The online version of this article (doi:10.1186/1477-7819-10-240) contains supplementary material, which is available to authorized users.
The author declares that he has no competing interests. No grants were given for this work, and no financial benefits are expected from this work. This paper has not been presented in any form, in any forum. There is no association between the author with any commercial firm, and no grants were granted for this article. There are no competing interests in the publication of this article.
In the head and neck region, osteosarcoma is the most common primary malignant bone tumor, representing 23% of total head and neck malignancies. Osteosarcomas of the jaws are nevertheless rare lesions, representing only 2 to 10% of all osteosarcomas. This report reviews a single-center histopathology experience with craniofacial osteosarcomas, and reports the management of unusually large synchronous mandibular and maxillary osteosarcomas in a patient.
A search of the hospital pathology database for specimens with a histological diagnosis of osteosarcomas submitted between July 1992 and May 2011 was made. A chart review of a patient with large synchronous maxillary and mandibular osteosarcomas was performed, and is reported.
A 21-year-old African man with large maxillary and mandibular tumors under palliative care presented with increasing difficulties with eating, speech, and breathing. Surgical debulking was performed, with histology confirming synchronous osteosarcomas of the mandible and maxilla. The patient is well after one year, with no evidence of recurrence, having undergone no further treatment.
Osteosarcomas of the jaw remain enigmatic, and a number of difficulties related to their diagnosis and treatment are yet to be resolved. True synchronous multicentric osteosarcomas of the jaws are extremely rare but, like other osteosarcomas of the jaws, have a favorable outcome, and palliative resection of such lesions, though challenging, can therefore lead to an enormously improved quality of life and self-image, and may even offer the opportunity for cure.
Authors’ original file for figure 112957_2011_1128_MOESM1_ESM.tiff
Authors’ original file for figure 212957_2011_1128_MOESM2_ESM.tiff
Authors’ original file for figure 312957_2011_1128_MOESM3_ESM.tiff
Authors’ original file for figure 412957_2011_1128_MOESM4_ESM.tiff
Authors’ original file for figure 512957_2011_1128_MOESM5_ESM.tiff
Authors’ original file for figure 612957_2011_1128_MOESM6_ESM.tiff
Authors’ original file for figure 712957_2011_1128_MOESM7_ESM.pdf
Authors’ original file for figure 812957_2011_1128_MOESM8_ESM.pdf
Chindia ML, Swaleh SM, Godiah PM: Sarcomas of the head and neck at Kenyatta National Hospital. East Afr Med J. 2000, 77: 256-259. PubMed
Omololu AB, Ogunbiyi JO, Ogunlade SO, Alonge TO, Adebisi A, Akang EE: Primary malignant bone tumour in a tropical African University teaching hospital. West Afr J Med. 2002, 21: 291-293. PubMed
Amaral MB, Buchholz I, Freire-Maia B, Reher P, de Souza PE, Marigo Hde A, Martins CR, Horta MC: Advanced osteosarcoma of the maxilla: a case report. Med Oral Patol Oral Cir Bucal. 2008, 13: E492-E495. PubMed
Jasnau S, Meyer U, Potratz J, Jundt G, Kevric M, Joos UK, Jürgens H, Bielack SS: Cooperative Osteosarcoma Study Group COSS: Craniofacial osteosarcoma. Experience of the cooperative German-Austrian-Swiss osteosarcoma study group. Oral Oncol. 2008, 44: 286-294. 10.1016/j.oraloncology.2007.03.001. CrossRefPubMed
Chukwuneke FN, Agwuna K, Anyanechi CE: Radiological interpretation of osteosarcoma of the jaw: its relevance in clinical management. Journal of College of Medicine. 2008, 13: 39-43.
Khammissa RA, Mabusela M, Wood NH, Bouckaert M, Meyerov R, Lemmer J, Feller L: Osteosarcoma of the jaw. A brief review and a case report. SADJ. 2009, 64: 220-221. PubMed
Canadian Society of Otolaryngology-Head and Neck Surgery Oncology Study Group: Osteogenic sarcoma of the mandible and maxilla: a Canadian review (1980–2000). J Otolaryngol. 2004, 33: 139-144. CrossRef
Granados-Garcia M, Luna-Ortiz K, Castillo-Oliva HA, Villavicencio-Valencia V, Herrera-Gómez A, Mosqueda-Taylor A, Aguilar-Ponce JL, Poitevin-Chacón A: Free osseous and soft tissue surgical margins as prognostic factors in mandibular osteosarcoma. Oral Oncol. 2006, 42: 172-176. 10.1016/j.oraloncology.2005.06.027. CrossRefPubMed
- Osteosarcoma of the jaws: a review of literature and a case report on synchronous multicentric osteosarcomas
Peter M Nthumba
- BioMed Central
Neu im Fachgebiet Chirurgie
Mail Icon II