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Erschienen in: Virchows Archiv 1/2007

01.01.2007 | Recommendation

Recommendations for the reporting of surgically resected specimens of colorectal carcinoma

verfasst von: Jeremy R. Jass, Michael J. O’Brien, Robert H. Riddell, Dale C. Snover

Erschienen in: Virchows Archiv | Ausgabe 1/2007

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Excerpt

The reporting of colorectal cancer is facilitated by the provision of a checklist giving the features required for good patient care. However, the practicalities of applying such a checklist may not be straightforward. Familiar examples include finding the prescribed number of lymph nodes, distinguishing mesenteric tumor deposits from replaced lymph nodes, and deciding if a cluster of malignant cells in a lymph node sinus counts as a metastasis. Checklists have traditionally focused on prognostic factors and particularly tumor stage. It is becoming increasingly clear that additional factors, whether morphological or molecular, will be needed for future clinical management. It is also evident that prognosis is strongly influenced by surgical technique, most notably by the introduction of total mesorectal excision in the case of rectal cancer. …
Literatur
1.
Zurück zum Zitat AJCC cancer staging manual (2002). Lipincott-Raven, Philadelphia AJCC cancer staging manual (2002). Lipincott-Raven, Philadelphia
2.
Zurück zum Zitat Baxter NN, Virnig DJ, Rothenberger DA, Morris AM, Jessurun J, Virnig BA (2005) Lymph node evaluation in colorectal cancer patients: a population-based study. J Natl Cancer Inst 97:219–225PubMed Baxter NN, Virnig DJ, Rothenberger DA, Morris AM, Jessurun J, Virnig BA (2005) Lymph node evaluation in colorectal cancer patients: a population-based study. J Natl Cancer Inst 97:219–225PubMed
3.
Zurück zum Zitat Bell SW, Mourra N, Flejou JF, Parc R, Tiret E (2005) Ex vivo sentinel lymph node mapping in colorectal cancer. Dis Colon Rectum 48:74–79PubMedCrossRef Bell SW, Mourra N, Flejou JF, Parc R, Tiret E (2005) Ex vivo sentinel lymph node mapping in colorectal cancer. Dis Colon Rectum 48:74–79PubMedCrossRef
4.
Zurück zum Zitat Berger AC, Sigurdson ER, LeVoyer T, Hanlon A, Mayer RJ, Macdonald JS, Catalano PJ, Haller DG (2005) Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes. J Clin Oncol 23:8706–8712PubMedCrossRef Berger AC, Sigurdson ER, LeVoyer T, Hanlon A, Mayer RJ, Macdonald JS, Catalano PJ, Haller DG (2005) Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes. J Clin Oncol 23:8706–8712PubMedCrossRef
5.
Zurück zum Zitat Cserni G (2002) Nodal staging of colorectal carcinomas and sentinel nodes. J Clin Pathol 56:327–335CrossRef Cserni G (2002) Nodal staging of colorectal carcinomas and sentinel nodes. J Clin Pathol 56:327–335CrossRef
6.
Zurück zum Zitat Doekhie FS, Peeters KCMJ, Kuppen PJK, Mesker WE, Tanke HJ, Morreau H, van de Velde CJH, Tollenaar RA (2005) The feasibility and reliability of sentinel node mapping in colorectal cancer. Eur J Surg Oncol 31:854–862PubMedCrossRef Doekhie FS, Peeters KCMJ, Kuppen PJK, Mesker WE, Tanke HJ, Morreau H, van de Velde CJH, Tollenaar RA (2005) The feasibility and reliability of sentinel node mapping in colorectal cancer. Eur J Surg Oncol 31:854–862PubMedCrossRef
7.
Zurück zum Zitat Dolcetti R, Viel A, Doglioni C, Russo A, Guidoboni M, Capozzi E, Vecchiato NEM, Fornasarig M, Boiocchi M (1999) High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability. Am J Pathol 154:1805–1813PubMed Dolcetti R, Viel A, Doglioni C, Russo A, Guidoboni M, Capozzi E, Vecchiato NEM, Fornasarig M, Boiocchi M (1999) High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability. Am J Pathol 154:1805–1813PubMed
8.
Zurück zum Zitat Fisher ER, Colangelo L, Wieand S, Fisher B, Wolmark N (2003) Lack of influence of cytokeratin-positive mini micrometastases in “negative node” patients with colorectal cancer: Findings from the National Surgical Adjuvant Breast and Bowel Projects protocols R-01 and C-01. Dis Colon Rectum 46:1021–1026PubMedCrossRef Fisher ER, Colangelo L, Wieand S, Fisher B, Wolmark N (2003) Lack of influence of cytokeratin-positive mini micrometastases in “negative node” patients with colorectal cancer: Findings from the National Surgical Adjuvant Breast and Bowel Projects protocols R-01 and C-01. Dis Colon Rectum 46:1021–1026PubMedCrossRef
9.
Zurück zum Zitat Goldstein NS (2002) Lymph node recoveries from 2427 pT3 colorectal resection specimens spanning 45 years: recommendations for a minimum number of recovered lymph nodes based on predictive probabilities. Am J Surg Pathol 26:179–189PubMedCrossRef Goldstein NS (2002) Lymph node recoveries from 2427 pT3 colorectal resection specimens spanning 45 years: recommendations for a minimum number of recovered lymph nodes based on predictive probabilities. Am J Surg Pathol 26:179–189PubMedCrossRef
10.
Zurück zum Zitat Goldstein NS, Turner JR (2000) Pericolonic tumor deposits in patients with T3N+MO colon adenocarcinomas. Markers of reduced disease free survival and intra-abdominal metastases and their implications for TNM classification. Cancer 88:2228–2238PubMedCrossRef Goldstein NS, Turner JR (2000) Pericolonic tumor deposits in patients with T3N+MO colon adenocarcinomas. Markers of reduced disease free survival and intra-abdominal metastases and their implications for TNM classification. Cancer 88:2228–2238PubMedCrossRef
11.
Zurück zum Zitat Gologan A, Krasinskas A, Hunt J, Thull DL, Farkas L, Sepulveda AR (2005) Performance of the revised Bethesda guidelines for identification of colorectal carcinomas with high level microsatellite instability. Arch Pathol Lab Med 129:1390–1397PubMed Gologan A, Krasinskas A, Hunt J, Thull DL, Farkas L, Sepulveda AR (2005) Performance of the revised Bethesda guidelines for identification of colorectal carcinomas with high level microsatellite instability. Arch Pathol Lab Med 129:1390–1397PubMed
12.
Zurück zum Zitat Greenson JK, Bonner JD, Ben-Yzhak O, Cohen HI, Miselvich I, Resnick MB, Trougouboff P, Tomsho LD, Kim E, low M et al (2003) Phenotype of microsatellite unstable colorectal carcinomas. Am J Surg Pathol 27:563–570PubMedCrossRef Greenson JK, Bonner JD, Ben-Yzhak O, Cohen HI, Miselvich I, Resnick MB, Trougouboff P, Tomsho LD, Kim E, low M et al (2003) Phenotype of microsatellite unstable colorectal carcinomas. Am J Surg Pathol 27:563–570PubMedCrossRef
13.
Zurück zum Zitat Greenson JK, Isenhart CE, Rice R, Mojzisik C, Houchens D, Martin EWJ (1994) Identification of occult micrometastases in pericolic lymph nodes of Dukes’ B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Correlation with long-term survival. Cancer 73:563–569PubMedCrossRef Greenson JK, Isenhart CE, Rice R, Mojzisik C, Houchens D, Martin EWJ (1994) Identification of occult micrometastases in pericolic lymph nodes of Dukes’ B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Correlation with long-term survival. Cancer 73:563–569PubMedCrossRef
14.
Zurück zum Zitat Hamilton SR, Aaltonen LA (2000) World Health Organization classification of tumours. Pathology and genetics. IARC, Lyon Hamilton SR, Aaltonen LA (2000) World Health Organization classification of tumours. Pathology and genetics. IARC, Lyon
15.
Zurück zum Zitat Hase K, Shatney C, Johnson D, Trollope M, Vierra M (1993) Prognostic value of tumor “budding” in patients with colorectal cancer. Dis Colon Rectum 36:627–635PubMedCrossRef Hase K, Shatney C, Johnson D, Trollope M, Vierra M (1993) Prognostic value of tumor “budding” in patients with colorectal cancer. Dis Colon Rectum 36:627–635PubMedCrossRef
16.
Zurück zum Zitat Hori H, Fujimori T, Fujii S, Ichikawa K, Ohkura Y, Tomita S, Ono Y, Imura J, Kuroda Y (2005) Evaluation of tumor cell dissociation as a predictive marker of lymph node metastasis in submucosal invasive colorectal carcinoma. Dis Colon Rectum 48:938–945PubMedCrossRef Hori H, Fujimori T, Fujii S, Ichikawa K, Ohkura Y, Tomita S, Ono Y, Imura J, Kuroda Y (2005) Evaluation of tumor cell dissociation as a predictive marker of lymph node metastasis in submucosal invasive colorectal carcinoma. Dis Colon Rectum 48:938–945PubMedCrossRef
17.
Zurück zum Zitat Howarth SM, Morgan JM, Williams GT (2004) The new (6th edition) TNM classification of colorectal cancer—a stage too far. Gut 53:A81 Howarth SM, Morgan JM, Williams GT (2004) The new (6th edition) TNM classification of colorectal cancer—a stage too far. Gut 53:A81
18.
Zurück zum Zitat Jass JR (2005) Serrated adenoma of the colorectum and the DNA-methylator phenotype. Nat Clin Pract Oncol 2:398–405PubMedCrossRef Jass JR (2005) Serrated adenoma of the colorectum and the DNA-methylator phenotype. Nat Clin Pract Oncol 2:398–405PubMedCrossRef
19.
Zurück zum Zitat Jass JR, Ajioka Y, Allen JP, Chan YF, Cohen RJ, Nixon JM, Radojkovic M, Restall AP, Stables SR, Zwi LJ (1996) Assessment of invasive growth pattern and lymphocytic infiltration in colorectal cancer. Histopathology 28:543–548PubMedCrossRef Jass JR, Ajioka Y, Allen JP, Chan YF, Cohen RJ, Nixon JM, Radojkovic M, Restall AP, Stables SR, Zwi LJ (1996) Assessment of invasive growth pattern and lymphocytic infiltration in colorectal cancer. Histopathology 28:543–548PubMedCrossRef
20.
Zurück zum Zitat Jass JR, Atkin WS, Cuzick J, Bussey HJR, Morson BC, Northover JMN, Todd IP (1986) The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology 10:437–459PubMed Jass JR, Atkin WS, Cuzick J, Bussey HJR, Morson BC, Northover JMN, Todd IP (1986) The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology 10:437–459PubMed
21.
Zurück zum Zitat Jass JR, Do K-A, Simms LA, Iino H, Wynter C, Pillay SP, Searle J, Radford-Smith G, Young J, Leggett B (1998) Morphology of sporadic colorectal cancer with DNA replication errors. Gut 42:673–679PubMedCrossRef Jass JR, Do K-A, Simms LA, Iino H, Wynter C, Pillay SP, Searle J, Radford-Smith G, Young J, Leggett B (1998) Morphology of sporadic colorectal cancer with DNA replication errors. Gut 42:673–679PubMedCrossRef
22.
Zurück zum Zitat Jass JR, Love SB (1989) Prognostic value of direct spread in Dukes’ C cases of rectal cancer. Dis Colon Rectum 32:477–480PubMedCrossRef Jass JR, Love SB (1989) Prognostic value of direct spread in Dukes’ C cases of rectal cancer. Dis Colon Rectum 32:477–480PubMedCrossRef
23.
Zurück zum Zitat Jass JR, Love SB, Northover JMA (1987) A new prognostic classification of rectal cancer. Lancet 1:1303–1306PubMedCrossRef Jass JR, Love SB, Northover JMA (1987) A new prognostic classification of rectal cancer. Lancet 1:1303–1306PubMedCrossRef
24.
Zurück zum Zitat Jass JR, Morson BC (1987) Reporting colorectal cancer. J Clin Pathol 40:1016–1023PubMed Jass JR, Morson BC (1987) Reporting colorectal cancer. J Clin Pathol 40:1016–1023PubMed
25.
Zurück zum Zitat Kazama S, Watanabe T, Ajioka Y, Kanazawa H, Nagawa H (2006) Tumour budding at the deepest invasive margin correlates with lymph node metastasis in submucosal cancer detected by anticytokeratin antibody CAM5.2. Br J Cancer 94:293–298PubMedCrossRef Kazama S, Watanabe T, Ajioka Y, Kanazawa H, Nagawa H (2006) Tumour budding at the deepest invasive margin correlates with lymph node metastasis in submucosal cancer detected by anticytokeratin antibody CAM5.2. Br J Cancer 94:293–298PubMedCrossRef
26.
Zurück zum Zitat Merkel S, Mansmann U, Siassi M, Papadopoulos T, Hohenberger W, Hermanek P (2001) The prognostic inhomogeneity in pT3 rectal carcinomas. Int J Colorect Dis 16:298–304CrossRef Merkel S, Mansmann U, Siassi M, Papadopoulos T, Hohenberger W, Hermanek P (2001) The prognostic inhomogeneity in pT3 rectal carcinomas. Int J Colorect Dis 16:298–304CrossRef
27.
Zurück zum Zitat Morodomi T, Isomoto H, Shirouzu K, Kakegawa K, Irie K, Morimatsu M (1989) An index for estimating the probability of lymph node metastasis in rectal cancers. Lymph node metastasis and the histopathology of actively invasive regions of cancer. Cancer 63:539–543PubMedCrossRef Morodomi T, Isomoto H, Shirouzu K, Kakegawa K, Irie K, Morimatsu M (1989) An index for estimating the probability of lymph node metastasis in rectal cancers. Lymph node metastasis and the histopathology of actively invasive regions of cancer. Cancer 63:539–543PubMedCrossRef
28.
Zurück zum Zitat Nagtegaal ID, Marijnen CAM, Kranenbarg EK, Mulder-Stapel A, Hermans J, van de Velde CJH, van Krieken JHJM (2002) Short-term preoperative radiotherapy interferes with the determination of pathological parameters in rectal cancer. J Pathol 197:20–27PubMedCrossRef Nagtegaal ID, Marijnen CAM, Kranenbarg EK, Mulder-Stapel A, Hermans J, van de Velde CJH, van Krieken JHJM (2002) Short-term preoperative radiotherapy interferes with the determination of pathological parameters in rectal cancer. J Pathol 197:20–27PubMedCrossRef
29.
Zurück zum Zitat Nagtegaal ID, Marijnen CAM, Kranenbarg EK, van de Velde CJH, van Krieken JHJM (2002) Circumferential margin involvement is still important predictor of local recurrence in rectal carcinoma. Not one millimeter but two millimeters is the limit. Am J Surg Pathol 26:350–357PubMedCrossRef Nagtegaal ID, Marijnen CAM, Kranenbarg EK, van de Velde CJH, van Krieken JHJM (2002) Circumferential margin involvement is still important predictor of local recurrence in rectal carcinoma. Not one millimeter but two millimeters is the limit. Am J Surg Pathol 26:350–357PubMedCrossRef
30.
Zurück zum Zitat Nagtegaal ID, van de Velde CJH, van der Worp E, Kapiteijn E, Quirke P, van Krieken JH (2002) Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control. J Clin Oncol 20:1729–1734PubMedCrossRef Nagtegaal ID, van de Velde CJH, van der Worp E, Kapiteijn E, Quirke P, van Krieken JH (2002) Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control. J Clin Oncol 20:1729–1734PubMedCrossRef
31.
Zurück zum Zitat Nascimbeni R, Burgart LJ, Nivatvongs S, Larson DR (2002) Risk of lymph node metastasis in T1 carcinoma of the colon and rectum. Dis Colon Rectum 45:200–206PubMedCrossRef Nascimbeni R, Burgart LJ, Nivatvongs S, Larson DR (2002) Risk of lymph node metastasis in T1 carcinoma of the colon and rectum. Dis Colon Rectum 45:200–206PubMedCrossRef
32.
Zurück zum Zitat Newland RC, Chapuis PH, Smyth EJ (1987) The prognostic value of substaging colorectal carcinoma. A prospective study of 1,117 cases with standardized pathology. Cancer 60:852–857PubMedCrossRef Newland RC, Chapuis PH, Smyth EJ (1987) The prognostic value of substaging colorectal carcinoma. A prospective study of 1,117 cases with standardized pathology. Cancer 60:852–857PubMedCrossRef
33.
Zurück zum Zitat Newland RC, Dent OF, Chapuis PH, Bokey L (1995) Survival after curative resection of lymph node negative colorectal carcinoma: a prospective study of 910 patients. Cancer 76:564–571PubMedCrossRef Newland RC, Dent OF, Chapuis PH, Bokey L (1995) Survival after curative resection of lymph node negative colorectal carcinoma: a prospective study of 910 patients. Cancer 76:564–571PubMedCrossRef
34.
Zurück zum Zitat O’Connell JB, Maggard MA, Ko CY (2004) Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst 96:1420–1425PubMedCrossRef O’Connell JB, Maggard MA, Ko CY (2004) Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst 96:1420–1425PubMedCrossRef
35.
Zurück zum Zitat Petersen VC, Baxter KJ, Love SB, Shepherd NA (2002) Identification of objective pathological prognostic determinants and models of prognosis in Dukes’ B colon cancer. Gut 51:65–69PubMedCrossRef Petersen VC, Baxter KJ, Love SB, Shepherd NA (2002) Identification of objective pathological prognostic determinants and models of prognosis in Dukes’ B colon cancer. Gut 51:65–69PubMedCrossRef
36.
Zurück zum Zitat Quirke P (2003) Training and quality assurance for rectal cancer: 20 years of data is enough. Lancet Oncol 4:695–702PubMedCrossRef Quirke P (2003) Training and quality assurance for rectal cancer: 20 years of data is enough. Lancet Oncol 4:695–702PubMedCrossRef
37.
Zurück zum Zitat Quirke P, Durdey P, Dixon MF, Williams NS (1986) Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet 2:996–999PubMedCrossRef Quirke P, Durdey P, Dixon MF, Williams NS (1986) Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet 2:996–999PubMedCrossRef
38.
Zurück zum Zitat Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma V-M (1997) Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J Pathol 182:318–324PubMedCrossRef Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma V-M (1997) Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J Pathol 182:318–324PubMedCrossRef
39.
Zurück zum Zitat Ryan R, Gibbons D, Hyland JMP, Treanor D, White A, Mulcahy HE, O’Donoghue DP, Moriarty M, Fennely D, Sheahan K (2005) Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Histopathology 47:141–146PubMedCrossRef Ryan R, Gibbons D, Hyland JMP, Treanor D, White A, Mulcahy HE, O’Donoghue DP, Moriarty M, Fennely D, Sheahan K (2005) Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Histopathology 47:141–146PubMedCrossRef
40.
Zurück zum Zitat Saha S, Dan AG, Viehl CT, Zuber M, Wiese D (2005) Sentinel lymph node mapping in colon and rectal cancer: its impact on staging, limitations, and pitfalls. Cancer Treat Res 127:105–122PubMedCrossRef Saha S, Dan AG, Viehl CT, Zuber M, Wiese D (2005) Sentinel lymph node mapping in colon and rectal cancer: its impact on staging, limitations, and pitfalls. Cancer Treat Res 127:105–122PubMedCrossRef
41.
Zurück zum Zitat Sarli L, Bader G, Iusco D, Salvemini C, Mauro DD, Mazzeo A, Regina G, Roncoroni L (2005) Number of lymph nodes examined and prognosis of TNM stage II colorectal cancer. Eur J Cancer 41:272–279PubMedCrossRef Sarli L, Bader G, Iusco D, Salvemini C, Mauro DD, Mazzeo A, Regina G, Roncoroni L (2005) Number of lymph nodes examined and prognosis of TNM stage II colorectal cancer. Eur J Cancer 41:272–279PubMedCrossRef
42.
Zurück zum Zitat Shepherd NA, Baxter KJ, Love SB (1995) Influence of local peritoneal involvement on pelvic recurrence and prognosis in rectal cancer. J Clin Pathol 48:849–855PubMed Shepherd NA, Baxter KJ, Love SB (1995) Influence of local peritoneal involvement on pelvic recurrence and prognosis in rectal cancer. J Clin Pathol 48:849–855PubMed
43.
Zurück zum Zitat Shepherd NA, Baxter KR, Love SB (1997) The prognostic importance of peritoneal involvement in colonic cancer: a prospective evaluation. Gastroenterology 112:1096–1102PubMedCrossRef Shepherd NA, Baxter KR, Love SB (1997) The prognostic importance of peritoneal involvement in colonic cancer: a prospective evaluation. Gastroenterology 112:1096–1102PubMedCrossRef
44.
Zurück zum Zitat Shinto E, Mochizuki H, Ueno H, Matsubara O, Jass JR (2005) A novel classification of tumour budding in colorectal cancer based on the presence of cytoplasmic pseudo-fragments around budding foci. Histopathology 47:25–31PubMedCrossRef Shinto E, Mochizuki H, Ueno H, Matsubara O, Jass JR (2005) A novel classification of tumour budding in colorectal cancer based on the presence of cytoplasmic pseudo-fragments around budding foci. Histopathology 47:25–31PubMedCrossRef
45.
Zurück zum Zitat Smyrk TC, Watson P, Kaul K, Lynch HT (2001) Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal cancer. Cancer 91:2417–2422PubMedCrossRef Smyrk TC, Watson P, Kaul K, Lynch HT (2001) Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal cancer. Cancer 91:2417–2422PubMedCrossRef
46.
Zurück zum Zitat Sobin LH, Wittekind C (1997) TNM Classification of malignant tumours. Wiley-Liss, New York Sobin LH, Wittekind C (1997) TNM Classification of malignant tumours. Wiley-Liss, New York
47.
Zurück zum Zitat Sobin LH, Wittekind C (2002) TNM Classification of malignant tumours. Wiley-Liss, New York Sobin LH, Wittekind C (2002) TNM Classification of malignant tumours. Wiley-Liss, New York
48.
Zurück zum Zitat Talbot IC, Ritchie S, Leighton M, Hughes AO, Bussey HJ, Morson BC (1981) Invasion of veins by carcinoma of rectum: method of detection, histological features and significance. Histopathology 5:141–163PubMed Talbot IC, Ritchie S, Leighton M, Hughes AO, Bussey HJ, Morson BC (1981) Invasion of veins by carcinoma of rectum: method of detection, histological features and significance. Histopathology 5:141–163PubMed
49.
Zurück zum Zitat Talbot IC, Ritchie S, Leighton MH, Hughes AO, Busey HJ, Morson BC (1981) Spread of rectal cancer within veins. Histologic features and clinical significance. Histopathology 5:141–163PubMed Talbot IC, Ritchie S, Leighton MH, Hughes AO, Busey HJ, Morson BC (1981) Spread of rectal cancer within veins. Histologic features and clinical significance. Histopathology 5:141–163PubMed
50.
Zurück zum Zitat Ueno H, Murphy J, Jass JR, Mochizuki H, Talbot IC (2002) Tumour ‘budding’ as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology 40:127–132PubMedCrossRef Ueno H, Murphy J, Jass JR, Mochizuki H, Talbot IC (2002) Tumour ‘budding’ as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology 40:127–132PubMedCrossRef
51.
Zurück zum Zitat Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Ruschoff J, Fishel R, Lindor NM, Burgart LJ, Hamelin R et al (2004) Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96:261–268PubMedCrossRef Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Ruschoff J, Fishel R, Lindor NM, Burgart LJ, Hamelin R et al (2004) Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96:261–268PubMedCrossRef
52.
Zurück zum Zitat van Wyk Q, Hosie KB, Balsitis M (2000) Histopathological detection of lymph node metastases from colorectal carcinoma. J Clin Pathol 53:685–687PubMedCrossRef van Wyk Q, Hosie KB, Balsitis M (2000) Histopathological detection of lymph node metastases from colorectal carcinoma. J Clin Pathol 53:685–687PubMedCrossRef
53.
Zurück zum Zitat Verrill C, Carr NJ, Wilkinson-Smith E, Seel EH (2004) Histopathological assessment of lymph nodes in colorectal carcinoma: does triple levelling detect significantly more metastases? J Clin Pathol 57:1165–1167PubMedCrossRef Verrill C, Carr NJ, Wilkinson-Smith E, Seel EH (2004) Histopathological assessment of lymph nodes in colorectal carcinoma: does triple levelling detect significantly more metastases? J Clin Pathol 57:1165–1167PubMedCrossRef
54.
Zurück zum Zitat Wheeler JMD, Warren BF, Jones AC, Mortensen NJM (1999) Preoperative radiotherapy for rectal cancer: implications for surgeons, pathologists and radiologists. Br J Surg 86:1108–1120PubMedCrossRef Wheeler JMD, Warren BF, Jones AC, Mortensen NJM (1999) Preoperative radiotherapy for rectal cancer: implications for surgeons, pathologists and radiologists. Br J Surg 86:1108–1120PubMedCrossRef
55.
Zurück zum Zitat Wittekind C, Greene FL, Henson DE, Hutter RVP, Sobin LH (2003) TNM Supplement. A commentary on uniform use. Wiley-Liss, New York Wittekind C, Greene FL, Henson DE, Hutter RVP, Sobin LH (2003) TNM Supplement. A commentary on uniform use. Wiley-Liss, New York
56.
Zurück zum Zitat Wright FC, Law CHL, Last L, Khalifa M, Arnaout A, Naseer Z, Klar N, Gallinger S, Smith AJ (2003) Lymph node retrieval and assessment in stage II colorectal cancer: a population-based study. Ann Surg Oncol 10:903–909PubMedCrossRef Wright FC, Law CHL, Last L, Khalifa M, Arnaout A, Naseer Z, Klar N, Gallinger S, Smith AJ (2003) Lymph node retrieval and assessment in stage II colorectal cancer: a population-based study. Ann Surg Oncol 10:903–909PubMedCrossRef
Metadaten
Titel
Recommendations for the reporting of surgically resected specimens of colorectal carcinoma
verfasst von
Jeremy R. Jass
Michael J. O’Brien
Robert H. Riddell
Dale C. Snover
Publikationsdatum
01.01.2007
Verlag
Springer-Verlag
Erschienen in
Virchows Archiv / Ausgabe 1/2007
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-006-0302-6

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