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11.10.2015 | Chest

Prognostic impact of nomogram based on whole tumour size, tumour disappearance ratio on CT and SUVmax on PET in lung adenocarcinoma

verfasst von: So Hee Song, Joong Hyun Ahn, Ho Yun Lee, Geewon Lee, Joon Young Choi, Jun Kang, Eun Young Kim, Joungho Han, O. Jung Kwon, Kyung Soo Lee, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Young Mog Shim

Erschienen in: European Radiology | Ausgabe 6/2016

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Abstract

Objectives

Lung adenocarcinoma frequently manifests as subsolid nodules, and the solid portion and ground-glass-opacity (GGO) portion on CT have different prognostic significance. Therefore, current T descriptor, defined as the whole tumour diameter without discrimination between solid and GGO, is insufficient. We aimed to determine the prognostic significance of solid tumour size and attempt to include prognostic factors such as tumour disappearance rate (TDR) on CT and SUVmax on PET/CT.

Methods

Five hundred and ninety-five patients with completely resected lung adenocarcinoma were analyzed. We developed a nomogram using whole tumour size, TDR, and SUVmax. External validation was performed in another 102 patients.

Results

In patients with tumours measuring ≤2 cm and >2 to 3 cm, disease free survival (DFS) was significantly associated with solid tumour size (P < 0.001), but not with whole tumour size (P = 0.052). Developed nomogram was significantly superior to the conventional T stage (area under the curve of survival ROC; P = 0.013 by net reclassification improvement) in stratification of patient survival. In the external validation group, significant difference was noted in DFS according to proposed T stage (P = 0.009).

Conclusions

Nomogram-based T descriptors provide better prediction of survival and assessment of individual risks than conventional T descriptors.

Key points

• Current measurement of whole tumour diameter including ground-glass opacity is insufficient

• TDR enables differentiation between invasive solid portion and non-invasive GGO portion

• SUVmax demonstrates the biological aggressiveness of the tumour

• We developed a nomogram using whole tumour size, TDR, and SUVmax

• Nomogram-based clinical T descriptors provide better prediction of survival

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Titel: Prognostic impact of nomogram based on whole tumour size, tumour disappearance ratio on CT and SUVmax on PET in lung adenocarcinoma
verfasst von: So Hee Song
Joong Hyun Ahn
Ho Yun Lee
Geewon Lee
Joon Young Choi
Jun Kang
Eun Young Kim
Joungho Han
O. Jung Kwon
Kyung Soo Lee
Hong Kwan Kim
Yong Soo Choi
Jhingook Kim
Young Mog Shim
Publikationsdatum: 11.10.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 6/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-4029-0

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Prognostic impact of nomogram based on whole tumour size, tumour disappearance ratio on CT and SUVmax on PET in lung adenocarcinoma

Abstract

Objectives

Methods

Results

Conclusions

Key points

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Abstract

Objectives

Methods

Results

Conclusions

Key points

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