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International Journal of Legal Medicine

Erschienen in:

01.07.2011 | Original Article

Pedigree likelihood ratio for lineage markers

verfasst von: Jianye Ge, Arthur Eisenberg, Jiangwei Yan, Ranajit Chakraborty, Bruce Budowle

Erschienen in: International Journal of Legal Medicine | Ausgabe 4/2011

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Abstract

Lineage-based haplotype markers (e.g., Y chromosome STRs and mitochondrial DNA sequences) are important adjunct tools to the autosomal markers for kinship analysis and for specialized kinship applications such as database searching. Traditionally, the prosecution or kinship hypothesis considers the haplotypes in the same lineage and the probability of genotype data given the lineage hypothesis is simply set at 1 if the number of mismatched loci or nucleotides between the questioned person and the references is less than a predefined threshold. In this study, a kinship hypothesis based on a fixed relationship of the questioned person in the reference family is introduced. A graphical model is proposed to calculate the probability of the genotype data given the kinship hypothesis, which is the product of haplotype frequency of the founder in the pedigree and the transmission probability from the founder to all descendants. Proper mutation models are suggested for Y chromosome STRs and mitochondrial DNA sequence variants (i.e., SNPs) to calculate the transmission probability. The methods to infer the genotypes of the untyped individuals in the pedigree and the computational complexity of handling these untyped individuals are also addressed. Lastly, numerical examples of the applications are given to demonstrate the kinship hypothesis and the algorithms.

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Titel: Pedigree likelihood ratio for lineage markers
verfasst von: Jianye Ge
Arthur Eisenberg
Jiangwei Yan
Ranajit Chakraborty
Bruce Budowle
Publikationsdatum: 01.07.2011
Verlag: Springer-Verlag
Erschienen in: International Journal of Legal Medicine / Ausgabe 4/2011
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-010-0514-9

Springer Medizin

Pedigree likelihood ratio for lineage markers

Abstract

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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