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Digestive Diseases and Sciences
Erschienen in: Digestive Diseases and Sciences 5/2008

01.05.2008 | Original Paper

Prognostic and Predictive Value of Thymidylate Synthase Expression in Colon Cancer

verfasst von: Gerasimos Tsourouflis, Stamatios E. Theocharis, Anastasia Sampani, Athina Giagini, Alkiviadis Kostakis, Gregory Kouraklis

Erschienen in: Digestive Diseases and Sciences | Ausgabe 5/2008

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Abstract

Thymidylate synthase (TS) is an enzyme responsible for DNA synthesis. Its competitive inhibition constitutes the major mechanism of the antitumor effect of 5-fluorouracil (5-FU) therapy, which significantly improves the survival rate of colon cancer patients. The aim of our study was to examine the clinical importance of TS expression in colon cancer patients and to correlate its expression with various clinicopathological parameters, tumor proliferative capacity, cell cycle-related molecules’ expression and patients’ survival. Of the 71 colon cancer patients studied, 51 (71.8%) tested positive for TS, with the positive result being statistically significantly correlated with patients’ gender (P = 0.012), tumor histological grade (P = 0.032), vascular invasion (P = 0.017) and the expression of cyclin E, pRb and p16 (P = 0.042, P = 0.001 and P = 0.001, respectively). The overall 5-year survival rate was 40% for TS-positive patients and 68.6% for TS-negative ones (P = 0.0134); in patients aged >70 years, this was 30 and 77.8%, respectively (P = 0.0008). In a multivariate analysis of survival, TS expression proved to be of prognostic significance (P = 0.0174). Our findings support evidence for the clinical importance of TS expression in colon cancer patients and define it as an independent prognostic risk factor.
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Metadaten
Titel
Prognostic and Predictive Value of Thymidylate Synthase Expression in Colon Cancer
verfasst von
Gerasimos Tsourouflis
Stamatios E. Theocharis
Anastasia Sampani
Athina Giagini
Alkiviadis Kostakis
Gregory Kouraklis
Publikationsdatum
01.05.2008
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 5/2008
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-007-0008-x

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