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Surgery Today
Erschienen in: Surgery Today 12/2020

17.06.2020 | Original Article

Prognostic nutritional index and postoperative outcomes in patients with colon cancer after laparoscopic surgery

verfasst von: Tetsuro Tominaga, Toshiya Nagasaki, Takashi Akiyoshi, Yosuke Fukunaga, Satoru Honma, Tomoyuki Nagaoka, Shinpei Matsui, Hironori Minami, Shun Miyanari, Tomohiro Yamaguchi, Masashi Ueno

Erschienen in: Surgery Today | Ausgabe 12/2020

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Abstract

Purpose

The prognostic nutritional index (PNI) is calculated using the serum albumin and peripheral lymphocyte counts. We sought to assess the correlation between the preoperative PNI and postoperative outcomes in patients with colon cancer treated with laparoscopic surgery.

Methods

We included 896 colon cancer patients who underwent curative laparoscopic colectomy between January 2013 and March 2016. To identify any predictors of the postoperative outcomes, we compared the clinical characteristics and immunonutritional parameters, including the PNI, between patients classified as the Clavien–Dindo grade 2 or higher (n = 99) with those classified as grade 0 or 1 (n = 797).

Results

A longer surgical time and a preoperative low PNI (< 49.8) (odds ratio; 1.913, p = 0.002) were independent predictors of postoperative complications according to a multivariate analysis. A preoperative low PNI was significantly associated with an older age, a lower performance status, a lower BMI, higher CEA levels, an advanced T status, lymph node metastasis, a longer operative time, a higher blood loss, a larger tumor size, treatment with a combined resection, a longer time to bowel recovery, a longer postoperative hospital stay, and a poor overall survival.

Conclusions

A preoperative low PNI was found to be significantly associated with the incidence of postoperative complications, an advanced tumor status, and a poor prognosis. Further research is needed to understand how to best clinically utilize this promising parameter.
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Metadaten
Titel
Prognostic nutritional index and postoperative outcomes in patients with colon cancer after laparoscopic surgery
verfasst von
Tetsuro Tominaga
Toshiya Nagasaki
Takashi Akiyoshi
Yosuke Fukunaga
Satoru Honma
Tomoyuki Nagaoka
Shinpei Matsui
Hironori Minami
Shun Miyanari
Tomohiro Yamaguchi
Masashi Ueno
Publikationsdatum
17.06.2020
Verlag
Springer Singapore
Erschienen in
Surgery Today / Ausgabe 12/2020
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-020-02050-2

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