nach oben

International Journal of Legal Medicine

Erschienen in:

09.06.2016 | Original Article

Postmortem serum levels of total IgE

verfasst von: Lara Tran, Cristian Palmiere

Erschienen in: International Journal of Legal Medicine | Ausgabe 6/2016

Einloggen, um Zugang zu erhalten

Abstract

The first aim of this study was to assess whether non-allergic deaths in non-atopic individuals with increasing postmortem intervals are characterized by progressively greater concentrations of total IgE in postmortem serum from femoral blood. Our second goal was to determine whether traumatic deaths with different survival times, septic deaths, and deaths in individuals suffering from diseases with significant systemic inflammation are systematically characterized by increased concentrations of total IgE in postmortem serum from femoral blood. Four study groups were prospectively and retrospectively formed (non-allergic deaths in non-atopic individuals with increasing postmortem intervals, traumatic deaths in non-atopic individuals with different survival times, deaths possibly related to sepsis in non-atopic individuals, and deaths occurring in non-atopic individuals with disseminated malignancies at autopsy). Unenhanced computed tomography, autopsy, histology, and biochemistry were performed in all cases. First results indicate that increasing postmortem intervals are not associated with progressively increasing postmortem serum IgE levels. Moreover, the obtained results do not reveal that severe trauma, bacterial sepsis, and disseminated malignancies are systematically associated with increased postmortem serum IgE levels, irrespective of survival time duration. Though the usefulness of increased total IgE concentrations in postmortem samples to assess any underlying atopic disposition or death preceded by acute IgE-mediated allergic reaction remains questionable, measurements of total IgE are possible in postmortem serum samples.

McLean-Tooke A, Goulding M, Bundell C, White J, Hollingsworth P (2014) Postmortem serum tryptase levels in anaphylactic and non-anaphylactic deaths. J Clin Pathol 67:134–138CrossRefPubMed

Yunginger JW, Nelson DR, Squillace DL, Jones RT, Holley KE, Hyma BA, Biedrzycki L, Sweeney KG, Sturner WQ, Schwartz LB (1991) Laboratory investigations of death due to anaphylaxis. J Forensic Sci 36:857–865CrossRefPubMed

Palmiere C, Comment L, Mangin P (2014) Allergic reactions following contrast material administration: nomenclature, classification, and mechanisms. Int J Legal Med 128:95–103CrossRefPubMed

Randall B, Butts J, Halsey JF (1995) Elevated postmortem tryptase in the absence of anaphylaxis. J Forensic Sci 40:208–211CrossRefPubMed

Salkie ML, Mitchell I, Revers CW, Karkhanis A, Butt J, Tough S, Green FH (1998) Postmortem serum levels of tryptase and total and specific IgE in fatal asthma. Allergy Asthma Proc 19:131–133CrossRefPubMed

Pumphrey RS, Roberts IS (2000) Postmortem findings after fatal anaphylactic reactions. J Clin Pathol 53:273–276CrossRefPubMedPubMedCentral

Mayer DE, Krauskopf A, Hemmer W, Moritz K, Jarisch R, Reiter C (2011) Usefulness of post mortem determination of serum tryptase, histamine and diamine oxidase in the diagnosis of fatal anaphylaxis. Forensic Sci Int 212:96–101CrossRefPubMed

Horn KD, Halsey JF, Zumwalt RE (2004) Utilization of serum tryptase and immunoglobulin e assay in the postmortem diagnosis of anaphylaxis. Am J Forensic Med Pathol 25:37–43CrossRefPubMed

Fisher MM, Baldo BA (1993) The diagnosis of fatal anaphylactic reactions during anaesthesia: employment of immunoassays for mast cell tryptase and drug-reactive IgE antibodies. Anaesth Intensive Care 21:353–357PubMed

10.

Low I, Stables S (2006) Anaphylactic deaths in Auckland, New Zealand: a review of coronial autopsies from 1985 to 2005. Pathology 38:328–332CrossRefPubMed

11.

DiPiro JT, Hamilton RG, Howdieshell TR, Adkinson NF Jr, Mansberger AR Jr (1992) Total IgE in plasma is elevated after traumatic injury and is associated with sepsis syndrome. Ann Surg 215:460–465CrossRefPubMedPubMedCentral

12.

DiPiro JT, Howdieshell TR, Hamilton RG, Adkinson NF Jr, Mansberger AR Jr (1996) Increased plasma IgE levels in patients with sepsis after traumatic injury. J Allergy Clin Immunol 97:135–136CrossRefPubMed

13.

DiPiro JT, Howdieshell TR, Hamilton RG, Mansberger AR Jr (1998) Immunoglobulin E and eosinophil counts are increased after sepsis in trauma patients. Crit Care Med 26:465–469CrossRefPubMed

14.

Khan BQ, Kemp SF (2011) Pathophysiology of anaphylaxis. Curr Opin Allergy Clin Immunol 11:319–325CrossRefPubMed

15.

Sampson HA, Muñoz-Furlong A, Campbell RL, Adkinson NF Jr, Bock SA, Branum A, Brown SG, Camargo CA Jr, Cydulka R, Galli SJ, Gidudu J, Gruchalla RS, Harlor AD Jr, Hepner DL, Lewis LM, Lieberman PL, Metcalfe DD, O’Connor R, Muraro A, Rudman A, Schmitt C, Scherrer D, Simons FE, Thomas S, Wood JP, Decker WW (2006) Second symposium on the definition and management of anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. Ann Emerg Med 47:373–380CrossRefPubMed

16.

Kemp SF, Lokey RF (2002) Anaphylaxis: a review of causes and mechanisms. J Allergy Clin Immunol 110:341–348CrossRefPubMed

17.

Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, Motala C, Ortega Martell JA, Platts-Mills TA, Ring J, Thien F, Van Cauwenberge P, Williams HC (2004) Revised nomenclature for allergy for global use: report of the nomenclature review committee of the world allergy organization, October 2003. J Allergy Clin Immunol 113:832–836CrossRefPubMed

18.

Finkelman FD (2007) Anaphylaxis: lessons from mouse models. J Allergy Clin Immunol 120:506–515CrossRefPubMed

19.

Sibilano R, Frossi B, Pucillo CE (2014) Mast cell activation: a complex interplay of positive and negative signaling pathways. Eur J Immunol 44:2558–2566CrossRefPubMed

20.

Logsdon SL, Oettgen HC (2015) Anti-IgE therapy: clinical utility and mechanistic insights. Curr Top Microbiol Immunol 388:39–61PubMed

21.

Prussin C, Metcalfe DD (2006) IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 117:S450–S456CrossRefPubMed

22.

He JS, Narayanan S, Subramaniam S, Ho WQ, Lafaille JJ, Curotto de Lafaille MA (2015) Biology of IgE production: IgE cell differentiation and the memory of IgE responses. Curr Top Microbiol Immunol 388:1–19PubMed

23.

Barbee RA, Halonen M, Lebowitz M, Burrows B (1981) Distribution of IgE in a community population sample: correlation with age, sex, and allergen skin test reactivity. J Allergy Clin Immunol 68:106–111CrossRefPubMed

24.

Omenaas E, Bakke P, Elsayed S, Hanoa R, Gulsvbik A (1994) Total and specific serum IgE levels in adults: relationship to sex, age and environmental factors. Clin Exp Allergy 24:530–539CrossRefPubMed

25.

Stone KD, Prussin C, Metcalfe DD (2010) IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 125(2 Suppl 2):S73–S80CrossRefPubMedPubMedCentral

26.

Gonzales-Quintela A, Vidal C, Gude F (2004) Alcohol, IgE and allergy. Addict Biol 9:195–204CrossRef

27.

Nagasaki T, Matsumoto H, Nakaji H, Niimi A, Ito I, Oguma T, Muro S, Inoue H, Iwata T, Tajiri T, Kanemitsu Y, Mishima M (2013) Smoking attenuates the age-related decrease in IgE levels and maintains eosinophilic inflammation. Clin Exp Allergy 43:608–615PubMed

28.

Spellberg B, Edwards JE Jr (2001) Type 1/type 2 immunity in infectious diseases. Clin Infect Dis 32:76–102CrossRefPubMed

29.

Anthony RM, Rutitzky LI, Urban JF Jr, Stadecker MJ, Gause WC (2007) Protective immune mechanisms in helminth infection. Nat Rev Immunol 7:975–987CrossRefPubMedPubMedCentral

30.

Pearce EJ, M Kane C, Sun J, J Taylor J, McKee AS, Cervi L (2004) Th2 response polarization during infection with the helminth parasite Schistosoma mansoni. Immunol Rev 201:117–126

31.

Akdis M, Trautmann A, Klunker S, Daigle I, Kucuksezer UC, Deglmann W, Disch R, Blaser K, Akdis CA (2003) T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells. FASEB J 17:1026–1035CrossRefPubMed

32.

Coe JI (1993) Postmortem chemistry update. Emphasis on forensic application. Am J Forensic Med Pathol 14(2):91–117CrossRefPubMed

33.

Brazinsky JH, Kellenberger RE (1970) Comparison of immunoglobulin analyses of antemortem and postmortem sera. Am J Clin Pathol 54:622–624CrossRefPubMed

34.

McCormick GM (1972) Nonanatomic postmortem techniques: postmortem serology. J Forensic Sci 17:57–62CrossRefPubMed

35.

Hoffman DR, Wood CL, Hudson P (1983) Demonstration of IgE and IgG antibodies against venoms in the blood of victims of fatal sting anaphylaxis. J Allergy Clin Immunol 71:193–196CrossRefPubMed

36.

Schwartz HJ, Yunginger JW, Teigland JD, Sutheimer C, Hiss Y (1984) Sudden death due to stinging insect hypersensitivity: postmortem demonstration of IgE antivenom antibodies in a fatal case. Am J Clin Pathol 81:794–795

37.

Schwartz HJ, Squillace DL, Sher TH, Teigland JD, Yunginger JW (1986) Studies in stinging insect hypersensitivity: postmortem demonstration of antivenom IgE antibodies in possible sting-related sudden death. Am J Clin Pathol 85:607–610CrossRefPubMed

38.

Riches KJ, Gillis D, James RA (2002) An autopsy approach to bee sting-related deaths. Pathology 34:257–262CrossRefPubMed

39.

Sterzik V, Drendel V, Will M, Bonhert M (2012) Suicide of a man with known allergy to fish protein by ingesting tinned fish. Forensic Sci Int 221:4–6CrossRef

40.

Unkrig S, Hagemeier L, Madea B (2010) Postmortem diagnostics of assumed food anaphylaxis in an unexpected death. Forensic Sci Int 198:1–4CrossRef

41.

Da Broi U, Moreschi C (2011) Post-mortem diagnosis of anaphylaxis: a difficult task in forensic medicine. Forensic Sci Int 204:1–5CrossRefPubMed

42.

Edston E, van Hage-Hamsten M, Johansson SG (1996) Tryptase—at last a useful diagnostic marker for anaphylactic death. Allergy 51:443–445PubMed

43.

Carson HJ, Cook BA (2009) Mast cell tryptase in a case of anaphylaxis due to repeat antibiotic exposure. Leg Med (Tokyo) 11:234–236CrossRef

Titel: Postmortem serum levels of total IgE
verfasst von: Lara Tran
Cristian Palmiere
Publikationsdatum: 09.06.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: International Journal of Legal Medicine / Ausgabe 6/2016
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-016-1398-0

Springer Medizin

Postmortem serum levels of total IgE

Abstract

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2016

Determination of the unbound fraction of R- and S-methadone in human brain

The completely fused medial clavicular epiphysis in high-frequency ultrasound scans as a diagnostic criterion for forensic age estimations in the living

Development of new PCR multiplex system by the simultaneous detection of 10 miniSTRs, SE33, Penta E, Penta D, and four Y-STRs

Population genetics of 23 Y-STR loci in the Mongolian minority population in Inner Mongolia of China

Death eaters respond to the dark mark of decomposition day and night: observations of initial insect activity on piglet carcasses

Quantification of fatal helium exposure following self-administration

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie