Erschienen in:
12.11.2015 | Originalien
Relationship of osteoprotegerin to pulse wave velocity and
carotid intima-media thickness in rheumatoid arthritis patients
verfasst von:
M.S. Beyazal, MD, T. Erdoğan, G. Devrimsel, A.K. Türkyılmaz, M.C. Cüre, M. Beyazal, I. Sahin
Erschienen in:
Zeitschrift für Rheumatologie
|
Ausgabe 7/2016
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Abstract
Objective
Osteoprotegerin (OPG) is considered an important biomarker in cardiovascular
(CV) disease. CV disease is the most common cause of mortality in patients with
rheumatoid arthritis (RA), a consequence of accelerated atherosclerosis. The
present study aimed to evaluate the relationship of serum OPG levels to arterial
stiffness, carotid intima-media thickness (CIMT), and clinical and laboratory
indices in RA patients.
Patients and methods
Included in the study were 68 RA patients with no history or signs of CV
disease and 48 healthy subjects Disease activity was assessed by the 28-joint
disease activity score (DAS28) in RA patients. Serum OPG level was measured
using enzyme-linked immunosorbent assay (ELISA). Carotid femoral pulse wave
velocity (PWV) was measured as an index of arterial stiffness and CIMT was
evaluated by carotid ultrasonography.
Results
The mean serum OPG level was significantly higher in RA patients than controls
(p < 0.001). Mean PWV and CIMT were also significantly increased in RA
patients compared to controls (both p < 0.001). In RA patients, serum OPG
level was significantly correlated with PWV and CIMT, as well as rheumatoid
factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody; but not
with DAS28, high-sensitivity C-reactive protein (hsCRP), or erythrocyte
sedimentation rate.
Conclusion
Serum OPG levels were increased and correlated with CIMT and PWV in RA
patients. In addition to PWV and CIMT, OPG may be a useful biomarker for CV risk
management in RA patients.