Erschienen in:
14.11.2019 | Prolactinoma
A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas
verfasst von:
B. G. Sant’ Anna, N. R. C. Musolino, M. R. Gadelha, C. Marques, M. Castro, P. C. L. Elias, L. Vilar, R. Lyra, M. R. A. Martins, A. R. P. Quidute, J. Abucham, D. Nazato, H. M. Garmes, M. L. C. Fontana, C. L. Boguszewski, C. B. Bueno, M. A. Czepielewski, E. S. Portes, V. S. Nunes-Nogueira, A. Ribeiro-Oliveira Jr., R. P. V. Francisco, M. D. Bronstein, A. Glezer
Erschienen in:
Pituitary
|
Ausgabe 2/2020
Einloggen, um Zugang zu erhalten
Abstract
Objective
To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort.
Methods
The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study,
Results
We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases.
Conclusions
Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.