydrogen sulfide (H₂S)

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