The online version of this article (doi:10.1186/1475-2840-11-38) contains supplementary material, which is available to authorized users.
Chang-Hee Kwon, Eun-Jung Rhee contributed equally to this work.
The authors declare that they have no competing interests.
CK and ER analyzed the data, drafted the manuscript and revised the manuscript. JS and JK commented on the revision of the manuscript. KS designed the study, collected and analyzed the data. All authors have given their final approval for publication of this version of the manuscript.
Reduced lung function is associated with incident insulin resistance and diabetes. The aim of this study was to assess the relationship between lung function and incident type 2 diabetes in Korean men.
This study included 9,220 men (mean age: 41.4 years) without type 2 diabetes at baseline who were followed for five years. Subjects were divided into four groups according to baseline forced vital capacity (FVC) (% predicted) and forced expiratory volume in one second (FEV1) (% predicted) quartiles. The incidence of type 2 diabetes at follow-up was compared according to FVC and FEV1 quartiles.
The overall incidence of type 2 diabetes was 2.2%. Reduced lung function was significantly associated with the incidence of type 2 diabetes after adjusting for age, BMI, education, smoking, exercise, alcohol, and HOMA-IR. Both FVC and FEV1 were negatively associated with type 2 diabetes (P < 0.05). In non-obese subjects with BMI < 25, the lowest quartile of FVC and FEV1 had a significantly higher odds ratio for type 2 diabetes compared with the highest quartile after adjusting for age and BMI (2.15 [95% CI 1.02-4.57] and 2.19 [95% CI 1.09-4.42]).
Reduced lung function is independently associated with the incidence of type 2 diabetes in Korean men.
Authors’ original file for figure 112933_2012_499_MOESM1_ESM.pdf
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- Reduced lung function is independently associated with increased risk of type 2 diabetes in Korean men
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