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11.03.2020 | Original Article

Quantitative pharmacokinetic analysis of high-temporal-resolution dynamic contrast-enhanced MRI to differentiate the normal-appearing pituitary gland from pituitary macroadenoma

verfasst von: Kiyohisa Kamimura, Masanori Nakajo, Tomohide Yoneyama, Manisha Bohara, Ryota Nakanosono, Shingo Fujio, Takashi Iwanaga, Marcel Dominik Nickel, Hiroshi Imai, Yoshihiko Fukukura, Takashi Yoshiura

Erschienen in: Japanese Journal of Radiology | Ausgabe 7/2020

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Abstract

Purpose

To evaluate the usefulness of high-temporal-resolution dynamic contrast-enhanced (DCE) MRI and quantitative pharmacokinetic analysis to differentiate the normal-appearing pituitary gland from a pituitary macroadenoma.

Materials and methods

Twenty-seven patients with macroadenomas underwent preoperative DCE-MRI with a temporal resolution of 5 s using compressed sensing to obtain pharmacokinetic parameters. Two independent observers localized the normal-appearing pituitary gland on post-contrast T1-weighted images before and after referring to the corresponding K^trans maps. Agreements between the localizations and intraoperative findings were evaluated using the kappa statistics. The Mann–Whitney U test was used to compare the pharmacokinetic parameters of the normal-appearing pituitary gland and adenoma.

Results

For both observers, the agreement between the MRI-based localization and the intraoperative findings increased after referring to the K^trans maps (observer 1, 0.930–1; observer 2, 0.636–0.855). The normal-appearing pituitary gland had significantly higher K^trans [/min] (1.50 ± 0.80 vs 0.58 ± 0.49, P < 0.0001), k_ep [/min] (3.19 ± 1.29 vs 2.15 ± 1.18, P = 0.0049), and v_e (0.43 ± 0.15 vs 0.25 ± 0.17, P = 0.0003) than adenoma.

Conclusion

High-temporal-resolution DCE-MRI and quantitative pharmacokinetic analysis help accurately localize the normal-appearing pituitary gland in patients with macroadenomas. The normal-appearing pituitary gland was characterized by higher K^trans, k_ep, and v_e than macroadenoma.

Condensed abstract

Dynamic contrast-enhanced MRI with high-temporal-resolution using compressed sensing was used for quantitative pharmacokinetic analysis of pituitary macroadenomas. An observer study, the use of K^trans maps improved accuracy in localizing the normal-appearing pituitary gland. As compared to an adenoma, the normal-appearing pituitary gland had significantly higher K^trans, k_ep, and v_e values.

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Titel: Quantitative pharmacokinetic analysis of high-temporal-resolution dynamic contrast-enhanced MRI to differentiate the normal-appearing pituitary gland from pituitary macroadenoma
verfasst von: Kiyohisa Kamimura
Masanori Nakajo
Tomohide Yoneyama
Manisha Bohara
Ryota Nakanosono
Shingo Fujio
Takashi Iwanaga
Marcel Dominik Nickel
Hiroshi Imai
Yoshihiko Fukukura
Takashi Yoshiura
Publikationsdatum: 11.03.2020
Verlag: Springer Singapore
Erschienen in: Japanese Journal of Radiology / Ausgabe 7/2020
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-020-00942-4

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Quantitative pharmacokinetic analysis of high-temporal-resolution dynamic contrast-enhanced MRI to differentiate the normal-appearing pituitary gland from pituitary macroadenoma