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Journal of Neural Transmission

Erschienen in:

02.03.2016 | Translational Neurosciences - Short communication

Rasagiline prevents cyclosporine A-sensitive superoxide flashes induced by PK11195, the initial signal of mitochondrial membrane permeabilization and apoptosis

verfasst von: Yuqiu Wu, Masayo Shamoto-Nagai, Wakako Maruyama, Toshihiko Osawa, Makoto Naoi

Erschienen in: Journal of Neural Transmission | Ausgabe 5/2016

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Abstract

Rasagiline, a neuroprotective inhibitor of type B monoamine oxidase, prevented PK111195-induced apoptosis in SH-SY5Y cells through inhibition of mitochondrial apoptosis signaling (J Neural Transm 120:1539–1551, 2013, J Neural Transm 122:1399–1407, 2015). This paper presents that PK11195 induced superoxide flashes, the transit production burst, mediated by cyclosporine A-sensitive membrane permeability transition. Rasagiline prevented superoxide flashes, calcium efflux, and cell death by PK11195. Regulation of the initial pore formation at the inner mitochondrial membrane was confirmed as the decisive mechanism of neuroprotection by rasagiline.

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Titel: Rasagiline prevents cyclosporine A-sensitive superoxide flashes induced by PK11195, the initial signal of mitochondrial membrane permeabilization and apoptosis
verfasst von: Yuqiu Wu
Masayo Shamoto-Nagai
Wakako Maruyama
Toshihiko Osawa
Makoto Naoi
Publikationsdatum: 02.03.2016
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 5/2016
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-016-1531-8

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Rasagiline prevents cyclosporine A-sensitive superoxide flashes induced by PK11195, the initial signal of mitochondrial membrane permeabilization and apoptosis

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