The online version of this article (https://doi.org/10.1007/s00330-018-5461-8) contains supplementary material, which is available to authorized users.
This study aimed to investigate iron deposition and thickness and signal changes in optic radiation (OR) by enhanced T2*-weighted angiography imaging (ESWAN) in patients with relapsing-remitting multiple sclerosis (RRMS) with unilateral and bilateral lesions or no lesions.
Fifty-one RRMS patients (42 patients with a disease duration [DD] ≥ 2 years [group Mor], nine patients with a DD < 2 years [group Les]) and 51 healthy controls (group Con) underwent conventional magnetic resonance imaging (MRI) and ESWAN at 3.0 T. The mean phase value (MPV) of the OR was measured on the phase image, and thickness and signal changes of the OR were observed on the magnitude image.
The average MPVs for the OR were 1,981.55 ± 7.75 in group Mor, 1,998.45 ± 2.01 in group Les, and 2,000.48 ± 5.53 in group Con. In group Mor, 28 patients with bilateral OR lesions showed bilateral OR thinning with a heterogeneous signal, and 14 patients with unilateral OR lesions showed ipsilateral OR thinning with a heterogeneous signal. In the remaining nine patients without OR lesions and in group Con, the bilateral OR had a normal appearance. In the patients, a negative correlation was found between DD and OR thickness and a positive correlation was found between MPV and OR thickness.
We confirmed iron deposition in the OR in the RRMS patients, and the OR thickness was lower in the patients than in the controls.
• Enhanced T 2 * -weighted magnetic resonance angiography (ESWAN) provides new insights into multiple sclerosis (MS).
• Focal destruction of the optic radiation (OR) is detectable by ESWAN.
• Iron deposition in OR can be measured on ESWAN phase image in MS patients.
• OR thickness was lower in the patients than in the controls.
• Iron deposition and thickness changes of the OR are associated with disease duration.
ESM 1 (DOCX 46 kb)330_2018_5461_MOESM1_ESM.docx
Hyun JW, Park G, Kwak K et al (2017) Deep gray matter atrophy in neuromyelitis optica spectrum disorder and multiple sclerosis. Eur J Neurol 24:437–445 CrossRef
Uher T, Vaneckova M, Sormani MP et al (2017) Identification of multiple sclerosis patients at highest risk of cognitive impairment using an integrated brain magnetic resonance imaging assessment approach. Eur J Neurol 24:292–301 CrossRef
Rocca MA, Mesaros S, Preziosa P et al (2013) Wallerian and trans-synaptic degeneration contribute to optic radiation damage in multiple sclerosis: a diffusion tensor MRI study. Mult Scler 19:1610–1617 CrossRef
Takemura MY, Hori M, Yokoyama K et al (2016) Alterations of the optic pathway betweenunilateral and bilateral optic nerve damage in multiple sclerosis as revealed by the combined use of advanced diffusion kurtosis imaging and visual evoked potentials. Magn Reson Imaging 39:24–30 CrossRef
Klistorner A, Vootakuru N, Wang C et al (2015) Decoding diffusivity in multiple sclerosis: analysis of optic radiation lesional and non-lesional white matter. PLoS One 10:e0122114 CrossRef
Klistorner A, Sriram P, Vootakuru N et al (2014) Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions. Neurology 82:2165–2172 CrossRef
Kitajima M, Korogi Y, Takahashi M, Eto K (1996) MR signal intensity of the optic radiation. AJNR Am J Neuroradiol 17:1379–1383 PubMed
Chen J, Zhu L, Li H, Lu Z, Chen X, Fang S (2016) Diffusion tensor imaging of occult injury of optic radiation following optic neuritis in multiple sclerosis. Exp Ther Med 12:2505–2510 CrossRef
Kolbe SC, Marriott M, Av W et al (2012) Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis. Invest Ophthalmol Vis Sci 53:825–832 CrossRef
Mori N, Miki Y, Kasahara S et al (2009) Susceptibility-weighted imaging at 3 Tesla delineates the optic radiation. Invest Radiol 44:140–145 CrossRef
Ide S, Kakeda S, Korogi Y et al (2012) Delineation of optic radiation and stria of Gennari on high-resolution phase difference enhanced imaging. Acad Radiol 19:1283–1289 CrossRef
Sinnecker T, Oberwahrenbrock T, Metz I et al (2015) Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning-an ultrahigh-field MR pilot study. Eur Radiol 25:122–131 CrossRef
Zeng C, Chen X, Li Y et al (2013) Cerebral vein changes in relapsing-remitting multiple sclerosis demonstrated by three-dimensional enhanced T 2-weighted angiography at 3.0 T. Eur Radiol 23:869–878 CrossRef
Filippi M, Rocca MA, Ciccarelli O et al (2016) MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines. Lancet Neurol 15:292–303 CrossRef
Bian W, Harter K, Hammond-Rosenbluth KE et al (2013) A serial in vivo 7T magnetic resonance phase imaging study of white matter lesions in multiple sclerosis. Mult Scler 19:69–75 CrossRef
Chen X, Zeng C, Luo T et al (2012) Iron deposition of the deep grey matter in patients with multiple sclerosis and neuromyelitis optica: a control quantitative study by 3D-enhanced susceptibility-weighted angiography (ESWAN). Eur J Radiol 81:e633–e639 CrossRef
Du S, Sah SK, Zeng C et al (2015) Iron deposition in the gray matter in patients with relapse-remitting multiple sclerosis: A longitudinal study using three-dimensional (3D)-enhanced T 2 *-weighted angiography (ESWAN). Eur J Radiol 84:1325–1332 CrossRef
Rumzan R, Wang JJ, Zeng C et al (2013) Iron deposition in the precentral grey matter in patients with multiple sclerosis: a quantitative study using susceptibility-weighted imaging. Eur J Radiol 82:e95–e99 CrossRef
Schmalbrock P, Prakash RS, Schirda B et al (2016) Basal ganglia iron in patients with multiple sclerosis measured with 7T quantitative susceptibility mapping correlates with inhibitory control. AJNR Am J Neuroradiol 37:439–446 CrossRef
Khalil M, Langkammer C, Pichler A et al (2015) Dynamics of brain iron levels in multiple sclerosis: A longitudinal 3T MRI study. Neurology 84:2396–2402 CrossRef
Absinta M, Sati P, Schindler M et al (2016) Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions. J Clin Invest 126:2597–2609 CrossRef
Schenck JF, Zimmerman EA (2004) High-field magnetic resonance imaging of brain iron: birth of a biomarker? NMR Biomed 17:433–445 CrossRef
Khalil M, Langkammer C, Ropele S et al (2011) Determinants of brain iron in multiple sclerosis: a quantitative 3T MRI study. Neurology 77:1691–1697 CrossRef
Hammond KE, Metcalf M, Carvajal L et al (2008) Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron. Ann Neurol 64:707–713 CrossRef
Rudko DA, Solovey I, Gati JS, Kremenchutzky M, Menon RS (2014) Multiple sclerosis: improved identification of disease-relevant changes in gray and white matter by using susceptibility-based MR imaging. Radiology 272:851–864 CrossRef
Sinnecker T, Mittelstaedt P, Dörr J et al (2012) Multiple sclerosis lesions and irreversible brain tissue damage: a comparative ultrahigh-field strength magnetic resonance imaging study. Arch Neurol 69:739–745 CrossRef
Reich DS, Smith SA, Gordon-Lipkin EM et al (2009) Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability. Arch Neurol 66:998–1006 CrossRef
- Optic radiations are thinner and show signs of iron deposition in patients with long-standing remitting-relapsing multiple sclerosis: an enhanced T2*-weighted angiography imaging study
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