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Molecular Imaging and Biology

Erschienen in:

16.09.2019 | Review Article

Quantum Dot-Based Simultaneous Multicolor Imaging

verfasst von: Wenxia Wang, Zhen Liu, Xiaoli Lan

Erschienen in: Molecular Imaging and Biology | Ausgabe 4/2020

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Abstract

Quantum dots have attracted a great deal of attention among researchers in optical imaging because of their unique physicochemical properties. Their adjustable size allows quantum dots to emit visible fluorescence with different wavelengths excited by a single light source, allowing them to play an unmatched role in multitarget simultaneous multicolor imaging of tissues and cells compared with other molecular biotechnologies and traditional fluorescent materials. This technology affords real-time observation in situ of multiple biomarkers, allowing us to quantify their expression levels, and helping us to gain a deeper understanding of the interactions among biomolecules and the relationship between biomolecules and disease occurrence, progression, and prognosis. This has potential to aid in clinical diagnosis and treatment decision making.

Smith AM, Duan H, Mohs AM, Nie S (2008) Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv Drug Deliv Rev 60:1226–1240PubMedPubMedCentral

Kairdolf BA, Smith AM, Stokes TH, Wang MD, Young AN, Nie S (2013) Semiconductor quantum dots for bioimaging and biodiagnostic applications. Annu Rev Anal Chem 6:143–162

Wang LW, Peng CW, Chen C, Li Y (2015) Quantum dots-based tissue and in vivo imaging in breast cancer researches: current status and future perspectives. Breast Cancer Res Treat 151:7–17PubMedPubMedCentral

Yong K-T, Roy I, Law W-C, Hu R (2010) Synthesis of cRGD-peptide conjugated near-infrared CdTe/ZnSe core –shell quantum dots for in vivo cancer targeting and imaging. Chem Commun 46:7136–7138

Tang J, Huang N, Zhang X, Zhou T, Tan Y, Pi J, Pi L, Cheng S, Zheng H, Cheng Y (2017) Aptamer-conjugated PEGylated quantum dots targeting epidermal growth factor receptor variant III for fluorescence imaging of glioma. Int J Nanomedicine 12:3899–3911PubMedPubMedCentral

Phillips E, Penate-Medina O, Zanzonico PB et al (2014) Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe. Sci Transl Med 6:149–172

Bae PK, Chung BH (2014) Multiplexed detection of various breast cancer cells by perfluorocarbon/quantum dot nanoemulsions conjugated with antibodies. Nano Converg 1:23PubMedPubMedCentral

Wang Y, Wang Y, Chen G, Li Y, Xu W, Gong S (2017) Quantum-dot-based theranostic micelles conjugated with an anti-EGFR nanobody for triple-negative breast cancer therapy. ACS Appl Mater Interfaces 9:30297–30305PubMedPubMedCentral

Radenkovic D, Kobayashi H, Remsey-Semmelweis E, Seifalian AM (2016) Quantum dot nanoparticle for optimization of breast cancer diagnostics and therapy in a clinical setting. Nanomedicine 12:1581–1592PubMed

10.

Gaponik N, Talapin DV, Rogach AL, Hoppe K, Shevchenko EV, Kornowski A, Eychmüller A, Weller H (2002) Thiol-capping of CdTe nanocrystals: an alternative to organometallic synthetic routes. J Phys Chem B 106(29):7177–7185

11.

Chan WC, Nie S (1998) Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281:2016–2018

12.

Lin G, Wang X, Yin F, Yong KT (2015) Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots. Int J Nanomedicine 10:335–345PubMedPubMedCentral

13.

Bruchez M, Moronne M, Gin P et al (1998) Semiconductor nanocrystals as fluorescent biological labels. Science 281:2013–2016PubMed

14.

Tasso M, Singh MK, Giovanelli E, Fragola A, Loriette V, Regairaz M, Dautry F, Treussart F, Lenkei Z, Lequeux N, Pons T (2015) Oriented bioconjugation of unmodified antibodies to quantum dots capped with copolymeric ligands as versatile cellular imaging tools. ACS Appl Mater Interfaces 7:26904–26913PubMed

15.

Alam F, Yadav N (2013) Potential applications of quantum dots in mapping sentinel lymph node and detection of micrometastases in breast carcinoma. J Breast Cancer 16:1–11PubMedPubMedCentral

16.

Ren D, Wang B, Hu C, Zheng Y (2017) Quantum dot probes for cellular analysis. Anal Methods 9:2621–2632

17.

Wu XY, Liu HJ, Liu JQ, Haley KN, Treadway JA, Larson JP, Ge N, Peale F, Bruchez MP (2003) Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat Biotechnol 21:41–46PubMed

18.

Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A (2002) In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 298:1759–1762PubMed

19.

Gao X, Cui Y, Levenson RM, Chung LWK, Nie S (2004) In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 22:969–976

20.

Yuan JP, Wang LW, Qu AP et al (2015) Quantum dots-based quantitative and in situ multiple imaging on ki67 and cytokeratin to improve ki67 assessment in breast cancer. PLoS One 10:e0122734PubMedPubMedCentral

21.

Yang XQ, Chen C, Peng CW, Hou JX, Liu SP, Qi CB, Gong YP, Zhu XB, Pang DW, Li Y (2011) Quantum dot-based quantitative immune-fluorescence detection and spectrum analysis of epidermal growth factor receptor in breast cancer tissue arrays. Int J Nanomedicine 6:2265–2273PubMedPubMedCentral

22.

Zhang H, Sachdev D, Wang C, Hubel A, Gaillard-Kelly M, Yee D (2009) Detection and downregulation of type I IGF receptor expression by antibody conjugated quantum dots in breast cancer cells. Breast Cancer Res Treat 114:277–285PubMed

23.

Chen C, Peng J, Xia HS, Yang GF, Wu QS, Chen LD, Zeng LB, Zhang ZL, Pang DW, Li Y (2009) Quantum dots-based immunofluorescence technology for the quantitative determination of HER2 expression in breast cancer. Biomaterials 30:2912–2918PubMed

24.

Chen C, Xia HS, Gong YP, Peng J, Peng CW, Hu MB, Zhu XB, Pang DW, Sun SR, Li Y (2010) The quantitative detection of total HER2 load by quantum dots and the identification of a new subtype of breast cancer with different 5-year prognosis. Biomaterials 31:8818–8825PubMed

25.

Chen C, Sun SR, Gong YP, Qi CB, Peng CW, Yang XQ, Liu SP, Peng J, Zhu S, Hu MB, Pang DW, Li Y (2011) Quantum dots-based molecular classification of breast cancer by quantitative spectroanalysis of hormone receptors and HER2. Biomaterials 32:7592–7599PubMed

26.

Yang K, Zhang FJ, Tang H et al (2011) In-vivo imaging of oral squamous cell carcinoma by EGFR monoclonal antibody conjugated near-infrared quantum dots in mice. Int J Nanomedicine 6:1739–1745PubMedPubMedCentral

27.

Chen LD, Liu J, Yu XF, He M, Pei XF, Tang ZY, Wang QQ, Pang DW, Li Y (2008) The biocompatibility of quantum dot probes used for the targeted imaging of hepatocellular carcinoma metastasis. Biomaterials 29:4170–4176PubMed

28.

Park Y, Ryu YM, Wang T et al (2017) Colorectal cancer diagnosis using enzyme-sensitive ratiometric fluorescence dye and antibody–quantum dot conjugates for multiplexed detection. Adv Funct Mater 28:1703450

29.

Miyashita M, Gonda K, Tada H, Watanabe M, Kitamura N, Kamei T, Sasano H, Ishida T, Ohuchi N (2016) Quantitative diagnosis of HER2 protein expressing breast cancer by single-particle quantum dot imaging. Cancer Med 5:2813–2824PubMedPubMedCentral

30.

Bilan R, Nabiev I, Sukhanova A (2016) Quantum dot-based nanotools for bioimaging, diagnostics, and drug delivery. Chembiochem 17:2103–2114PubMed

31.

Glazer ES, Curley SA (2010) Radiofrequency field-induced thermal cytotoxicity in cancer cells treated with fluorescent nanoparticles. Cancer 116:3285–3293PubMedPubMedCentral

32.

Mukherjee A, Shim Y, Myong Song J (2016) Quantum dot as probe for disease diagnosis and monitoring. Biotechnol J 11:31–42PubMed

33.

Smith AM, Duan HW, Rhyner MN, Ruan G, Nie S (2006) A systematic examination of surface coatings on the optical and chemical properties of semiconductor quantum dots. Phys Chem Chem Phys 8:3895–3903PubMed

34.

Xing Y, Chaudry Q, Shen C, Kong KY, Zhau HE, Chung LW, Petros JA, O’Regan RM, Yezhelyev MV, Simons JW, Wang MD, Nie S (2007) Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry. Nat Protoc 2:1152–1165PubMed

35.

Huang DH, Peng XH, Su L, Wang D, Khuri FR, Shin DM, Chen Z(G) (2010) Comparison and optimization of multiplexed quantum dot-based immunohistofluorescence. Nano Res 3:61–68

36.

Chen C, Peng J, Sun SR, Peng CW, Li Y, Pang DW (2012) Tapping the potential of quantum dots for personalized oncology: current status and future perspectives. Nanomedicine 7:411–428PubMed

37.

Chen C, Peng J, Xia H, Wu Q, Zeng L, Xu H, Tang H, Zhang Z, Zhu X, Pang D, Li Y (2010) Quantum-dot-based immunofluorescent imaging of HER2 and ER provides new insights into breast cancer heterogeneity. Nanotechnology 21:095101PubMed

38.

Liu XL, Peng CW, Chen C, Yang XQ, Hu MB, Xia HS, Liu SP, Pang DW, Li Y (2011) Quantum dots-based double-color imaging of HER2 positive breast cancer invasion. Biochem Biophys Res Commun 409:577–582PubMed

39.

Peng CW, Liu XL, Chen C, Liu X, Yang XQ, Pang DW, Zhu XB, Li Y (2011) Patterns of cancer invasion revealed by QDs-based quantitative multiplexed imaging of tumor microenvironment. Biomaterials 32:2907–2917PubMed

40.

Peng CW, Tian Q, Yang GF et al (2012) Quantum-dots based simultaneous detection of multiple biomarkers of tumor stromal features to predict clinical outcomes in gastric cancer. Biomaterials 33:5742–5752PubMed

41.

Jang JY, Jeon YK, Kim CW (2010) Degradation of HER2/neu by ANT2 shRNA suppresses migration and invasiveness of breast cancer cells. BMC Cancer 10:391PubMedPubMedCentral

42.

Bao W, Fu HJ, Jia LT, Zhang Y, Li W, Jin BQ, Yao LB, Chen SY, Yang AG (2010) HER2-mediated upregulation of MMP-1 is involved in gastric cancer cell invasion. Arch Biochem Biophys 499:49–55PubMed

43.

Kosaka N, Ogawa M, Sato N, Choyke PL, Kobayashi H (2009) In vivo real-time, multicolor, quantum dot lymphatic imaging. J Investig Dermatol 129:2818–2822PubMed

44.

Si C, Zhang Y, Lv X, Yang W et al (2015) In vivo lymph node mapping by cadmium tellurium quantum dots in rats. J Surg Res 192:305–311

45.

Peng L, He M, Chen B, Wu Q, Zhang Z, Pang D, Zhu Y, Hu B (2013) Cellular uptake, elimination and toxicity of CdSe/ZnS quantum dots in HepG2 cells. Biomaterials 34:9545–9558PubMed

46.

Modlitbová P, Pořízka P, Novotný K, Drbohlavová J, Chamradová I, Farka Z, Zlámalová-Gargošová H, Romih T, Kaiser J (2018) Short-term assessment of cadmium toxicity and uptake from different types of Cd-based quantum dots in the model plant Allium cepa L. Ecotoxicol Environ Saf 153:23–31PubMed

47.

Chan WH, Shiao NH (2008) Cytotoxic effect of CdSe quantum dots on mouse embryonic development. Acta Pharmacol Sin 29:259–266PubMed

48.

Chu M, Wu Q, Yang H, Yuan R, Hou S, Yang Y, Zou Y, Xu S, Xu K, Ji A, Sheng L (2010) Transfer of quantum dots from pregnant mice to pups across the placental barrier. Small 6:670–678PubMed

49.

Pons T, Pic E, Lequeux N, Cassette E, Bezdetnaya L, Guillemin F, Marchal F, Dubertret B (2010) Cadmium-free CuInS2/ZnS quantum dots for sentinel lymph node imaging with reduced toxicity. ACS Nano 4:2531–2538PubMed

50.

Rizvi SB, Rouhi S, Taniguchi S et al (2014) Near-infrared quantum dots for HER2 localization and imaging of cancer cells. Int J Nanomedicine 9:1323–1337PubMedPubMedCentral

51.

Gao J, Chen K, Luong R, Bouley DM, Mao H, Qiao T, Gambhir SS, Cheng Z (2012) A novel clinically translatable fluorescent nanoparticle for targeted molecular imaging of tumors in living subjects. Nano Lett 12:281–286PubMed

52.

Lin G, Ouyang Q, Hu R, Ding Z, Tian J, Yin F, Xu G, Chen Q, Wang X, Yong KT (2015) In vivo toxicity assessment of non-cadmium quantum dots in BALB/c mice. Nanomedicine 11:341–350PubMed

53.

Zhang Y, Hong G, Chen G et al (2012) Ag2S quantum dot: a bright and biocompatible fluorescent nanoprobe in the second near-infrared window. ACS Nano 6:3695–3702PubMedPubMedCentral

54.

Zhang Y, Zhao N, Qin Y, Wu F, Xu Z, Lan T, Cheng Z, Zhao P, Liu H (2018) Affibody-functionalized Ag2S quantum dots for photoacoustic imaging of epidermal growth factor receptor overexpressed tumors. Nanoscale 10:16581–16590PubMed

55.

Zhang J, Yan J, Wang Y, Zhang Y (2018) One-step hydrothermal approach to synthesis carbon dots from D-sorbitol for detection of iron(III) and cell imaging. J Nanosci Nanotechnol 18:4457–4463PubMed

56.

Kaur H, Raj P, Sharma H, Verma M, Singh N, Kaur N (2018) Highly selective and sensitive fluorescence sensing of nanomolar Zn2+ ions in aqueous medium using calix[4]arene passivated carbon quantum dots based on fluorescence enhancement: real-time monitoring and intracellular investigation. Anal Chim Acta 1009:1–11PubMed

57.

Mollarasouli F, Serafín V, Campuzano S, Yáñez-Sedeño P, Pingarrón JM, Asadpour-Zeynali K (2018) Ultrasensitive determination of receptor tyrosine kinase with a label-free electrochemical immunosensor using graphene quantum dots-modified screen-printed electrodes. Anal Chim Acta 1011:28–34PubMed

58.

Nafiujjaman M, Joon H, Kwak KS, Lee YK (2018) Synthesis of nitrogen- and chlorine-doped graphene quantum dots for cancer cell imaging. J Nanosci Nanotechnol 18:3793–3799PubMed

59.

Zong S, Zong J, Chen C, Jiang X, Zhang Y, Wang Z, Cui Y (2018) Single molecule localization imaging of exosomes using blinking silicon quantum dots. Nanotechnology 29:065705PubMed

60.

Dohnalová K, Gregorkiewicz T, Kůsová K (2014) Silicon quantum dots: surface matters. J Phys Condens Matter 26:173201PubMed

61.

Liu H, Zhang X, Xing B (2010) Radiation-luminescence-excited quantum dots for in vivo multiplexed optical imaging. Small 6:1087–1091PubMed

Titel: Quantum Dot-Based Simultaneous Multicolor Imaging
verfasst von: Wenxia Wang
Zhen Liu
Xiaoli Lan
Publikationsdatum: 16.09.2019
Verlag: Springer International Publishing
Erschienen in: Molecular Imaging and Biology / Ausgabe 4/2020
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-019-01432-4

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Quantum Dot-Based Simultaneous Multicolor Imaging

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