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01.08.2020 | Neuro

Radiomics risk score may be a potential imaging biomarker for predicting survival in isocitrate dehydrogenase wild-type lower-grade gliomas

verfasst von: Chae Jung Park, Kyunghwa Han, Hwiyoung Kim, Sung Soo Ahn, Yoon Seong Choi, Yae Won Park, Jong Hee Chang, Se Hoon Kim, Rajan Jain, Seung-Koo Lee

Erschienen in: European Radiology | Ausgabe 12/2020

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Abstract

Objectives

Isocitrate dehydrogenase wild-type (IDHwt) lower-grade gliomas of histologic grades II and III follow heterogeneous clinical outcomes, which necessitates risk stratification. We aimed to evaluate whether radiomics from MRI would allow prediction of overall survival in patients with IDHwt lower-grade gliomas and to investigate the added prognostic value of radiomics over clinical features.

Methods

Preoperative MRIs of 117 patients with IDHwt lower-grade gliomas from January 2007 to February 2018 were retrospectively analyzed. The external validation cohort consisted of 33 patients from The Cancer Genome Atlas. A total of 182 radiomic features were extracted. Radiomics risk scores (RRSs) for overall survival were derived from the least absolute shrinkage and selection operator (LASSO) and elastic net. Multivariable Cox regression analyses, including clinical features and RRSs, were performed. The integrated areas under the receiver operating characteristic curves (iAUCs) from models with and without RRSs were calculated for comparisons. The prognostic value of RRS was assessed in the validation cohort.

Results

The RRS derived from LASSO and elastic net independently predicted survival with hazard ratios of 9.479 (95% confidence interval [CI], 3.220–27.847) and 6.148 (95% CI, 3.009–12.563), respectively. Those RRSs enhanced model performance for predicting overall survival (iAUC increased to 0.780–0.797 from 0.726), which was externally validated. The RRSs stratified IDHwt lower-grade gliomas in the validation cohort with significantly different survival.

Conclusion

Radiomics has the potential for noninvasive risk stratification and can improve prediction of overall survival in patients with IDHwt lower-grade gliomas when integrated with clinical features.

Key Points

• Isocitrate dehydrogenase wild-type lower-grade gliomas with histologic grades II and III follow heterogeneous clinical outcomes, which necessitates further risk stratification.

• Radiomics risk scores derived from MRI independently predict survival even after incorporating strong clinical prognostic features (hazard ratios 6.148–9.479).

• Radiomics risk scores derived from MRI have the potential to improve survival prediction when added to clinical features (integrated areas under the receiver operating characteristic curves increased from 0.726 to 0.780–0.797).

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Titel: Radiomics risk score may be a potential imaging biomarker for predicting survival in isocitrate dehydrogenase wild-type lower-grade gliomas
verfasst von: Chae Jung Park
Kyunghwa Han
Hwiyoung Kim
Sung Soo Ahn
Yoon Seong Choi
Yae Won Park
Jong Hee Chang
Se Hoon Kim
Rajan Jain
Seung-Koo Lee
Publikationsdatum: 01.08.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 12/2020
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-020-07089-w

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Radiomics risk score may be a potential imaging biomarker for predicting survival in isocitrate dehydrogenase wild-type lower-grade gliomas