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13.08.2016 | Original Contribution

Relationship between soluble receptor for advanced glycation end products (sRAGE), body composition and fat distribution in healthy women

verfasst von: Elena Dozio, Silvia Briganti, Alessandra Delnevo, Elena Vianello, Federica Ermetici, Francesco Secchi, Francesco Sardanelli, Lelio Morricone, Alexis E. Malavazos, Massimiliano M. Corsi Romanelli

Erschienen in: European Journal of Nutrition | Ausgabe 8/2017

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Abstract

Purpose

Soluble receptor for advanced glycation end products (sRAGE) is a decoy receptor which sequesters RAGE ligands and acts as a cytoprotective agent. To date, it is unclear whether the lower sRAGE levels observed in obesity are a marker of increased overall adiposity or reflect increases in particular fat depots. Therefore, we evaluated in healthy women the relationship among sRAGE and indicators of adiposity, including abdominal visceral (VAT) and epicardial visceral (EAT) adipose tissues, to explore the potential role of sRAGE as an earlier biomarker of cardiometabolic risk.

Methods

Plasma sRAGE levels were quantified by an enzyme-linked immunosorbent assay in 47 healthy women. Total fat mass (FM) and fat-free mass were estimated with bioimpedance analysis. Anthropometric measures and biochemical data were recorded. Subcutaneous adipose tissue, VAT and EAT volumes were measured by magnetic resonance imaging.

Results

Obese women had lower sRAGE levels compared to normal-weight women. sRAGE levels were also lower in women with a waist circumference (WC) larger than 80 cm. Correlation analyses indicated an inverse association of sRAGE with body mass index and FM. Concerning adipose tissue distribution, sRAGE inversely correlated with WC, EAT and VAT depots. In a multiple stepwise regression analysis, performed to emphasize the role of fat distribution, EAT volume was the only predictor of sRAGE.

Conclusions

Lower sRAGE levels reflect accumulation of visceral fat mainly at the epicardial level and are present in advance of metabolic complications in adult women. sRAGE quantification might be an early marker of cardiometabolic risk.

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Titel: Relationship between soluble receptor for advanced glycation end products (sRAGE), body composition and fat distribution in healthy women
verfasst von: Elena Dozio
Silvia Briganti
Alessandra Delnevo
Elena Vianello
Federica Ermetici
Francesco Secchi
Francesco Sardanelli
Lelio Morricone
Alexis E. Malavazos
Massimiliano M. Corsi Romanelli
Publikationsdatum: 13.08.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 8/2017
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-016-1291-0

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Relationship between soluble receptor for advanced glycation end products (sRAGE), body composition and fat distribution in healthy women

Abstract

Purpose

Methods

Results

Conclusions

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