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01.10.2012 | Urogenital

Quantitative elastography of renal transplants using supersonic shear imaging: a pilot study

verfasst von: Nicolas Grenier, Séverine Poulain, Sébastien Lepreux, Jean-Luc Gennisson, Benjamin Dallaudière, Yann Lebras, Eric Bavu, Aude Servais, Vannary Meas-Yedid, Mathieu Piccoli, Thomas Bachelet, Mickaël Tanter, Pierre Merville, Lionel Couzi

Erschienen in: European Radiology | Ausgabe 10/2012

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Abstract

Purpose

To evaluate the reliability of quantitative ultrasonic measurement of renal allograft elasticity using supersonic shear imaging (SSI) and its relationship with parenchymal pathological changes.

Materials and methods

Forty-three kidney transplant recipients (22 women, 21 men) (mean age, 51 years; age range, 18–70 years) underwent SSI elastography, followed by biopsy. The quantitative measurements of cortical elasticity were performed by two radiologists and expressed in terms of Young’s modulus (kPa). Intra- and inter-observer reproducibility was assessed (Kruskal-Wallis test and Bland-Altman analysis), as well as the correlation between elasticity values and clinical, biological and pathological data (semi-quantitative Banff scoring). Interstitial fibrosis was evaluated semi-quantitatively by the Banff score and measured by quantitative image analysis.

Results

Intra- and inter-observer variation coefficients of cortical elasticity were 20 % and 12 %, respectively. Renal cortical stiffness did not correlate with any clinical parameters, any single semi-quantitative Banff score or the level of interstitial fibrosis; however, a significant correlation was observed between cortical stiffness and the total Banff scores of chronic lesions and of all elementary lesions (R = 0.34, P = 0.05 and R = 0.41, P = 0.03,respectively).

Conclusion

Quantitative measurement of renal cortical stiffness using SSI is a promising non-invasive tool to evaluate global histological deterioration.

Key Points

• Supersonic shear imaging elastography can measure cortical stiffness in renal transplants

• The level of cortical stiffness is correlated with the global degree of tissue lesions

• The global histological deterioration of transplanted kidneys can be quantified using elastography

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Titel: Quantitative elastography of renal transplants using supersonic shear imaging: a pilot study
verfasst von: Nicolas Grenier
Séverine Poulain
Sébastien Lepreux
Jean-Luc Gennisson
Benjamin Dallaudière
Yann Lebras
Eric Bavu
Aude Servais
Vannary Meas-Yedid
Mathieu Piccoli
Thomas Bachelet
Mickaël Tanter
Pierre Merville
Lionel Couzi
Publikationsdatum: 01.10.2012
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 10/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2471-9

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Quantitative elastography of renal transplants using supersonic shear imaging: a pilot study