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Erschienen in:
01.06.2011 | Musculoskeletal
Prediction of bone loss in elderly female subjects by MR perfusion imaging and spectroscopy
Erschienen in: European Radiology | Ausgabe 6/2011
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Objective
To determine whether MR perfusion indices or marrow fat content at baseline can predict areal bone mineral density (BMDa) loss.
Methods
Repeat dual x-ray absorptiometry (DXA) of the hip was performed in female subjects at 2 years (n = 52) and 4 years (n = 45) following baseline MR perfusion imaging and spectroscopy of the hip.
Results
Percentage reduction in femoral neck BMDa at 4 years post-baseline was greater in subjects with below median acetabulum enhancement slope (Eslope) (−5.6 ± 1.2 Vs −1.1 ± 1.2 (mean ± standard error) p = 0.014) or muscle maximum enhancement (Emax) (−5.7 ± 1.2 Vs −0.23 ± 1.2, p = 0.009) after adjusting for baseline co-variables. Baseline MR parameters correlated with reduction in BMDa at 4 years (acetabulum Eslope
r = 0.517, p = 0.0003; muscle Emax
r = 0.306, p = 0.043) as well as traditionally applied clinical risk factors. Acetabulum Eslope, femoral neck Emax and marrow fat content at baseline had sensitivities of 89%, 81% and 72% respectively at distinguishing between fast (>1%/annum) (n = 18) and slow (<1%/annum) (n = 27) BMD losers.
Conclusion
Elderly female subjects with reduced perfusion indices at baseline had increased femoral neck bone loss at 4 years. Selected perfusion indices and marrow fat content have a moderate to high sensitivity in discriminating between fast and slow bone losers.