Erschienen in:
11.01.2023 | Correspondence
Pilot study of the prevalence of autoimmune disorders in Li-Fraumeni syndrome
verfasst von:
Ixtaccihuatl H. Obregón, Kelvin C. de Andrade, Renee C. Bremer, Payal P. Khincha, Sharon A. Savage
Erschienen in:
Familial Cancer
|
Ausgabe 3/2023
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Excerpt
Li-Fraumeni syndrome (LFS) is an inherited cancer predisposition syndrome primarily caused by heterozygous pathogenic or likely pathogenic (P/LP) germline
TP53 variants
. Individuals with LFS have a 24-fold increased risk of cancer compared with the general population [
1]. A growing number of clinical anecdotes, patient inquiries, and interest in TP53’s role in tumor immune surveillance [
2] prompted us to conduct a pilot study of the prevalence of autoimmune disorders in individuals with LFS. …