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Erschienen in: Critical Care 1/2009

01.02.2009 | Commentary

Recombinant human activated protein C in acute lung injury: what is the role of bronchial circulation?

verfasst von: Marc O Maybauer, Daniel L Traber, Dirk M Maybauer

Erschienen in: Critical Care | Ausgabe 1/2009

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Abstract

Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Treatment with recombinant human activated protein C (rhAPC) has been reported to increase survival from severe sepsis. Protein C levels also decrease markedly in acute lung injury, of both septic and nonseptic origin. Low levels of protein C in acute lung injury are associated with poor clinical outcome. The present article discusses the beneficial effects of rhAPC in oleic acid-induced lung injury as well as the controversies between different animal models and the timing of drug administration. The unique bronchial circulation in ovine models seems to be responsible for the beneficial effects of rhAPC when given simultaneously to the injury.
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Metadaten
Titel
Recombinant human activated protein C in acute lung injury: what is the role of bronchial circulation?
verfasst von
Marc O Maybauer
Daniel L Traber
Dirk M Maybauer
Publikationsdatum
01.02.2009
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 1/2009
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc7155

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