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Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery 2/2023

29.12.2022 | Clinical Report

Parotid Metastasis in a Case of Papillary Thyroid Carcinoma: Case Report and Review of Literature

verfasst von: Surendra K. Dabas, Nandini N. Menon, Himanshu Shukla, Reetesh Ranjan, Bikas Gurung, Sukirti Tiwari, Ashwani Sharma, Sahibinder Singh Bhatti, Saurabh Arora, Ajit Sinha

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Ausgabe 2/2023

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Abstract

Papillary thyroid carcinoma (PTC) is the most common differentiated thyroid neoplasm. Common sites of regional and distant metastasis includes lymph nodes, lungs and bone. 51 year old female patient who was a known case of PTC with a history of multiple surgeries, radioactive iodine therapy (RAI) and oral chemotherapy presented with a painful right parotid mass. PET scan demonstrated FDG avid lesions in the right parotid gland, cervical lymph nodes and other distant sites. Cytology report showed features of metastatic PTC. Patient underwent extended total parotidectomy with facial nerve resection, skin and masseter muscle resection and extended radical neck dissection. Final histopathology (HPE) report showed metastatic papillary carcinoma thyroid. Patient is currently on oral chemotherapy and on regular follow up. PTC rarely metastasizes to parotid gland and such cases have to be treated with surgery alone or with a combination of surgery and RAI based on tumour burden.
Literatur
1.
Zurück zum Zitat Kini H, Pai RR, Kalpana S (2003) Solitary parotid metastasis from columnar cell carcinoma of the thyroid: a diagnostic dilemma. Diagn Cytopathol 28:72–75CrossRefPubMed Kini H, Pai RR, Kalpana S (2003) Solitary parotid metastasis from columnar cell carcinoma of the thyroid: a diagnostic dilemma. Diagn Cytopathol 28:72–75CrossRefPubMed
3.
Zurück zum Zitat Randolph GW, Duh QY, Heller KS et al (2012) For the American Thyroid Association Surgical Affairs Committee’s Taskforce on Thyroid Cancer Nodal Surgery RM; the prognostic significance of nodal metastases from papillary thyroid carcinoma can be stratified based on the size and number of metastatic lymph nodes, as well as the presence of extranodal extension. Thyroid 22(11):1144–1152. https://doi.org/10.1089/thy.2012.0043CrossRefPubMed Randolph GW, Duh QY, Heller KS et al (2012) For the American Thyroid Association Surgical Affairs Committee’s Taskforce on Thyroid Cancer Nodal Surgery RM; the prognostic significance of nodal metastases from papillary thyroid carcinoma can be stratified based on the size and number of metastatic lymph nodes, as well as the presence of extranodal extension. Thyroid 22(11):1144–1152. https://​doi.​org/​10.​1089/​thy.​2012.​0043CrossRefPubMed
5.
Zurück zum Zitat Mathew PC, Balagopal PG, Thomas S, Sebastian P, Preethi TR (2007) Parotid metastasis from carcinoma of the thyroid. Int J Oral Maxillofac Surg 36:965–966CrossRefPubMed Mathew PC, Balagopal PG, Thomas S, Sebastian P, Preethi TR (2007) Parotid metastasis from carcinoma of the thyroid. Int J Oral Maxillofac Surg 36:965–966CrossRefPubMed
6.
Zurück zum Zitat Shi X, Liu R, Basolo F, Giannini R, Shen X et al (2016) Differential clinicopathological risk and prognosis of major papillary thyroid cancer variants. J Clin Endocrinol Metab 101(1):264–274CrossRefPubMed Shi X, Liu R, Basolo F, Giannini R, Shen X et al (2016) Differential clinicopathological risk and prognosis of major papillary thyroid cancer variants. J Clin Endocrinol Metab 101(1):264–274CrossRefPubMed
7.
Zurück zum Zitat Slim I, Mhiri A, Meddeb I, Goucha A, Gritli S, Ben Slimene MF (2012) Malar bone metastasis revealing a papillary thyroid carcinoma. Case Rep Otolaryngol 2012:795686PubMedPubMedCentral Slim I, Mhiri A, Meddeb I, Goucha A, Gritli S, Ben Slimene MF (2012) Malar bone metastasis revealing a papillary thyroid carcinoma. Case Rep Otolaryngol 2012:795686PubMedPubMedCentral
8.
Zurück zum Zitat Chen H, Luo D, Zhang L, Lin X, Luo Q, Yi H, Wang J, Yan X, Li B, Chen Y, Liu X, Zhang H, Liu S, Qiu M, Yang D, Jiang N (2017) Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells. Oncotarget 8(26):43008–43022CrossRefPubMedPubMedCentral Chen H, Luo D, Zhang L, Lin X, Luo Q, Yi H, Wang J, Yan X, Li B, Chen Y, Liu X, Zhang H, Liu S, Qiu M, Yang D, Jiang N (2017) Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells. Oncotarget 8(26):43008–43022CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Pagano L, Caputo M, Sama MT, Zavattaro M, Prodam F, Mauri MG, Pia F, Alonzo A, Valente G, Aimaretti G (2013) Unusual metastases from tall cell variant of papillary thyroid cancer. Head Neck 35:E381–E385CrossRefPubMed Pagano L, Caputo M, Sama MT, Zavattaro M, Prodam F, Mauri MG, Pia F, Alonzo A, Valente G, Aimaretti G (2013) Unusual metastases from tall cell variant of papillary thyroid cancer. Head Neck 35:E381–E385CrossRefPubMed
11.
Zurück zum Zitat Ibrahimpasic T, Ghossein R, Carlson DL, Nixon I, Palmer FL, Shaha AR, Patel SG, Tuttle RM, Shah JP, Ganly I (2014) Outcomes in patients with poorly differentiated thyroid carcinoma. J Clin Endocrinol Metab 99(4):1245–1252CrossRefPubMed Ibrahimpasic T, Ghossein R, Carlson DL, Nixon I, Palmer FL, Shaha AR, Patel SG, Tuttle RM, Shah JP, Ganly I (2014) Outcomes in patients with poorly differentiated thyroid carcinoma. J Clin Endocrinol Metab 99(4):1245–1252CrossRefPubMed
12.
Zurück zum Zitat Wu ZH, Ge MH, Cao J, Lan XB, Zhu XH, Huang YQ, Yu B (2017) Parotid metastases from thyroid carcinomas. Int J Clin Exp Pathol 10(10):10467–10474PubMedPubMedCentral Wu ZH, Ge MH, Cao J, Lan XB, Zhu XH, Huang YQ, Yu B (2017) Parotid metastases from thyroid carcinomas. Int J Clin Exp Pathol 10(10):10467–10474PubMedPubMedCentral
16.
Zurück zum Zitat Farahmandfar F, Shakeri S, Askari E et al (2020) Parotid metastasis as the first presentation of papillary thyroid carcinoma. Iran J Nucl Med 28(2):42–45 Farahmandfar F, Shakeri S, Askari E et al (2020) Parotid metastasis as the first presentation of papillary thyroid carcinoma. Iran J Nucl Med 28(2):42–45
17.
Zurück zum Zitat Alzaraa A, Stone J, Williams G, Ahmed I, Quraishi M (2008) Direct spread of thyroid follicular carcinoma to the parotid gland and the internal jugular vein: a case report. J Med Case Rep 2:297CrossRefPubMedPubMedCentral Alzaraa A, Stone J, Williams G, Ahmed I, Quraishi M (2008) Direct spread of thyroid follicular carcinoma to the parotid gland and the internal jugular vein: a case report. J Med Case Rep 2:297CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Pelosi S, Genden EM (2009) Medullary thyroid carcinoma metastatic to the parotid gland. Laryngoscope 119:253CrossRef Pelosi S, Genden EM (2009) Medullary thyroid carcinoma metastatic to the parotid gland. Laryngoscope 119:253CrossRef
19.
Zurück zum Zitat Conway A, Wiernik A, Rawal A, Lam C, Mesa H (2012) Occult primary medullary thyroid carcinoma presenting with pituitary and parotid metastases: case report and review of the literature. Endocr pathol 23:115–122CrossRefPubMed Conway A, Wiernik A, Rawal A, Lam C, Mesa H (2012) Occult primary medullary thyroid carcinoma presenting with pituitary and parotid metastases: case report and review of the literature. Endocr pathol 23:115–122CrossRefPubMed
20.
Zurück zum Zitat Zikos P, Vafiadou M, Kechagias N, Vahtsevanos K, Mangoudi D (2013) Metastases to the parotid gland from a medullary thyroid carcinoma (case report). Oral Oncol 49:143CrossRef Zikos P, Vafiadou M, Kechagias N, Vahtsevanos K, Mangoudi D (2013) Metastases to the parotid gland from a medullary thyroid carcinoma (case report). Oral Oncol 49:143CrossRef
21.
Zurück zum Zitat Garca-Arns JA, Maldonado C, Fernndez R, Gonzalo M (2014) Thyroid papillary microcarcinoma presenting as parotid metastasis: a case report. Endocr Abstr 35:331 Garca-Arns JA, Maldonado C, Fernndez R, Gonzalo M (2014) Thyroid papillary microcarcinoma presenting as parotid metastasis: a case report. Endocr Abstr 35:331
22.
Zurück zum Zitat Wexler JA (2011) Approach to the thyroid cancer patient with bone metastases. J Clin Endocrinol Metab 96:2296–2307CrossRefPubMed Wexler JA (2011) Approach to the thyroid cancer patient with bone metastases. J Clin Endocrinol Metab 96:2296–2307CrossRefPubMed
Metadaten
Titel
Parotid Metastasis in a Case of Papillary Thyroid Carcinoma: Case Report and Review of Literature
verfasst von
Surendra K. Dabas
Nandini N. Menon
Himanshu Shukla
Reetesh Ranjan
Bikas Gurung
Sukirti Tiwari
Ashwani Sharma
Sahibinder Singh Bhatti
Saurabh Arora
Ajit Sinha
Publikationsdatum
29.12.2022
Verlag
Springer India
Erschienen in
Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe 2/2023
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI
https://doi.org/10.1007/s12070-022-03425-2

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