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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

Primary pulmonary mucoepidermoid carcinoma: an analysis of 21 cases

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Jun-jie Xi, Wei Jiang, Shao-hua Lu, Chun-yan Zhang, Hong Fan, Qun Wang
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-232) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

Xi JJ collected information of the cases, carried out statistic analysis, conducted follow-ups, and drafted the manuscript. Jiang W collected information of the cases and participated in the revision of the manuscript. Lu SH verified the diagnosis and performed immunohistochemistry. Zhang CY carried out the detection of gene mutation. Fan H participated in collecting information of cases and manuscript drafting. Wang Q conceived the article and participated in the manuscript drafting. All authors read and approved the final manuscript.

Abstract

Background

The optimal treatment for pulmonary mucoepidermoid carcinoma (MEC), a rare type of tumor, has not been established yet. This study analyzed the survival of pulmonary MEC patients and attempted to find clues for optimal treatment.

Methods

A total of 21 patients with pulmonary MEC from November 2004 to January 2011 were included in the investigation. Immunohistochemistry, epidermal growth factor receptor (EGFR) mutation, and survival were retrospectively studied.

Results

Among the 21 pulmonary MEC patients, 17 were diagnosed with low-grade malignancy and 4 with high-grade malignancy through pathological examination. The prognosis was found to be poor in the presence of lymph nodes. The expression rates of EGFR and HER2 were 28.6% and 0%, respectively, which correlated with neither grade nor prognosis. The mutation rate of EGFR was 0. Log-rank test results indicated that age, grade, lymph node metastasis, and tumor-node-metastasis stage were prognostic factors.

Conclusion

Age, grade, lymph node metastasis and tumor-node-metastasis stage correlate with the survival of pulmonary MEC patients.

Trial registration

This study was approved and registered by the Ethics Committee of Zhongshan Hospital. Written informed consent was obtained from all participants prior to treatment.
Zusatzmaterial
Authors’ original file for figure 1
12957_2012_1151_MOESM1_ESM.tiff
Authors’ original file for figure 2
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Authors’ original file for figure 3
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Authors’ original file for figure 4
12957_2012_1151_MOESM4_ESM.tiff
Literatur
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