Erschienen in:
01.05.2004 | Brief Report
Plasma interleukin-6 levels in Mediterranean spotted fever
verfasst von:
J. Oristrell, M. Sampere, M. J. Amengual, B. Font, F. Segura
Erschienen in:
European Journal of Clinical Microbiology & Infectious Diseases
|
Ausgabe 5/2004
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Excerpt
Mediterranean spotted fever (MSF) is a rickettsiosis endemic to Mediterranean countries caused by
Rickettsia conorii, an obligate intracellular bacterium with endothelial cell tropism [
1]. In a previous study we found an association between high plasma levels of tumor necrosis factor alpha (TNF-α) and severe MSF, raising the question of whether TNF-α is a causal contributor to disease pathogenesis or whether it is a nonspecific epiphenomenon [
2]. In order to better characterize the role of proinflammatory cytokines in the pathogenesis of MSF we conducted the present study in which the plasma levels of interleukin-6 (IL-6) were analyzed and the variables significantly associated with disease severity were examined. …