Introduction
Methods
Design and study population
Blood pressure assessments
Other assessments
RDN procedure
Statistical analysis
Results
Baseline characteristics
All patients (n = 53) | |
---|---|
Age (years)a
| 62 (35–80) |
Gender (male)b
| 24 (45.3) |
Caucasianb
| 53 (100) |
Body mass index | 28.4 (±4.9) |
Comorbidity | |
Dyslipidemiab
| 36 % |
Diabetes Mellitus type 2b
| 11 % |
Cardiovascular diseasesb
| 15 % |
Cerebrovascular diseasesb
| 6 % |
Current smokingb
| 4 (8) |
Nr. of antihypertensive drugsa
| 0 (0–0) |
Reason for no medication use | |
Intolerance, unknownb
| 30 (57) |
Study purposesb
| 15 (28) |
Never prescribedb
| 8 (15) |
Office blood pressure | |
Systolic (mmHg) | 180 (±24) |
Diastolic (mmHg) | 101 (±14) |
Heart rate (bpm) | 72 (±10) |
Ambulatory blood pressure | |
24-h systolic (mmHg) | 160 (±17) |
24-h diastolic (mmHg) | 94 (±11) |
24-h heart rate (bpm) | 72 (±9) |
eGFR, CKD epi (mL/min/1.73 m2) | 85 (±18) |
Presence of accessory renal arteriesb
| 13 (25) |
Not all renal arteries treatedb
| 7 (15) |
Device used | |
Symplicityb
| 42 (79) |
EnligHTNb
| 10 (19) |
PARADISEb
| 1 (2) |
Nr. of ablationsa
| 13 (2–25) |
Change in blood pressure
N
| Mean change compared to baseline (95 % CI) | |
---|---|---|
Ambulatory blood pressure | ||
24-h systolic (mmHg) | 43 | −5.7 (−11.0 to −0.4) |
24-h diastolic (mmHg) | 43 | −4.0 (−6.6 to −1.4) |
24-h heart rate (bpm) | 35 | −1.1 (−3.8 to 1.7) |
Day-time systolic (mmHg) | 39 | −8.2 (−13.4 to −3.0) |
Day-time diastolic (mmHg) | 39 | −4.9 (−7.9 to −2.5) |
Nighttime systolic (mmHg) | 38 | −6.3 (−14.1 to 1.4) |
Nighttime diastolic (mmHg) | 38 | −4.8 (−9.9 to 0.4) |
Office blood pressure | ||
Systolic (mmHg) | 47 | −13.1 (−20.4 to −5.7) |
Diastolic (mmHg) | 47 | −4.4 (−7.8 to −1.1) |
Heart rate (bpm) | 25 | −2.6 (−6.7 to 1.5) |
Body mass index (kg/m2) | 25 | 0.5 (−0.9 to 1.9) |
eGFR, CKD epi (mL/min/1.73 m2) | 48 | 0.4 (−1.9 to 2.8) |
Urinary sodium excretion (mmol/24 h) | 16 | −23.3 (−89.3 to 42.7) |
Anatomic and procedural determinants
Explorative analyses into determinants of response to RDN
N
| B (95 % CI) | |
---|---|---|
Age | 43 | 0.19 (−0.39 to 0.76) |
Gender, female | 43 | 1.58a (−9.23 to 12.38) |
Body mass index | 40 | 0.52 (−0.53 to 1.58) |
eGFR, CDK epi (mL/min/1.73 m2) | 40 | −0.13 (−0.45 to 0.18) |
Urine sodium mmol/24 h | 24 | 0.01 (−0.05 to 0.07) |
Baseline 24-h SBP (mmHg) | 43 | −0.22 (−0.53 to 0.08) |
Baseline percentage dipping | 38 | 0.76 (0.18 to 1.35) |
Baseline nighttime SBP (mmHg) | 38 | −0.43 (−0.70 to −0.16) |
Nr. of ablations | 40 | −0.03 (−1.75 to 1.69) |