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01.10.2014 | Chest

Portopulmonary hypertension: Improved detection using CT and echocardiography in combination

verfasst von: Anand Devaraj, Robert Loveridge, Diana Bosanac, Konstantinos Stefanidis, William Bernal, Christopher Willars, Julia A. Wendon, Georg Auzinger, Sujal R. Desai

Erschienen in: European Radiology | Ausgabe 10/2014

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Abstract

Objectives

To establish the relationship between CT signs of pulmonary hypertension and mean pulmonary artery pressure (mPAP) in patients with liver disease, and to determine the additive value of CT in the detection of portopulmonary hypertension in combination with transthoracic echocardiography.

Methods

Forty-nine patients referred for liver transplantation were retrospectively reviewed. Measured CT signs included the main pulmonary artery/ascending aorta diameter ratio (PA/AA_meas) and the mean left and right main PA diameter (RLPA_meas). Enlargement of the pulmonary artery compared to the ascending aorta was also assessed visually (PA/AA_vis). CT measurements were correlated with right-sided heart catheter-derived mPAP. The ability of PA/AA_vis combined with echocardiogram-derived right ventricular systolic pressure (RVSP) to detect portopulmonary hypertension was tested with ROC analysis.

Results

There were moderate correlations between mPAP and both PA/AA_meas and RLPA_meas (r_s = 0.41 and r_s = 0.42, respectively; p < 0.005). Compared to transthoracic echocardiography alone (AUC = 0.59, p = 0.23), a diagnostic algorithm incorporating PA/AA_vis and transthoracic echocardiography-derived RVSP improved the detection of portopulmonary hypertension (AUC = 0.8, p < 0.0001).

Conclusions

CT contributes to the non-invasive detection of portopulmonary hypertension when used in a diagnostic algorithm with transthoracic echocardiography. CT may have a role in the pre-liver transplantation triage of patients with portopulmonary hypertension for right-sided heart catheterisation.

Key Points

• CT signs correlate with right-sided heart catheter data in portopulmonary hypertension

• CT adds to the transthoracic echocardiography detection of portopulmonary hypertension

• CT may have a complementary role in pre-liver transplantation triage

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Titel: Portopulmonary hypertension: Improved detection using CT and echocardiography in combination
verfasst von: Anand Devaraj
Robert Loveridge
Diana Bosanac
Konstantinos Stefanidis
William Bernal
Christopher Willars
Julia A. Wendon
Georg Auzinger
Sujal R. Desai
Publikationsdatum: 01.10.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 10/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3289-4

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Portopulmonary hypertension: Improved detection using CT and echocardiography in combination