Skip to main content
Erschienen in: Skeletal Radiology 6/2020

01.06.2020 | Scientific Article

Performance of a rapid two-sequence screening protocol for osteomyelitis of the foot

verfasst von: Adam D. Singer, Monica Umpierrez, Aparna Kakarala, Marcos C. Schechter, Michael Maceroli, Gulshan B. Sharma, Ravi R. Rajani

Erschienen in: Skeletal Radiology | Ausgabe 6/2020

Einloggen, um Zugang zu erhalten

Abstract

Objective

Compare a two sequence protocol to a standard protocol in the detection of pedal osteomyelitis (OM) and abscesses and to identify patients that benefit from a full protocol.

Materials and methods

One hundred thirty-two foot MRIs ordered to assess for OM were enrolled, and the following items were extracted from the clinical reports: use of IV contrast, the presence of OM, reactive osteitis, and a soft tissue abscess. Using only one T1 nonfat-suppressed and one fluid sensitive fat-suppressed sequences, two experienced musculoskeletal radiologists reviewed each case for the presence of OM, reactive osteitis, or an abscess. A Kappa test was calculated to assess for interobserver agreement, and diagnostic performance was determined. The McNemar test was used to assess for the effect of contrast.

Results

Agreement between both observers and the clinical report on the presence of osteomyelitis was substantial ( k = 0.63 and 0.72, p < 0.001), while the agreement for abscess was fair (k = 0.29 and 0.38, p < 0.001). For osteomyelitis, both observers showed good accuracy (0.85 and 0.86). When screening bone for a normal versus abnormal case, this method was highly sensitive (0.97–0.98), but was less sensitive for abscess (0.63–0.75). Fifty-one percent of exams used contrast, and it did impact the diagnosis of abscess for one observer.

Conclusion

This rapid protocol is accurate in making the diagnosis of OM, and its high sensitivity makes it useful to screen for patients that would benefit from a full protocol.
Literatur
1.
Zurück zum Zitat Geraghty T, LaPorta G. Current health and economic burden of chronic diabetic osteomyelitis. Expert Rev Pharmacoecon Outcomes Res. 2019;19(3):279–86.CrossRef Geraghty T, LaPorta G. Current health and economic burden of chronic diabetic osteomyelitis. Expert Rev Pharmacoecon Outcomes Res. 2019;19(3):279–86.CrossRef
2.
Zurück zum Zitat Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376(24):2367–75.CrossRef Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376(24):2367–75.CrossRef
3.
Zurück zum Zitat Schweitzer ME, Daffner RH, Weissman BN, Bennett DL, Blebea JS, Jacobson JA, et al. ACR appropriateness criteria on suspected osteomyelitis in patients with diabetes mellitus. J Am Coll Radiol. 2008;5(8):881–6.CrossRef Schweitzer ME, Daffner RH, Weissman BN, Bennett DL, Blebea JS, Jacobson JA, et al. ACR appropriateness criteria on suspected osteomyelitis in patients with diabetes mellitus. J Am Coll Radiol. 2008;5(8):881–6.CrossRef
4.
Zurück zum Zitat Al-Khawari HA, Al-Saeed OM, Jumaa TH, Chishti F. Evaluating diabetic foot infection with magnetic resonance imaging: Kuwait experience. Med Princ Pract. 2005;14(3):165–72.CrossRef Al-Khawari HA, Al-Saeed OM, Jumaa TH, Chishti F. Evaluating diabetic foot infection with magnetic resonance imaging: Kuwait experience. Med Princ Pract. 2005;14(3):165–72.CrossRef
5.
Zurück zum Zitat Ledermann HP, Morrison WB, Schweitzer ME. Pedal abscesses in patients suspected of having pedal osteomyelitis: analysis with MR imaging. Radiology. 2002;224(3):649–55.CrossRef Ledermann HP, Morrison WB, Schweitzer ME. Pedal abscesses in patients suspected of having pedal osteomyelitis: analysis with MR imaging. Radiology. 2002;224(3):649–55.CrossRef
6.
Zurück zum Zitat Kapoor A, Page S, Lavalley M, Gale DR, Felson DT. Magnetic resonance imaging for diagnosing foot osteomyelitis: a meta-analysis. Arch Intern Med. 2007;167(2):125–32.CrossRef Kapoor A, Page S, Lavalley M, Gale DR, Felson DT. Magnetic resonance imaging for diagnosing foot osteomyelitis: a meta-analysis. Arch Intern Med. 2007;167(2):125–32.CrossRef
7.
Zurück zum Zitat Mahendra M, Singh R. Diagnostic accuracy and surgical utility of MRI in complicated diabetic foot. J Clin Diagn Res. 2017;11(7):RC01–4.PubMedPubMedCentral Mahendra M, Singh R. Diagnostic accuracy and surgical utility of MRI in complicated diabetic foot. J Clin Diagn Res. 2017;11(7):RC01–4.PubMedPubMedCentral
8.
Zurück zum Zitat Chow I, Lemos EV, Einarson TR. Management and prevention of diabetic foot ulcers and infections: a health economic review. Pharmacoeconomics. 2008;26(12):1019–35.CrossRef Chow I, Lemos EV, Einarson TR. Management and prevention of diabetic foot ulcers and infections: a health economic review. Pharmacoeconomics. 2008;26(12):1019–35.CrossRef
9.
Zurück zum Zitat Kan JH, Estrada C, Hasan U, Bracikowski A, Shyr Y, Shakhtour B, et al. Management of occult fractures in the skeletally immature patient: cost analysis of implementing a limited trauma magnetic resonance imaging protocol. Pediatr Emerg Care. 2009;25(4):226–30.CrossRef Kan JH, Estrada C, Hasan U, Bracikowski A, Shyr Y, Shakhtour B, et al. Management of occult fractures in the skeletally immature patient: cost analysis of implementing a limited trauma magnetic resonance imaging protocol. Pediatr Emerg Care. 2009;25(4):226–30.CrossRef
10.
Zurück zum Zitat May LA, Chen DC, Bui-Mansfield LT, O'Brien SD. Rapid magnetic resonance imaging evaluation of femoral neck stress fractures in a U.S. active duty military population. Mil Med. 2017;182(1):e1619–25.CrossRef May LA, Chen DC, Bui-Mansfield LT, O'Brien SD. Rapid magnetic resonance imaging evaluation of femoral neck stress fractures in a U.S. active duty military population. Mil Med. 2017;182(1):e1619–25.CrossRef
11.
Zurück zum Zitat May DA, Disler DG. Screening for avascular necrosis of the hip with rapid MRI: preliminary experience. J Comput Assist Tomogr. 2000;24(2):284–7.CrossRef May DA, Disler DG. Screening for avascular necrosis of the hip with rapid MRI: preliminary experience. J Comput Assist Tomogr. 2000;24(2):284–7.CrossRef
12.
Zurück zum Zitat Ross AB, Chan BY, Yi PH, Repplinger MD, Vanness DJ, Lee KS. Diagnostic accuracy of an abbreviated MRI protocol for detecting radiographically occult hip and pelvis fractures in the elderly. Skelet Radiol. 2019;48(1):103–8.CrossRef Ross AB, Chan BY, Yi PH, Repplinger MD, Vanness DJ, Lee KS. Diagnostic accuracy of an abbreviated MRI protocol for detecting radiographically occult hip and pelvis fractures in the elderly. Skelet Radiol. 2019;48(1):103–8.CrossRef
13.
Zurück zum Zitat Khurana B, Okanobo H, Ossiani M, Ledbetter S, Al Dulaimy K, Sodickson A. Abbreviated MRI for patients presenting to the emergency department with hip pain. AJR Am J Roentgenol. 2012;198(6):W581–8.CrossRef Khurana B, Okanobo H, Ossiani M, Ledbetter S, Al Dulaimy K, Sodickson A. Abbreviated MRI for patients presenting to the emergency department with hip pain. AJR Am J Roentgenol. 2012;198(6):W581–8.CrossRef
14.
Zurück zum Zitat Khoury NJ, Birjawi GA, Chaaya M, Hourani MH. Use of limited MR protocol (coronal STIR) in the evaluation of patients with hip pain. Skelet Radiol. 2003;32(10):567–74.CrossRef Khoury NJ, Birjawi GA, Chaaya M, Hourani MH. Use of limited MR protocol (coronal STIR) in the evaluation of patients with hip pain. Skelet Radiol. 2003;32(10):567–74.CrossRef
15.
Zurück zum Zitat Kotecha HM, Lo HS, Vedantham S, Shin H, Cerniglia CA. Abbreviated MRI of the foot in patients with suspected osteomyelitis. Emerg Radiol. 2019. Kotecha HM, Lo HS, Vedantham S, Shin H, Cerniglia CA. Abbreviated MRI of the foot in patients with suspected osteomyelitis. Emerg Radiol. 2019.
16.
Zurück zum Zitat Hallgren KA. Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Tutor Quant Methods Psychol. 2012;8(1):23–34. Hallgren KA.  Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial.  Tutor Quant Methods Psychol. 2012;8(1):23–34.
17.
Zurück zum Zitat Duryea D, Bernard S, Flemming D, Walker E, French C. Outcomes in diabetic foot ulcer patients with isolated T2 marrow signal abnormality in the underlying bone: should the diagnosis of "osteitis" be changed to "early osteomyelitis"? Skelet Radiol. 2017;46(10):1327–33.CrossRef Duryea D, Bernard S, Flemming D, Walker E, French C. Outcomes in diabetic foot ulcer patients with isolated T2 marrow signal abnormality in the underlying bone: should the diagnosis of "osteitis" be changed to "early osteomyelitis"? Skelet Radiol. 2017;46(10):1327–33.CrossRef
18.
Zurück zum Zitat Ledermann HP, Schweitzer ME, Morrison WB. Nonenhancing tissue on MR imaging of pedal infection: characterization of necrotic tissue and associated limitations for diagnosis of osteomyelitis and abscess. AJR Am J Roentgenol. 2002;178(1):215–22.CrossRef Ledermann HP, Schweitzer ME, Morrison WB. Nonenhancing tissue on MR imaging of pedal infection: characterization of necrotic tissue and associated limitations for diagnosis of osteomyelitis and abscess. AJR Am J Roentgenol. 2002;178(1):215–22.CrossRef
19.
Zurück zum Zitat Morrison WB, Schweitzer ME, Wapner KL, Hecht PJ, Gannon FH, Behm WR. Osteomyelitis in feet of diabetics: clinical accuracy, surgical utility, and cost-effectiveness of MR imaging. Radiology. 1995;196(2):557–64.CrossRef Morrison WB, Schweitzer ME, Wapner KL, Hecht PJ, Gannon FH, Behm WR. Osteomyelitis in feet of diabetics: clinical accuracy, surgical utility, and cost-effectiveness of MR imaging. Radiology. 1995;196(2):557–64.CrossRef
20.
Zurück zum Zitat Meyr AJ, Singh S, Zhang X, Khilko N, Mukherjee A, Sheridan MJ, et al. Statistical reliability of bone biopsy for the diagnosis of diabetic foot osteomyelitis. J Foot Ankle Surg. 2011;50(6):663–7.CrossRef Meyr AJ, Singh S, Zhang X, Khilko N, Mukherjee A, Sheridan MJ, et al. Statistical reliability of bone biopsy for the diagnosis of diabetic foot osteomyelitis. J Foot Ankle Surg. 2011;50(6):663–7.CrossRef
21.
Zurück zum Zitat Chadayammuri V, Herbert B, Hao J, Mavrogenis A, Quispe JC, Kim JW, et al. Diagnostic accuracy of various modalities relative to open bone biopsy for detection of long bone posttraumatic osteomyelitis. Eur J Orthop Surg Traumatol. 2017;27(7):871–5.CrossRef Chadayammuri V, Herbert B, Hao J, Mavrogenis A, Quispe JC, Kim JW, et al. Diagnostic accuracy of various modalities relative to open bone biopsy for detection of long bone posttraumatic osteomyelitis. Eur J Orthop Surg Traumatol. 2017;27(7):871–5.CrossRef
22.
Zurück zum Zitat Elmarsafi T, Kumar A, Cooper PS, Steinberg JS, Evans KK, Attinger CE, et al. Concordance between bone pathology and bone culture for the diagnosis of osteomyelitis in the presence of Charcot neuro-osteoarthropathy. J Foot Ankle Surg. 2018;57(5):919–23.CrossRef Elmarsafi T, Kumar A, Cooper PS, Steinberg JS, Evans KK, Attinger CE, et al. Concordance between bone pathology and bone culture for the diagnosis of osteomyelitis in the presence of Charcot neuro-osteoarthropathy. J Foot Ankle Surg. 2018;57(5):919–23.CrossRef
23.
Zurück zum Zitat Meyr AJ, Seo K, Khurana JS, Choksi R, Chakraborty B. Level of agreement with a multi-test approach to the diagnosis of diabetic foot osteomyelitis. J Foot Ankle Surg. 2018;57(6):1137–9.CrossRef Meyr AJ, Seo K, Khurana JS, Choksi R, Chakraborty B. Level of agreement with a multi-test approach to the diagnosis of diabetic foot osteomyelitis. J Foot Ankle Surg. 2018;57(6):1137–9.CrossRef
24.
Zurück zum Zitat Ramanujam CL, Han D, Zgonis T. Medical imaging and laboratory analysis of diagnostic accuracy in 107 consecutive hospitalized patients with diabetic foot osteomyelitis and partial foot amputations. Foot Ankle Spec. 2018;11(5):433–43.CrossRef Ramanujam CL, Han D, Zgonis T. Medical imaging and laboratory analysis of diagnostic accuracy in 107 consecutive hospitalized patients with diabetic foot osteomyelitis and partial foot amputations. Foot Ankle Spec. 2018;11(5):433–43.CrossRef
Metadaten
Titel
Performance of a rapid two-sequence screening protocol for osteomyelitis of the foot
verfasst von
Adam D. Singer
Monica Umpierrez
Aparna Kakarala
Marcos C. Schechter
Michael Maceroli
Gulshan B. Sharma
Ravi R. Rajani
Publikationsdatum
01.06.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Skeletal Radiology / Ausgabe 6/2020
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-019-03367-x

Weitere Artikel der Ausgabe 6/2020

Skeletal Radiology 6/2020 Zur Ausgabe

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

S3-Leitlinie zu Pankreaskrebs aktualisiert

23.04.2024 Pankreaskarzinom Nachrichten

Die Empfehlungen zur Therapie des Pankreaskarzinoms wurden um zwei Off-Label-Anwendungen erweitert. Und auch im Bereich der Früherkennung gibt es Aktualisierungen.

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

18.04.2024 Pädiatrische Notfallmedizin Nachrichten

Im Choosing-Wisely-Programm, das für die deutsche Initiative „Klug entscheiden“ Pate gestanden hat, sind erstmals Empfehlungen zum Umgang mit Notfällen von Kindern erschienen. Fünf Dinge gilt es demnach zu vermeiden.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.