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Inflammation
Erschienen in: Inflammation 4/2017

13.05.2017 | ORIGINAL ARTICLE

Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund’s Complete Adjuvant-Induced Arthritis in Rats

verfasst von: Chen Wenjin, Wang Jianwei

Erschienen in: Inflammation | Ausgabe 4/2017

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Abstract

The anti-inflammatory property of gentianine (GE) aroused our interest. To investigate the effect of GE on Freund’s complete adjuvant (FCA)-induced arthritis in rats was the aim of this study. Adjuvant-induced arthritis (AA) was induced by the administration of 0.1 ml FCA in the surface of hind paw. Diclofenac sodium (DS) and Fasudil were administered as positive controls. Downregulation of cytokines including interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and tumor necrosis factor-alpha (TNF-α) revealed anti-inflammatory effect of GE, which was consisted with pathological conditions of rat paws. In addition, western blot analysis revealed that GE could strikingly suppressed the expressions of Rho/NF-κB signaling pathways as well as TGF-β/smad-3 pathways. In conclusion, data indicated that GE might contribute to treat arthritis as a potential therapeutic candidate.
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Metadaten
Titel
Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund’s Complete Adjuvant-Induced Arthritis in Rats
verfasst von
Chen Wenjin
Wang Jianwei
Publikationsdatum
13.05.2017
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 4/2017
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-017-0583-8

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