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16.10.2017 | Original Article

Prognostic value of volumetric FDG PET/CT parameters in patients with oral tongue squamous cell carcinoma who were treated by superselective intra-arterial chemoradiotherapy

verfasst von: Satoko Suzuki-Shibata, Yayoi Yamamoto, Tetsuo Yoshida, Nobutaka Mizoguchi, Tetsuo Nonaka, Akira Kubota, Hiroto Narimatsu, Yohei Miyagi, Toshiaki Kobayashi, Tomohiro Kaneta, Tomio Inoue

Erschienen in: Japanese Journal of Radiology | Ausgabe 12/2017

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Abstract

Purpose

This study aimed to evaluate the predictive and prognostic value of FDG PET/CT-based volumetric parameters in patients with oral tongue squamous cell carcinoma (OTSCC) treated by superselective intra-arterial chemoradiotherapy (IA-CRT).

Methods

We conducted a retrospective study including 33 patients with biopsy-proven OTSCC between May 2007 and February 2016. All of the patients were treated by IA-CRT. Pretreatment SUV_max and metabolic tumor volume (MTV) of the primary tumor were measured. The SUV thresholds of 2.5 and 5.0 were used. Progression-free survival (PFS) and overall survival (OS) were chosen as endpoints to evaluate prognosis. Univariate and multivariate analyses were performed to assess the potential independent effect of FDG PET/CT parameters.

Results

The median follow-up for surviving patients was 40.7 months (range 6.0–107.5 months). In univariate and multivariate analyses, SUV_max and MTV (5.0) were independent prognostic factors for PFS. In univariate analysis, SUV_max failed to predict OS. MTV (5.0) was a significant prognostic factor for OS, but multivariate analysis failed to show statistical independence because it could not exclude the possibility of an artifact due to N stage.

Conclusions

FDG PET/CT-based volumetric parameters may be significant prognostic markers for survival of patients with OTSCC who are treated by IA-CRT.

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Titel: Prognostic value of volumetric FDG PET/CT parameters in patients with oral tongue squamous cell carcinoma who were treated by superselective intra-arterial chemoradiotherapy
verfasst von: Satoko Suzuki-Shibata
Yayoi Yamamoto
Tetsuo Yoshida
Nobutaka Mizoguchi
Tetsuo Nonaka
Akira Kubota
Hiroto Narimatsu
Yohei Miyagi
Toshiaki Kobayashi
Tomohiro Kaneta
Tomio Inoue
Publikationsdatum: 16.10.2017
Verlag: Springer Japan
Erschienen in: Japanese Journal of Radiology / Ausgabe 12/2017
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-017-0686-z

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Prognostic value of volumetric FDG PET/CT parameters in patients with oral tongue squamous cell carcinoma who were treated by superselective intra-arterial chemoradiotherapy

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Purpose

Methods

Results

Conclusions

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