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Erschienen in: Current Anesthesiology Reports 4/2023

26.09.2023 | Pediatric Anesthesia (R Agarwal, Section Editor)

Perioperative Pain Management After Posterior Spinal Fusion for Idiopathic Scoliosis

verfasst von: McKenzee Murdock, Jared R. E. Hylton

Erschienen in: Current Anesthesiology Reports | Ausgabe 4/2023

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Abstract

Purpose of Review

To review and summarize current evidence for analgesic modalities after adolescent posterior spinal fusion (PSF) with an emphasis on recent updates in the literature.

Recent Findings

Opioid patient-controlled analgesia (PCA) continues to be the cornerstone of most analgesic protocols. The recent introduction of new approaches to opioid-sparing analgesic modalities, including scheduled methadone, new regional anesthetic techniques, and novel multimodal analgesics, continues to be explored for efficacy in adolescent PSF.

Summary

While many analgesic approaches have limited data, some new techniques have shown significant potential in reducing opioid use and improving the quality of analgesia for pediatric PSF. Further comparative studies will hopefully address the knowledge gaps identified in this narrative review.
Literatur
1.
Zurück zum Zitat Kwan MK, Chiu CK, Chan TS, et al. Trajectory of postoperative wound pain within the first 2 weeks following posterior spinal fusion surgery in adolescent idiopathic scoliosis patients. Spine. 2017;42(11):838–43.PubMedCrossRef Kwan MK, Chiu CK, Chan TS, et al. Trajectory of postoperative wound pain within the first 2 weeks following posterior spinal fusion surgery in adolescent idiopathic scoliosis patients. Spine. 2017;42(11):838–43.PubMedCrossRef
2.
Zurück zum Zitat Rabbitts JA, Palermo TM, Zhou C, et al. Pain and health-related quality of life after pediatric inpatient surgery. J Pain. 2015;16(12):1334–41.PubMedPubMedCentralCrossRef Rabbitts JA, Palermo TM, Zhou C, et al. Pain and health-related quality of life after pediatric inpatient surgery. J Pain. 2015;16(12):1334–41.PubMedPubMedCentralCrossRef
3.
Zurück zum Zitat Chidambaran V, Ding L, Moore DL, et al. Predicting the pain continuum after adolescent idiopathic scoliosis surgery: a prospective cohort study. Eur J Pain. 2017;21(7):1252–65.PubMedPubMedCentralCrossRef Chidambaran V, Ding L, Moore DL, et al. Predicting the pain continuum after adolescent idiopathic scoliosis surgery: a prospective cohort study. Eur J Pain. 2017;21(7):1252–65.PubMedPubMedCentralCrossRef
4.
Zurück zum Zitat Kehlet H, Dahl JB. The value of “multimodal” or “balanced analgesia” in postoperative pain treatment. Anesth Analg. 1993;77(5):1048–56.PubMed Kehlet H, Dahl JB. The value of “multimodal” or “balanced analgesia” in postoperative pain treatment. Anesth Analg. 1993;77(5):1048–56.PubMed
5.
Zurück zum Zitat Kim DJ, Bengali R, Anderson TA. Opioid-free anesthesia using continuous dexmedetomidine and lidocaine infusions in spine surgery. Korean J Anesthesiol. 2017;70(6):652–3. Kim DJ, Bengali R, Anderson TA. Opioid-free anesthesia using continuous dexmedetomidine and lidocaine infusions in spine surgery. Korean J Anesthesiol. 2017;70(6):652–3.
6.
7.
Zurück zum Zitat Gaukroger PB, Tomkins DP, van der Walt JH. Patient-controlled analgesia in children. Anaesth Intensive Care. 1989;17:264–8.PubMedCrossRef Gaukroger PB, Tomkins DP, van der Walt JH. Patient-controlled analgesia in children. Anaesth Intensive Care. 1989;17:264–8.PubMedCrossRef
8.
Zurück zum Zitat Berde CB, Lehn BM, Yee JD, et al. Patient-controlled analgesia in children and adolescents: a randomized, prospective comparison with intramuscular administration of morphine for postoperative analgesia. J Pediar. 1991;118:460–6.CrossRef Berde CB, Lehn BM, Yee JD, et al. Patient-controlled analgesia in children and adolescents: a randomized, prospective comparison with intramuscular administration of morphine for postoperative analgesia. J Pediar. 1991;118:460–6.CrossRef
9.
Zurück zum Zitat Palmer GM, Pirakalathanan P, Skinner AV. A multi-centre multi-national survey of anaesthetists regarding the range of anaesthetic and surgical practices for paediatric scoliosis surgery. Anaesth Intensive Care. 2010;38:1077–84.PubMedCrossRef Palmer GM, Pirakalathanan P, Skinner AV. A multi-centre multi-national survey of anaesthetists regarding the range of anaesthetic and surgical practices for paediatric scoliosis surgery. Anaesth Intensive Care. 2010;38:1077–84.PubMedCrossRef
10.
Zurück zum Zitat Cassady JF, Lederhaas G, Cancel DD, et al. A randomized comparison of the effects of continuous thoracic epidural analgesia and intravenous patient-controlled analgesia after posterior spinal fusion in adolescents. Reg Anesthe Pain Med. 2000;25:246–53. Cassady JF, Lederhaas G, Cancel DD, et al. A randomized comparison of the effects of continuous thoracic epidural analgesia and intravenous patient-controlled analgesia after posterior spinal fusion in adolescents. Reg Anesthe Pain Med. 2000;25:246–53.
11.
Zurück zum Zitat Sucato DJ, Duey-Holtz A, Elerson E, et al. Postoperative analgesia following surgical correction for adolescent idiopathic scoliosis: a comparison of continuous epidural analgesia and patient-controlled analgesia. Spine (Phila Pa 1976). 2005;30:211–7.PubMedCrossRef Sucato DJ, Duey-Holtz A, Elerson E, et al. Postoperative analgesia following surgical correction for adolescent idiopathic scoliosis: a comparison of continuous epidural analgesia and patient-controlled analgesia. Spine (Phila Pa 1976). 2005;30:211–7.PubMedCrossRef
12.
Zurück zum Zitat Gauger VT, Voepel Lewis TD, Burke CN, et al. Epidural analgesia compared with intravenous analgesia after pediatric posterior spinal fusion. J Pediatr Orthop. 2009;29(6):588–93.PubMedCrossRef Gauger VT, Voepel Lewis TD, Burke CN, et al. Epidural analgesia compared with intravenous analgesia after pediatric posterior spinal fusion. J Pediatr Orthop. 2009;29(6):588–93.PubMedCrossRef
13.
Zurück zum Zitat Pestieau SR, Finkel JC, Junqueira MM, et al. Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery. Paediatr Anaesth. 2014;24(6):582–90.PubMedCrossRef Pestieau SR, Finkel JC, Junqueira MM, et al. Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery. Paediatr Anaesth. 2014;24(6):582–90.PubMedCrossRef
14.
Zurück zum Zitat Arnold JH, Truog RD, Orav EJ, et al. Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology. 1990;73(6):1136–40.PubMedCrossRef Arnold JH, Truog RD, Orav EJ, et al. Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology. 1990;73(6):1136–40.PubMedCrossRef
15.
Zurück zum Zitat Katz R, Kelly HW, His A. Prospective study on the occurrence of withdrawal in critically ill children who receive fentanyl by continuous infusion. Crit Care Med. 1994;22(5):763–7.PubMedCrossRef Katz R, Kelly HW, His A. Prospective study on the occurrence of withdrawal in critically ill children who receive fentanyl by continuous infusion. Crit Care Med. 1994;22(5):763–7.PubMedCrossRef
16.
Zurück zum Zitat Karl HW, Tyler DC, Miser AW. Controlled trial of morphine vs hydromorphone for patient-controlled analgesia in children with postoperative pain. Pain Med. 2012;13(12):1658–9.PubMedCrossRef Karl HW, Tyler DC, Miser AW. Controlled trial of morphine vs hydromorphone for patient-controlled analgesia in children with postoperative pain. Pain Med. 2012;13(12):1658–9.PubMedCrossRef
17.
Zurück zum Zitat Felden L, Walter C, Harder S, et al. Comparative clinical effects of hydromorphone and morphine: a meta-analysis. Br J Anaesth. 2011;107(3):319–28.PubMedCrossRef Felden L, Walter C, Harder S, et al. Comparative clinical effects of hydromorphone and morphine: a meta-analysis. Br J Anaesth. 2011;107(3):319–28.PubMedCrossRef
18.
Zurück zum Zitat Hayes J, Dowling JJ, Peliowski A, et al. Patient-controlled analgesia plus background opioid infusion for postoperative pain in children: a systematic review and meta-analysis of randomized trials. Anesth Analg. 2016;123(4):991.PubMedCrossRef Hayes J, Dowling JJ, Peliowski A, et al. Patient-controlled analgesia plus background opioid infusion for postoperative pain in children: a systematic review and meta-analysis of randomized trials. Anesth Analg. 2016;123(4):991.PubMedCrossRef
19.
Zurück zum Zitat Weldon BC, Connor M, White PF. Pediatric PCA: the role of concurrent opioid infusions and nurse-controlled analgesia. Clin J Pain. 1993;9:26–33.PubMedCrossRef Weldon BC, Connor M, White PF. Pediatric PCA: the role of concurrent opioid infusions and nurse-controlled analgesia. Clin J Pain. 1993;9:26–33.PubMedCrossRef
20.••
Zurück zum Zitat Cravero JP, Agarwal R, Berde C, et al. The Society for Pediatric Anesthesia recommendations for the use of opioids in children during the perioperative period. Paediatr Anaesth. 2019;29(6):547–71. An evidence-based and expert consensus guideline for use of opioids in children within the perioperative period by the Society of Pediatric Anesthesia (SPA).PubMedPubMedCentralCrossRef Cravero JP, Agarwal R, Berde C, et al. The Society for Pediatric Anesthesia recommendations for the use of opioids in children during the perioperative period. Paediatr Anaesth. 2019;29(6):547–71. An evidence-based and expert consensus guideline for use of opioids in children within the perioperative period by the Society of Pediatric Anesthesia (SPA).PubMedPubMedCentralCrossRef
21.••
Zurück zum Zitat Mok V, Sweetman S, Hernandez B, et al. Scheduled methadone reduces overall opioid requirements after pediatric posterior spinal fusion: a single center retrospective case series. Paediatr Anaesth. 2022;32(10):1159–65. A recent study that reported a significant decrease in perioperative opioid use with an innovative scheduled methadone protocol based on methadone pharmacokinetics.PubMedCrossRef Mok V, Sweetman S, Hernandez B, et al. Scheduled methadone reduces overall opioid requirements after pediatric posterior spinal fusion: a single center retrospective case series. Paediatr Anaesth. 2022;32(10):1159–65. A recent study that reported a significant decrease in perioperative opioid use with an innovative scheduled methadone protocol based on methadone pharmacokinetics.PubMedCrossRef
22.
Zurück zum Zitat Fletcher ND, Andras LM, Lazarus DE, et al. Use of a novel pathway for early discharge was associated with a 48% shorter length of stay after posterior spinal fusion for adolescent idiopathic scoliosis. J Pediatr Orthop. 2017;37(2):92–7.PubMedCrossRef Fletcher ND, Andras LM, Lazarus DE, et al. Use of a novel pathway for early discharge was associated with a 48% shorter length of stay after posterior spinal fusion for adolescent idiopathic scoliosis. J Pediatr Orthop. 2017;37(2):92–7.PubMedCrossRef
23.
Zurück zum Zitat Codd EE, Shank RP, Schupsky JJ, et al. Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther. 1995;274(3):1263–70.PubMed Codd EE, Shank RP, Schupsky JJ, et al. Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther. 1995;274(3):1263–70.PubMed
24.
Zurück zum Zitat Packiasabapathy S, Aruldhas BW, Horn N, et al. Pharmacogenonmics of methadone: a narrative review of the literature. Pharmacogenomics. 2020;21(12):871–87.PubMedPubMedCentralCrossRef Packiasabapathy S, Aruldhas BW, Horn N, et al. Pharmacogenonmics of methadone: a narrative review of the literature. Pharmacogenomics. 2020;21(12):871–87.PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat Silverman SM. Opioid induced hyperalgesia: clinical implications for the pain practitioner. Pain Physician. 2009;12(3):679–84.PubMedCrossRef Silverman SM. Opioid induced hyperalgesia: clinical implications for the pain practitioner. Pain Physician. 2009;12(3):679–84.PubMedCrossRef
26.
Zurück zum Zitat Stemland CJ, Witte J, Colquhoun DA, et al. The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion. Paediatr Anaesth. 2013;23(1):51–7.PubMedCrossRef Stemland CJ, Witte J, Colquhoun DA, et al. The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion. Paediatr Anaesth. 2013;23(1):51–7.PubMedCrossRef
27.•
Zurück zum Zitat Sadhasivam S, Aruldhas BW, Packiasabapathy S, et al. A novel perioperative multidose methadone-based multimodal analgesic strategy in children achieved safe and low analgesic blood methadone levels enabling opioid-sparing sustained analgesia with minimal adverse effects. Anesth Analg. 2021;133:327–37. A novel study that examined low-dose scheduled methadone and analyzed opioid consumption and plasma methadone levels for spinal fusion and pectus excavatum surgery.PubMedPubMedCentralCrossRef Sadhasivam S, Aruldhas BW, Packiasabapathy S, et al. A novel perioperative multidose methadone-based multimodal analgesic strategy in children achieved safe and low analgesic blood methadone levels enabling opioid-sparing sustained analgesia with minimal adverse effects. Anesth Analg. 2021;133:327–37. A novel study that examined low-dose scheduled methadone and analyzed opioid consumption and plasma methadone levels for spinal fusion and pectus excavatum surgery.PubMedPubMedCentralCrossRef
28.
Zurück zum Zitat Gottschalk A, Durieux ME, Nemergut EC. Intraoperative methadone improves postoperative pain control in patients undergoing complex spine surgery. Anesth Analg. 2011;112(1):218–23.PubMedCrossRef Gottschalk A, Durieux ME, Nemergut EC. Intraoperative methadone improves postoperative pain control in patients undergoing complex spine surgery. Anesth Analg. 2011;112(1):218–23.PubMedCrossRef
29.
Zurück zum Zitat Martin DP, Samora WP 3rd, Beebe AC, et al. Analgesic effects of methadone and magnesium following posterior spinal fusion for idiopathic scoliosis in adolescents: a randomized controlled trial. J Anesth. 2018;32(5):702–8.PubMedCrossRef Martin DP, Samora WP 3rd, Beebe AC, et al. Analgesic effects of methadone and magnesium following posterior spinal fusion for idiopathic scoliosis in adolescents: a randomized controlled trial. J Anesth. 2018;32(5):702–8.PubMedCrossRef
30.•
Zurück zum Zitat Ye J, Myung K, Packiasabapathy S, et al. Methadone-based multimodal analgesia provides the best-in-class acute surgical pain control and functional outcomes with lower opioid use following major posterior fusion surgery in adolescents with idiopathic scoliosis. Pediatr Wal Saf. 2020;5(4): e336. A study that examined a methadone protocol that showed significant reductions in length of stay, opioid consumption, and other secondary outcomes. Ye J, Myung K, Packiasabapathy S, et al. Methadone-based multimodal analgesia provides the best-in-class acute surgical pain control and functional outcomes with lower opioid use following major posterior fusion surgery in adolescents with idiopathic scoliosis. Pediatr Wal Saf. 2020;5(4): e336. A study that examined a methadone protocol that showed significant reductions in length of stay, opioid consumption, and other secondary outcomes.
31.
Zurück zum Zitat Norris JV, Don HF. Prolonged depression of respiratory rate following methadone analgesia. Anesthesiology. 1976;45(3):361–2.PubMedCrossRef Norris JV, Don HF. Prolonged depression of respiratory rate following methadone analgesia. Anesthesiology. 1976;45(3):361–2.PubMedCrossRef
32.•
Zurück zum Zitat Murphy GS, Avram MJ, Greenberg SB, et al. Perioperative methadone and ketamine for postoperative pain control in spine surgical patients. Anesthesiology. 2021;134(5):697–708. A randomized, double blinded, placebo-controlled study that shows that the addition of ketamine with methadone may have an additive effect in reducing opioid requirements compared to methadone alone.PubMedCrossRef Murphy GS, Avram MJ, Greenberg SB, et al. Perioperative methadone and ketamine for postoperative pain control in spine surgical patients. Anesthesiology. 2021;134(5):697–708. A randomized, double blinded, placebo-controlled study that shows that the addition of ketamine with methadone may have an additive effect in reducing opioid requirements compared to methadone alone.PubMedCrossRef
33.••
Zurück zum Zitat Kars MS, Villacres Mori B, Ahn S, et al. Fentanyl versus remifentanil-based TIVA for pediatric scoliosis repair: does it matter? Reg Anesth Pain Med. 2019;44(6):627–31. A retrospective study comparing intraoperative fentanyl versus remifentanil and postoperative opioid consumption.PubMedCrossRef Kars MS, Villacres Mori B, Ahn S, et al. Fentanyl versus remifentanil-based TIVA for pediatric scoliosis repair: does it matter? Reg Anesth Pain Med. 2019;44(6):627–31. A retrospective study comparing intraoperative fentanyl versus remifentanil and postoperative opioid consumption.PubMedCrossRef
34.
Zurück zum Zitat Fletcher D, Martinez V. Opioid-induced hyperalgesia in patients after surgery: a systematic review and meta-analysis. Br J Anaesth. 2014;112(6):991–1004.PubMedCrossRef Fletcher D, Martinez V. Opioid-induced hyperalgesia in patients after surgery: a systematic review and meta-analysis. Br J Anaesth. 2014;112(6):991–1004.PubMedCrossRef
35.
Zurück zum Zitat Kim SH, Stoicea N, Soghomonyan S, et al. Intraoperative use of remifentanil and opioid induced hyperalgiesa/acute opioid tolerance: systematic review. Front Pharmacol. 2014;8(5):108. Kim SH, Stoicea N, Soghomonyan S, et al. Intraoperative use of remifentanil and opioid induced hyperalgiesa/acute opioid tolerance: systematic review. Front Pharmacol. 2014;8(5):108.
36.••
Zurück zum Zitat Santonocito C, Noto A, Crimi C, et al. Remifentanil-induced postoperative hyperalgesia: current perspectives on mechanisms and therapeutic strategies. Local Reg Anesth. 2018;9(11):15–23. Review of mechanism and management strategies of opioid-induced hyperalgesia.CrossRef Santonocito C, Noto A, Crimi C, et al. Remifentanil-induced postoperative hyperalgesia: current perspectives on mechanisms and therapeutic strategies. Local Reg Anesth. 2018;9(11):15–23. Review of mechanism and management strategies of opioid-induced hyperalgesia.CrossRef
37.
Zurück zum Zitat Muhly WT, Sankar WN, Ryan K, et al. Rapid recovery pathway after spinal fusion for idiopathic scoliosis. Pediatrics. 2016;137(4):e20151568.PubMedCrossRef Muhly WT, Sankar WN, Ryan K, et al. Rapid recovery pathway after spinal fusion for idiopathic scoliosis. Pediatrics. 2016;137(4):e20151568.PubMedCrossRef
38.
Zurück zum Zitat Monitto CL, Hsu A, Gao S, et al. Opioid prescribing for the treatment of acute pain in children on hospital discharge. Anesth Analg. 2017;125(6):2113–22.PubMedPubMedCentralCrossRef Monitto CL, Hsu A, Gao S, et al. Opioid prescribing for the treatment of acute pain in children on hospital discharge. Anesth Analg. 2017;125(6):2113–22.PubMedPubMedCentralCrossRef
39.
Zurück zum Zitat Feinberb AE, Chesney TR, Srikandarajah S, et al. Opioid use after discharge in postoperative patients: a systematic review. Ann Surg. 2018;267(6):1056–62.CrossRef Feinberb AE, Chesney TR, Srikandarajah S, et al. Opioid use after discharge in postoperative patients: a systematic review. Ann Surg. 2018;267(6):1056–62.CrossRef
40.
Zurück zum Zitat Goodarzi M. The advantages of intrathecal opioids for spinal fusion in children. Paediatr Anaesth. 1998;8(2):131–4.PubMedCrossRef Goodarzi M. The advantages of intrathecal opioids for spinal fusion in children. Paediatr Anaesth. 1998;8(2):131–4.PubMedCrossRef
41.
Zurück zum Zitat Gall O, Aubineau JV, Berniere J, et al. Analgesic effect of low-dose intrathecal morphine after spinal fusion in children. Anesthesiology. 2001;94(3):447–52.PubMedCrossRef Gall O, Aubineau JV, Berniere J, et al. Analgesic effect of low-dose intrathecal morphine after spinal fusion in children. Anesthesiology. 2001;94(3):447–52.PubMedCrossRef
42.
Zurück zum Zitat Eschertzhuber S, Hohlrieder M, Keller C, et al. Comparison of high and low dose intrathecal morphine for spinal fusion in children. Br J Anaesth. 2008;100(4):538–43.PubMedCrossRef Eschertzhuber S, Hohlrieder M, Keller C, et al. Comparison of high and low dose intrathecal morphine for spinal fusion in children. Br J Anaesth. 2008;100(4):538–43.PubMedCrossRef
43.
Zurück zum Zitat Tripi PA, Poe-Kochert C, Potzman J, et al. Intrathecal morphine for postoperative analgesia in patients with idiopathic scoliosis undergoing posterior spinal fusion. Spine (Phila Pa 1976). 2008;33(20):2248–51.PubMedCrossRef Tripi PA, Poe-Kochert C, Potzman J, et al. Intrathecal morphine for postoperative analgesia in patients with idiopathic scoliosis undergoing posterior spinal fusion. Spine (Phila Pa 1976). 2008;33(20):2248–51.PubMedCrossRef
44.
Zurück zum Zitat Ganesh A, Kim A, Casale P, et al. Low-dose intrathecal morphine for postoperative analgesia in children. Anesth Analg. 2007;104(2):271–6.PubMedCrossRef Ganesh A, Kim A, Casale P, et al. Low-dose intrathecal morphine for postoperative analgesia in children. Anesth Analg. 2007;104(2):271–6.PubMedCrossRef
45.
Zurück zum Zitat Pieters BJ, Anderson JT, Price N, et al. Low-dose versus high-dose postoperative naloxone infusion combined with patient-controlled analgesia for adolescent idiopathic scoliosis surgery: A randomized controlled trial. Spine Deform. 2018;6(4):430–4.PubMedCrossRef Pieters BJ, Anderson JT, Price N, et al. Low-dose versus high-dose postoperative naloxone infusion combined with patient-controlled analgesia for adolescent idiopathic scoliosis surgery: A randomized controlled trial. Spine Deform. 2018;6(4):430–4.PubMedCrossRef
46.
Zurück zum Zitat Cohen M, Zuk J, McKay N, et al. Intrathecal morphine versus extended-release epidural morphine for postoperative pain control in pediatric patients undergoing posterior spinal fusion. Anesth Analg. 2017;124(6):2030–7.PubMedPubMedCentralCrossRef Cohen M, Zuk J, McKay N, et al. Intrathecal morphine versus extended-release epidural morphine for postoperative pain control in pediatric patients undergoing posterior spinal fusion. Anesth Analg. 2017;124(6):2030–7.PubMedPubMedCentralCrossRef
47.
Zurück zum Zitat Milbrandt TA, Singhal M, Minter C, et al. A comparison of three methods of pain control for posterior spinal fusions in adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2009;34(14):1499–503.PubMedCrossRef Milbrandt TA, Singhal M, Minter C, et al. A comparison of three methods of pain control for posterior spinal fusions in adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2009;34(14):1499–503.PubMedCrossRef
48.
Zurück zum Zitat Sucato DJ, Duey-Holtz A, Elerson E, et al. Postoperative analgesia following surgical correction for adolescent idiopathic scoliosis: a comparison of continuous epidural analgesia and patient-controlled analgesia. Spine (Phila Pa 1976). 2005;30(2):211–7.PubMedCrossRef Sucato DJ, Duey-Holtz A, Elerson E, et al. Postoperative analgesia following surgical correction for adolescent idiopathic scoliosis: a comparison of continuous epidural analgesia and patient-controlled analgesia. Spine (Phila Pa 1976). 2005;30(2):211–7.PubMedCrossRef
49.
Zurück zum Zitat Bertolini A, Ferrari A, Ottani A, et al. Paracetamol: new vistas of an old drug. CNS Drug Rev. 2006;12(3–4):250–75.PubMedCrossRef Bertolini A, Ferrari A, Ottani A, et al. Paracetamol: new vistas of an old drug. CNS Drug Rev. 2006;12(3–4):250–75.PubMedCrossRef
50.
Zurück zum Zitat Anderson BJ. Paracetamol (acetaminophen): mechanisms of action. Paediatr Anaesth. 2008;18(10):915–21.PubMedCrossRef Anderson BJ. Paracetamol (acetaminophen): mechanisms of action. Paediatr Anaesth. 2008;18(10):915–21.PubMedCrossRef
51.
Zurück zum Zitat Ferreira SH, Lorenzetti BB, Correa FM. Central and peripheral antialgesic action of aspirin-like drugs. Eur J Pharmacol. 1978;53(1):39–48.PubMedCrossRef Ferreira SH, Lorenzetti BB, Correa FM. Central and peripheral antialgesic action of aspirin-like drugs. Eur J Pharmacol. 1978;53(1):39–48.PubMedCrossRef
52.
Zurück zum Zitat Wong I, St. John-Green C, Walker SM. Opioid-sparing effects of perioperative paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) in children. Paediatr Anaesth. 2013;23(6):475–95.PubMedPubMedCentralCrossRef Wong I, St. John-Green C, Walker SM. Opioid-sparing effects of perioperative paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) in children. Paediatr Anaesth. 2013;23(6):475–95.PubMedPubMedCentralCrossRef
53.
Zurück zum Zitat Rizkalla N, Zane NR, Prodell JL, et al. Use of intravenous acetaminophen in children for analgesia after spinal fusion surgery: a randomized clinical trial. J Pediatr Pharmacol Ther. 2018;23(5):395–404.PubMedPubMedCentral Rizkalla N, Zane NR, Prodell JL, et al. Use of intravenous acetaminophen in children for analgesia after spinal fusion surgery: a randomized clinical trial. J Pediatr Pharmacol Ther. 2018;23(5):395–404.PubMedPubMedCentral
54.
Zurück zum Zitat Olbrecht VA, Ding L, Spruance K, et al. Intravenous acetaminophen reduces length of stay via mediation of postoperative opioid consumption after posterior spinal fusion in a pediatric cohort. Clin J Pain. 2018;34(7):593–9.PubMedPubMedCentralCrossRef Olbrecht VA, Ding L, Spruance K, et al. Intravenous acetaminophen reduces length of stay via mediation of postoperative opioid consumption after posterior spinal fusion in a pediatric cohort. Clin J Pain. 2018;34(7):593–9.PubMedPubMedCentralCrossRef
55.••
Zurück zum Zitat Lammers CR, Schwinghammer AJ, Hall B, Kriss RS, Aizenberg DA, Funamura JL, Senders CW, Nittur V, Applegate RL 2nd. Comparison of oral loading dose to intravenous acetaminophen in children for analgesia after tonsillectomy and adenoidectomy: a randomized clinical trial. Anesth Analg. 2021;133:1568–76. Comparison of analgesic effects of oral acetaminophen versus intravenous acetaminophen.PubMedCrossRef Lammers CR, Schwinghammer AJ, Hall B, Kriss RS, Aizenberg DA, Funamura JL, Senders CW, Nittur V, Applegate RL 2nd. Comparison of oral loading dose to intravenous acetaminophen in children for analgesia after tonsillectomy and adenoidectomy: a randomized clinical trial. Anesth Analg. 2021;133:1568–76. Comparison of analgesic effects of oral acetaminophen versus intravenous acetaminophen.PubMedCrossRef
56.
Zurück zum Zitat Malmberg AB, Yaksh TL. Hyperalgesia mediatred by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science. 1992;257(5074):1276–9.PubMedCrossRef Malmberg AB, Yaksh TL. Hyperalgesia mediatred by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science. 1992;257(5074):1276–9.PubMedCrossRef
57.
Zurück zum Zitat Michelet D, Andreau-Gallien J, Bensalah T, et al. A meta-analysis of the use of nonsteroidal anti-inflammatory drugs for pediatric postoperative pain. Anesthe Analg. 2012;114(2):393–406.CrossRef Michelet D, Andreau-Gallien J, Bensalah T, et al. A meta-analysis of the use of nonsteroidal anti-inflammatory drugs for pediatric postoperative pain. Anesthe Analg. 2012;114(2):393–406.CrossRef
58.
Zurück zum Zitat Hannam J, Anderson BJ. Explaining the acetaminophen-ibuprofen analgesic interaction using a response surface model. Paediatr Anaesth. 2011;21(12):1234–40.PubMedCrossRef Hannam J, Anderson BJ. Explaining the acetaminophen-ibuprofen analgesic interaction using a response surface model. Paediatr Anaesth. 2011;21(12):1234–40.PubMedCrossRef
59.
Zurück zum Zitat Rosenberg RE, Trzcinski S, Cohen M, et al. The association between adjuvant pain medication use and outcomes following pediatric spinal fusion. Spine (Phila Pa 1976). 2017;42(10):E602–8. Rosenberg RE, Trzcinski S, Cohen M, et al. The association between adjuvant pain medication use and outcomes following pediatric spinal fusion. Spine (Phila Pa 1976). 2017;42(10):E602–8.
60.
Zurück zum Zitat Duttchen KM, Lo A, Walker A, et al. Intraoperative ketorolac dose of 15mg versus the standard 30 mg on early postoperative pain after spine surgery: a randomized, blinded, non-inferiority trial. J Clin Anesth. 2017;41:11–5.PubMedCrossRef Duttchen KM, Lo A, Walker A, et al. Intraoperative ketorolac dose of 15mg versus the standard 30 mg on early postoperative pain after spine surgery: a randomized, blinded, non-inferiority trial. J Clin Anesth. 2017;41:11–5.PubMedCrossRef
61.
Zurück zum Zitat Long J, Lewis S, Kuklo T, et al. The effect of cyclooxygenase-2 inhibitors on spinal fusion. J Bone Joint Surg Am. 2002;84(10):1763–8.PubMedCrossRef Long J, Lewis S, Kuklo T, et al. The effect of cyclooxygenase-2 inhibitors on spinal fusion. J Bone Joint Surg Am. 2002;84(10):1763–8.PubMedCrossRef
62.
Zurück zum Zitat Reuben SS, Ablett D, Kaye R. High dose nonsteroidal anti-inflammatory drugs compromise spinal fusion. Can J Anaesth. 2005;52(5):506–12.PubMedCrossRef Reuben SS, Ablett D, Kaye R. High dose nonsteroidal anti-inflammatory drugs compromise spinal fusion. Can J Anaesth. 2005;52(5):506–12.PubMedCrossRef
63.
Zurück zum Zitat Sucato DJ, Lovejoy JF, Agrawal S, et al. Postoperative ketorolac does not predispose to pseudoarthrosis following posterior spinal fusion and instrumentation for adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2008;33(10):1119–24.PubMedCrossRef Sucato DJ, Lovejoy JF, Agrawal S, et al. Postoperative ketorolac does not predispose to pseudoarthrosis following posterior spinal fusion and instrumentation for adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2008;33(10):1119–24.PubMedCrossRef
64.
Zurück zum Zitat Vitale MG, Choe JC, Hwang MW, et al. Use of ketorolac tromethamine in children undergoing scoliosis surgery. An analysis of complications. Spine J. 2003;3(1):55–62.PubMedCrossRef Vitale MG, Choe JC, Hwang MW, et al. Use of ketorolac tromethamine in children undergoing scoliosis surgery. An analysis of complications. Spine J. 2003;3(1):55–62.PubMedCrossRef
65.
Zurück zum Zitat Maslin B, Lipana L, Roth B, et al. Safety considerations in the use of ketorolac for postoperative pain. Curr Drug Saf. 2017;12(1):67–73.PubMedCrossRef Maslin B, Lipana L, Roth B, et al. Safety considerations in the use of ketorolac for postoperative pain. Curr Drug Saf. 2017;12(1):67–73.PubMedCrossRef
66.
Zurück zum Zitat Rusy LM, Hainsworth KR, Nelson TJ, et al. Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesth Analg. 2010;110(5):1393–8.PubMedCrossRef Rusy LM, Hainsworth KR, Nelson TJ, et al. Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesth Analg. 2010;110(5):1393–8.PubMedCrossRef
67.
Zurück zum Zitat Mayell A, Srinivasan I, Campbell F, et al. Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. Paediatr Anaesth. 2014;24(12):1239–44.PubMedCrossRef Mayell A, Srinivasan I, Campbell F, et al. Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. Paediatr Anaesth. 2014;24(12):1239–44.PubMedCrossRef
68.•
Zurück zum Zitat Li Y, Swallow J, Robbins C, et al. Gabapentin and intrathecal morphine combination therapy results in decreased oral narcotic use and more consistent pain scores after posterior spinal fusion for adolescent idiopathic scoliosis. J Orthop Surg Res. 2021;16(1):672. Examination of addition of gabapentin to analgesic protocol with intrathecal morphine.PubMedPubMedCentralCrossRef Li Y, Swallow J, Robbins C, et al. Gabapentin and intrathecal morphine combination therapy results in decreased oral narcotic use and more consistent pain scores after posterior spinal fusion for adolescent idiopathic scoliosis. J Orthop Surg Res. 2021;16(1):672. Examination of addition of gabapentin to analgesic protocol with intrathecal morphine.PubMedPubMedCentralCrossRef
69.•
70.••
Zurück zum Zitat Egunsola O, Wylie CE, Chitty KM, Buckley NA. Systematic review of the efficacy and safety of gabapentin and pregabalin for pain in children and adolescents. Anesth Analg. 2019;128:811–9. Large-scale examination of gabapentenoid use for acute pain in pediatric patients.PubMedCrossRef Egunsola O, Wylie CE, Chitty KM, Buckley NA. Systematic review of the efficacy and safety of gabapentin and pregabalin for pain in children and adolescents. Anesth Analg. 2019;128:811–9. Large-scale examination of gabapentenoid use for acute pain in pediatric patients.PubMedCrossRef
71.
Zurück zum Zitat Desai PH, Taylor O, Shah KJ, Evoy KE, Peckham AM. Characterization of hospitalized patients who received naloxone while receiving opioids with or without gabapentinoids. Ment Health Clin. 2021;11:225–30.PubMedPubMedCentralCrossRef Desai PH, Taylor O, Shah KJ, Evoy KE, Peckham AM. Characterization of hospitalized patients who received naloxone while receiving opioids with or without gabapentinoids. Ment Health Clin. 2021;11:225–30.PubMedPubMedCentralCrossRef
72.
Zurück zum Zitat Moustafa AM, Negmi HH, Rabie ME. The combined effect of ketamine and remifentanil infusions as total intravenous anesthesia for scoliosis surgery in children. Middle East J Anaesthesiol. 2008;19(5):1151-68. 125 (Perelló M, Artés D, Pasc).PubMed Moustafa AM, Negmi HH, Rabie ME. The combined effect of ketamine and remifentanil infusions as total intravenous anesthesia for scoliosis surgery in children. Middle East J Anaesthesiol. 2008;19(5):1151-68. 125 (Perelló M, Artés D, Pasc).PubMed
73.
Zurück zum Zitat Schwenk EA, Viscusi ER, Buvanendran A, et al. Consensus guidelines on the use of intravenous ketamine infusions for acute pain management from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists. Reg Anesth Pain Med. 2018;43(5):456–66.PubMedPubMedCentral Schwenk EA, Viscusi ER, Buvanendran A, et al. Consensus guidelines on the use of intravenous ketamine infusions for acute pain management from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists. Reg Anesth Pain Med. 2018;43(5):456–66.PubMedPubMedCentral
76.•
Zurück zum Zitat Haratian A, Musa A, Field R, et al. Intravenous lidocaine in spine surgery: a meta-analysis of randomized controlled trials. N Am Spine Soc J. 2021;7:100079. Published 2021 Sep 6. https://doi.org/10.1016/j.xnsj.2021.100079. An analysis of available data regarding systemic lidocaine use and perioperative pain after spine surgery. Haratian A, Musa A, Field R, et al. Intravenous lidocaine in spine surgery: a meta-analysis of randomized controlled trials. N Am Spine Soc J. 2021;7:100079. Published 2021 Sep 6. https://​doi.​org/​10.​1016/​j.​xnsj.​2021.​100079. An analysis of available data regarding systemic lidocaine use and perioperative pain after spine surgery.
78.
Zurück zum Zitat Dewinter G, Moens P, Fieuws S, Vanaudenaerde B, Van de Velde M, Rex S. Systemic lidocaine fails to improve postoperative morphine consumption, postoperative recovery and quality of life in patients undergoing posterior spinal arthrodesis. A double-blind, randomized, placebo-controlled trial. Br J Anaesth. 2017;118(4):576–85. https://doi.org/10.1093/bja/aex038.CrossRefPubMed Dewinter G, Moens P, Fieuws S, Vanaudenaerde B, Van de Velde M, Rex S. Systemic lidocaine fails to improve postoperative morphine consumption, postoperative recovery and quality of life in patients undergoing posterior spinal arthrodesis. A double-blind, randomized, placebo-controlled trial. Br J Anaesth. 2017;118(4):576–85. https://​doi.​org/​10.​1093/​bja/​aex038.CrossRefPubMed
80.
Zurück zum Zitat Cater DT, Rogerson CM, Hobson MJ, et al. The association of postoperative dexmedetomidine with pain, opiate utilization, and hospital length of stay in children post-chiari malformation decompression. J Neurosurg Pediatr. 2021;10:1–7. Cater DT, Rogerson CM, Hobson MJ, et al. The association of postoperative dexmedetomidine with pain, opiate utilization, and hospital length of stay in children post-chiari malformation decompression. J Neurosurg Pediatr. 2021;10:1–7.
81.
Zurück zum Zitat Jones JS, Cotugno RE, Singhal NR, et al. Evaluation of dexmedetomidine and postoperative pain management in patients with adolescent idiopathic scoliosis: conclusions based on a retrospective study at a tertiary pediatric hospital. Pediatr Crit Care Med. 2014;15(6):e247–52.PubMedCrossRef Jones JS, Cotugno RE, Singhal NR, et al. Evaluation of dexmedetomidine and postoperative pain management in patients with adolescent idiopathic scoliosis: conclusions based on a retrospective study at a tertiary pediatric hospital. Pediatr Crit Care Med. 2014;15(6):e247–52.PubMedCrossRef
82.
Zurück zum Zitat Sadhasivam S, Boat A, Mahmoud M. Comparison of patient-controlled analgesia with and without dexmedetomidine following spine surgery in children. J Clin Anesth. 2009;21(7):493–501.PubMedCrossRef Sadhasivam S, Boat A, Mahmoud M. Comparison of patient-controlled analgesia with and without dexmedetomidine following spine surgery in children. J Clin Anesth. 2009;21(7):493–501.PubMedCrossRef
83.
Zurück zum Zitat Holt F, Strantzas S, Zaarour C, et al. The effect of dexmedetomidine on montor-evoked potentials during pediatric posterior spinal fusion surgery: a retrospective case-control study. Can J Anaesth. 2020;67(10):1341–8.PubMedCrossRef Holt F, Strantzas S, Zaarour C, et al. The effect of dexmedetomidine on montor-evoked potentials during pediatric posterior spinal fusion surgery: a retrospective case-control study. Can J Anaesth. 2020;67(10):1341–8.PubMedCrossRef
84.
Zurück zum Zitat Vink R, Mechifor M. Magnesium in the central nervous system. Adelaide (AU): University of Adelaide Press; 2011.CrossRef Vink R, Mechifor M. Magnesium in the central nervous system. Adelaide (AU): University of Adelaide Press; 2011.CrossRef
85.
Zurück zum Zitat Martin DP, Samora WP, Beebe AC, et al. Analgesic effects of methadone and magnesium following posterior spinal fusion for idiopathic scoliosis in adolescents: a randomized controlled trial. J Anesth. 2018;32(5):702–8.PubMedCrossRef Martin DP, Samora WP, Beebe AC, et al. Analgesic effects of methadone and magnesium following posterior spinal fusion for idiopathic scoliosis in adolescents: a randomized controlled trial. J Anesth. 2018;32(5):702–8.PubMedCrossRef
86.•
Zurück zum Zitat Ng KT, Yap JL, Izham IN, et al. The effect of intravenous magnesium on postoperative morphine consumption in noncardiac surgery: a systematic review and meta-analysis with trial sequential analysis. Eur J Anaesthesiol. 2020;37:212–23. Large-scale review of magnesium as an acute pain agent within the perioperative period.PubMedCrossRef Ng KT, Yap JL, Izham IN, et al. The effect of intravenous magnesium on postoperative morphine consumption in noncardiac surgery: a systematic review and meta-analysis with trial sequential analysis. Eur J Anaesthesiol. 2020;37:212–23. Large-scale review of magnesium as an acute pain agent within the perioperative period.PubMedCrossRef
87.••
Zurück zum Zitat Fletcher ND, Ruska T, Austin TM, Guisse NF, Murphy JS, Bruce RW Jr. Postoperative dexamethasone following posterior spinal fusion for adolescent idiopathic scoliosis. J Bone Joint Surg Am. 2020;102(20):1807–13. Examination of analgesic effects of novel perioperative dexamethasone protocol for spinal fusion surgery.PubMedCrossRef Fletcher ND, Ruska T, Austin TM, Guisse NF, Murphy JS, Bruce RW Jr. Postoperative dexamethasone following posterior spinal fusion for adolescent idiopathic scoliosis. J Bone Joint Surg Am. 2020;102(20):1807–13. Examination of analgesic effects of novel perioperative dexamethasone protocol for spinal fusion surgery.PubMedCrossRef
88.
Zurück zum Zitat Erdogan MA, Ozgul U, Ucar M, et al. Patient-controlled intermittent epidural bolus versus epidural infusion for posterior spinal fusion after adolescent idiopathic scoliosis: prospective, randomized, double-blinded study. Spine (Phila PA 1976). 2017;42(12):882–6.PubMedCrossRef Erdogan MA, Ozgul U, Ucar M, et al. Patient-controlled intermittent epidural bolus versus epidural infusion for posterior spinal fusion after adolescent idiopathic scoliosis: prospective, randomized, double-blinded study. Spine (Phila PA 1976). 2017;42(12):882–6.PubMedCrossRef
89.
Zurück zum Zitat Lavelle ED, Lavelle W, Goodwin R, et al. Epidural analgesia for postoperative pain control after adolescent spinal fusion procedures which violated the epidural space. J Spinal Disord Tech. 2010;23(5):347–50.PubMedCrossRef Lavelle ED, Lavelle W, Goodwin R, et al. Epidural analgesia for postoperative pain control after adolescent spinal fusion procedures which violated the epidural space. J Spinal Disord Tech. 2010;23(5):347–50.PubMedCrossRef
90.
Zurück zum Zitat Ravish M, Muldowney B, Becker A, et al. Pain management in patients with adolescent idiopathic scoliosis undergoing posterior spinal fusion: combined intrathecal morphine and continuous epidural versus PCA. J Pediatr Orthop. 2012;32(8):799–804.PubMedCrossRef Ravish M, Muldowney B, Becker A, et al. Pain management in patients with adolescent idiopathic scoliosis undergoing posterior spinal fusion: combined intrathecal morphine and continuous epidural versus PCA. J Pediatr Orthop. 2012;32(8):799–804.PubMedCrossRef
91.••
Zurück zum Zitat Guay J, Suresh S, Kopp S, et al. Postoperative epidural analgesia versus systemic analgesia for thoraco-lumbar spine surgery in children. Cochrane Database Syst Rev. 2019;1(1):CD012819. Cochrane review examining available evidence that compares epidural analgesia versus systemic analgesic protocols for spine surgery in pediatric patients.PubMed Guay J, Suresh S, Kopp S, et al. Postoperative epidural analgesia versus systemic analgesia for thoraco-lumbar spine surgery in children. Cochrane Database Syst Rev. 2019;1(1):CD012819. Cochrane review examining available evidence that compares epidural analgesia versus systemic analgesic protocols for spine surgery in pediatric patients.PubMed
92.
Zurück zum Zitat Klatt JW, Mickelson J, Hung M, et al. A randomized prospective evaluation of 3 techniques of postoperative pain management after posterior spinal instrumentation and fusion. Spine (Phila Pa 1976). 2013;38(19):1626–31.PubMedCrossRef Klatt JW, Mickelson J, Hung M, et al. A randomized prospective evaluation of 3 techniques of postoperative pain management after posterior spinal instrumentation and fusion. Spine (Phila Pa 1976). 2013;38(19):1626–31.PubMedCrossRef
94.
Zurück zum Zitat Xiao X, Zhu T, Wang L, et al. Efficacy of postoperative analgesia by erector spinal plane block after lumber surgery: a systematic review and meta-analysis of randomized controlled trials. Comput Math Methods Med. 2022;2022:3264142.PubMedPubMedCentralCrossRef Xiao X, Zhu T, Wang L, et al. Efficacy of postoperative analgesia by erector spinal plane block after lumber surgery: a systematic review and meta-analysis of randomized controlled trials. Comput Math Methods Med. 2022;2022:3264142.PubMedPubMedCentralCrossRef
95.
Zurück zum Zitat Soffin EM, Okano I, Oezel L, et al. Impact of ultrasound-guided erector spinae plane block on outcomes after lumbar spinal fusion: a retrospective propensity score matched study of 242 patients. Reg Anesth Pain Med. 2022;47(2):79–86.PubMedCrossRef Soffin EM, Okano I, Oezel L, et al. Impact of ultrasound-guided erector spinae plane block on outcomes after lumbar spinal fusion: a retrospective propensity score matched study of 242 patients. Reg Anesth Pain Med. 2022;47(2):79–86.PubMedCrossRef
96.
Zurück zum Zitat Stondell C, Roberto R. Erector spinae plane blocks with liposomal bupivacaine for pediatric scoliosis surgery. J Am Acad Orthop Sug Glob Res Rev. 2022;6(1):e21.00272. Stondell C, Roberto R. Erector spinae plane blocks with liposomal bupivacaine for pediatric scoliosis surgery. J Am Acad Orthop Sug Glob Res Rev. 2022;6(1):e21.00272.
97.
Zurück zum Zitat Hussain N, Brull R, Sheehy B, et al. Perinerual liposomal bupivacaine is not superior to nonliposomal bupivacaine for peripheral nerve block analgesia. Anesthesiology. 2021;134(2):147–64.PubMedCrossRef Hussain N, Brull R, Sheehy B, et al. Perinerual liposomal bupivacaine is not superior to nonliposomal bupivacaine for peripheral nerve block analgesia. Anesthesiology. 2021;134(2):147–64.PubMedCrossRef
98.
Zurück zum Zitat Cloyd C, Moffett BS, Bernhardt MB, et al. Efficacy of liposomal bupivacaine in pediatric patients undergoing spine surgery. Paediatr Anaesth. 2018;28(11):982–6.PubMedCrossRef Cloyd C, Moffett BS, Bernhardt MB, et al. Efficacy of liposomal bupivacaine in pediatric patients undergoing spine surgery. Paediatr Anaesth. 2018;28(11):982–6.PubMedCrossRef
99.
Zurück zum Zitat Reynolds RAK, Legakis JE, Tweedie J, et al. Postoperative pain management after spinal fusion surgery: an analysis of the efficacy of continuous infusion of local anesthetics. Glob Spine J. 2013;3(1):7–13.CrossRef Reynolds RAK, Legakis JE, Tweedie J, et al. Postoperative pain management after spinal fusion surgery: an analysis of the efficacy of continuous infusion of local anesthetics. Glob Spine J. 2013;3(1):7–13.CrossRef
Metadaten
Titel
Perioperative Pain Management After Posterior Spinal Fusion for Idiopathic Scoliosis
verfasst von
McKenzee Murdock
Jared R. E. Hylton
Publikationsdatum
26.09.2023
Verlag
Springer US
Erschienen in
Current Anesthesiology Reports / Ausgabe 4/2023
Elektronische ISSN: 2167-6275
DOI
https://doi.org/10.1007/s40140-023-00578-w

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