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Endocrine Pathology

Erschienen in:

01.05.2007

RET Signaling in Endocrine Tumors: Delving Deeper into Molecular Mechanisms

verfasst von: Andrea Z. Lai, Taranjit S. Gujral, Lois M. Mulligan

Erschienen in: Endocrine Pathology | Ausgabe 2/2007

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Abstract

The rearranged during transfection (RET) proto-oncogene encodes a receptor tyrosine kinase that is implicated in the development of endocrine tumors of the thyroid and adrenal glands. In humans, activating RET mutations are found in the inherited cancer syndrome multiple endocrine neoplasia 2 and in sporadic medullary and papillary thyroid carcinomas. The specific type and location of RET mutations are strongly correlated with the disease phenotype and have both diagnostic and prognostic value. Recent advances in the molecular characterization of the RET receptor and its mutants have begun to define the mechanisms underlying the transforming ability of the different RET mutant forms. This information has revealed key functional features of these mutant proteins that distinguish the different clinically recognized mutations and provide clues as to the functional origins of the phenotypes associated with specific RET mutations. The elucidation of molecular mechanisms involved in RET-mediated transformation is a key step in the development of much needed therapeutics that target RET’s oncogenic properties. Recent advances have begun to provide a deeper understanding of the receptor’s function, and dysfunction, in human tumors that may guide this process.

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Titel: RET Signaling in Endocrine Tumors: Delving Deeper into Molecular Mechanisms
verfasst von: Andrea Z. Lai
Taranjit S. Gujral
Lois M. Mulligan
Publikationsdatum: 01.05.2007
Verlag: Humana Press Inc
Erschienen in: Endocrine Pathology / Ausgabe 2/2007
Print ISSN: 1046-3976
Elektronische ISSN: 1559-0097
DOI: https://doi.org/10.1007/s12022-007-0009-5

Springer Medizin

RET Signaling in Endocrine Tumors: Delving Deeper into Molecular Mechanisms

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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