Erschienen in:
22.06.2020 | Hepatitis B (JK Lim, Section Editor)
Point of Care Diagnostic Testing for Hepatitis B Virus
verfasst von:
Kathy Jackson, Robert G. Gish
Erschienen in:
Current Hepatology Reports
|
Ausgabe 3/2020
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Abstract
Purpose of Review
As we strive to reach the World Health Organization (WHO) goal of eliminating viral hepatitis as a public health threat by 2030, point of care tests (POCTs) will be important in low- to middle-income and developed countries. This review aims to investigate available POCT choices for hepatitis B virus (HBV) and to provide an algorithm for screening, assessing, and monitoring chronic HBV.
Recent Findings
There are 3 WHO pre-qualified rapid diagnostic assays for hepatitis B surface antigen (HBsAg) that are sensitive, specific, and reliable in screening for HBV: SD Bioline, Determine 2, and VIKIA. POCTs for other biomarkers are less reliable and sensitive but have some applicability. The Xpert® HBV Viral Load assay is sensitive and specific with a wide dynamic range.
Summary
While POCT for HBeAg and HBV antibodies require improvement, HBsAg POCT and the Xpert® HBV Viral Load assay are reliable and available now.