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Virchows Archiv

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31.01.2018 | Invited Editorial

Pulmonary neuroendocrine carcinomas—evidence for a spectrum of differentiation

verfasst von: Annikka Weissferdt

Erschienen in: Virchows Archiv | Ausgabe 4/2018

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Excerpt

In this issue, Pelosi and colleagues present the results of a gene alteration analysis of a large series of pulmonary neuroendocrine carcinomas. This study provides molecular support for the concept that carcinoid tumors can transform into high-grade neuroendocrine carcinomas through the acquisition of additional molecular alterations. This concept challenges the current and widely held belief that carcinoid tumors are different histogenetic entities from the high-grade neuroendocrine carcinomas thereby denying the existence of any transitional forms. …

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Desmeules P, Sabari J, Santos-Zabala ML, Litvak AM, Pietanza MC, Poirier JT, Rudin CM, Klimstra DS, Travis W, Rekhtman N (2017) Metastatic lung carcinoid tumors: evidence of proliferation rate progression at metastatic sites. Mod Pathol 30:475A

Titel: Pulmonary neuroendocrine carcinomas—evidence for a spectrum of differentiation
verfasst von: Annikka Weissferdt
Publikationsdatum: 31.01.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 4/2018
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-018-2308-2

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Pulmonary neuroendocrine carcinomas—evidence for a spectrum of differentiation

Excerpt

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Excerpt

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