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Erschienen in: Journal of Experimental & Clinical Cancer Research 1/2021

Open Access 01.12.2021 | Retraction Note

Retraction Note: MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance

verfasst von: Shan Zhou, Jinping Lu, Yuejin Li, Chan Chen, Yongqiang Cai, Gongjun Tan, Zhengke Peng, Zhenlin Zhang, Zigang Dong, Tiebang Kang, Faqing Tang

Erschienen in: Journal of Experimental & Clinical Cancer Research | Ausgabe 1/2021

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Shan Zhou, Jinping Lu and Yuejin Li contributed equally to this work.
The original article can be found online at https://​doi.​org/​10.​1186/​s13046-018-0956-3.

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Retraction Note: J Exp Clin Cancer Res 37, 284 (2018)
https://doi.org/10.1186/s13046-018-0956-3
The Editor-in-Chief has retracted this article at the request of the authors. After publication, concerns were raised about the data presented in Fig. 8c having been published elsewhere representing different samples [15]. The authors checked their data and noticed that inaccurate results were presented in Fig. 1B, 3F and 5E. Further investigation revealed the following additional issues:
  • In Fig. 4D, the background of parts of the Flag bands appears completely smooth, as if parts of the image have been removed.
  • In Fig. 5E (right panel), there is a noticeable break in the background of the blot, and the two parts are misaligned in the image.
  • In Fig. 6C,
    • ○ the image of the bands presented for MNAT1 (LoVo cells) appears highly similar to that in Fig. 2D DLD1 cells;
    • ○ MDM2 and MNAT1 and HSP60 (HEK293T cells) appear highly similar to Fig. 2A MNAT1 and GAPDH (HCT116 cells);
    • ○ p53 (LoVo cells) bands apprat highly similar to those presented for MNAT1 in Fig. 6D.
  • In Fig. 7A, the GAPDH bands appear highly similar to the HSP70 bands in Fig. 3A-b.
The data reported in this article are therefore unreliable. In addition, the authors were unable to provide a copy of the original Ethics Approval for the animal study upon the Editor's request, which raises further concerns about the integrity of the article.
None of the authors have responded to any correspondence from the editor or publisher about this retraction.
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://​creativecommons.​org/​licenses/​by/​4.​0/​. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Zurück zum Zitat Tan G, Tang X, Huang D, Li Y, Liu N, Peng Z, et al. Dinitrosopiperazine-mediated phosphorylated-proteins are involved in nasopharyngeal carcinoma metastasis. International Journal of Molecular Sciences. 2014;15:20054–71.CrossRef Tan G, Tang X, Huang D, Li Y, Liu N, Peng Z, et al. Dinitrosopiperazine-mediated phosphorylated-proteins are involved in nasopharyngeal carcinoma metastasis. International Journal of Molecular Sciences. 2014;15:20054–71.CrossRef
Metadaten
Titel
Retraction Note: MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance
verfasst von
Shan Zhou
Jinping Lu
Yuejin Li
Chan Chen
Yongqiang Cai
Gongjun Tan
Zhengke Peng
Zhenlin Zhang
Zigang Dong
Tiebang Kang
Faqing Tang
Publikationsdatum
01.12.2021
Verlag
BioMed Central
Erschienen in
Journal of Experimental & Clinical Cancer Research / Ausgabe 1/2021
Elektronische ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-021-02204-1

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