Skip to main content
Erschienen in: International Ophthalmology 4/2021

02.01.2021 | Original Paper

Retrospective investigation of peripheric blood sampling in pediatric chalazion patients

verfasst von: Cagri Ilhan

Erschienen in: International Ophthalmology | Ausgabe 4/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To compare serum thyroid hormone, vitamin B12, vitamin D3, folic acid, and ferritin levels between pediatric chalazion patients and healthy children.

Methods

Under 18-year-old chalazion patients and age- and sex-matched healthy controls were included into this retrospective case–control study. The peripheric blood sampling results obtained within six months from ophthalmological examination were investigated for statistical analysis. Free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), vitamin B12, vitamin D3, folic acid, and ferritin levels of the chalazion and control groups were compared.

Results

The male-to-female ratio was 8/28 in the chalazion group and 22/48 in the control group (p > 0.05). The mean age was 13.891 ± 3.924 years (3–17) and 12.346 ± 3.963 years (4–17) in the groups, respectively (p > 0.05). The mean time between ophthalmological examination and peripheric blood sampling was 3.012 ± 2.201 months (0–6) and 2.092 ± 1.906 months (0–6) in the groups, respectively (p > 0.05). The mean value of ferritin was 18.641 ± 8.971 μg/L (5.900–38.600) in the chalazion group and 35.455 ± 24.561 μg/L (11.850–106.100) in the control group (p = 0.019). The mean values of FT3, FT4, TSH, vitamin B12, vitamin D3, and folic acid levels were similar between the groups (p > 0.05 for all).

Conclusion

This study reports that pediatric chalazion patients have lower serum ferritin level than healthy children.
Literatur
1.
Zurück zum Zitat Bagheri A, Tavakoli M, Saloor H et al (2013) Epidemiology of eyelid skin masses over a 10- year period at Labbafinejad Medical Center. Bina J Ophthalmol 18:257–264 Bagheri A, Tavakoli M, Saloor H et al (2013) Epidemiology of eyelid skin masses over a 10- year period at Labbafinejad Medical Center. Bina J Ophthalmol 18:257–264
2.
Zurück zum Zitat Bagheri A, Hasani HR, Karimian F (2007) Effects of chalazion on refractive error and corneal topography. Bina J Ophthalmol 12:504–510 Bagheri A, Hasani HR, Karimian F (2007) Effects of chalazion on refractive error and corneal topography. Bina J Ophthalmol 12:504–510
3.
Zurück zum Zitat Ilhan C, Ozgul Yilmazoglu M, Yilmazbas P (2019) The effects of chalazion surgery on intraocular pressure and corneal topography. Int Ophthalmol 39:1055–1059CrossRef Ilhan C, Ozgul Yilmazoglu M, Yilmazbas P (2019) The effects of chalazion surgery on intraocular pressure and corneal topography. Int Ophthalmol 39:1055–1059CrossRef
4.
Zurück zum Zitat Chen L, Chen X, Xiang Q, Zheng Y, Pi L, Liu Q et al (2014) Prevalence of low serum vitamin a levels in young children with chalazia in Southwest China. Am J Ophthalmol 157:1103–1108CrossRef Chen L, Chen X, Xiang Q, Zheng Y, Pi L, Liu Q et al (2014) Prevalence of low serum vitamin a levels in young children with chalazia in Southwest China. Am J Ophthalmol 157:1103–1108CrossRef
5.
Zurück zum Zitat Alsammahi A, Aljohani Z, Jaad N, Abu Daia O, Aldayhum M, Almutairi M et al (2018) Incidence and predisposing factors of chalazion. Int J Community Med Public Health 5:4979–1982CrossRef Alsammahi A, Aljohani Z, Jaad N, Abu Daia O, Aldayhum M, Almutairi M et al (2018) Incidence and predisposing factors of chalazion. Int J Community Med Public Health 5:4979–1982CrossRef
8.
Zurück zum Zitat Malekahmadi M, Farrahi F, Tajdini A (2017) Serum Vitamin A Levels in Patients with Chalazion. Med Hypothesis Discov Innov Ophthalmol 6:63–66PubMedPubMedCentral Malekahmadi M, Farrahi F, Tajdini A (2017) Serum Vitamin A Levels in Patients with Chalazion. Med Hypothesis Discov Innov Ophthalmol 6:63–66PubMedPubMedCentral
9.
Zurück zum Zitat Goolamali SK, Evered D, Shuster S (1976) Thyroid disease and sebaceous function. BMJ 1:432–433CrossRef Goolamali SK, Evered D, Shuster S (1976) Thyroid disease and sebaceous function. BMJ 1:432–433CrossRef
10.
Zurück zum Zitat Bipat R, Jiawan D, Toelsie JR (2020) A case of recurrent Chalazia associated with subclinical hypothyroidism. Case Rep Ophthalmol 11:212–216CrossRef Bipat R, Jiawan D, Toelsie JR (2020) A case of recurrent Chalazia associated with subclinical hypothyroidism. Case Rep Ophthalmol 11:212–216CrossRef
11.
Zurück zum Zitat Hansson P, Valdemarsson S, Nilsson-Ehle P (1983) Experimental hyperthyroidism in man: effects on plasma lipoproteins, lipoprotein lipase and hepatic lipase. Horm Metab Res 15:449–452CrossRef Hansson P, Valdemarsson S, Nilsson-Ehle P (1983) Experimental hyperthyroidism in man: effects on plasma lipoproteins, lipoprotein lipase and hepatic lipase. Horm Metab Res 15:449–452CrossRef
12.
Zurück zum Zitat Nemet AY, Vinker S, Kaiserman I (2011) Associated Morbidity of Chalazia. Cornea 30:1376–1381CrossRef Nemet AY, Vinker S, Kaiserman I (2011) Associated Morbidity of Chalazia. Cornea 30:1376–1381CrossRef
13.
Zurück zum Zitat Brescoll J, Daveluy S (2015) A review of vitamin B12 in dermatology. Am J Clin Dermatol 16:27–33CrossRef Brescoll J, Daveluy S (2015) A review of vitamin B12 in dermatology. Am J Clin Dermatol 16:27–33CrossRef
14.
Zurück zum Zitat Jansen T, Romiti R, Kreuter A, Altmeyer P (2001) Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 15:484–485CrossRef Jansen T, Romiti R, Kreuter A, Altmeyer P (2001) Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 15:484–485CrossRef
15.
Zurück zum Zitat Ekiz Ö, Balta I, Şen BB, Dikilitaş MC, Özuguz PN, Rifaioglu EN (2013) Vitamin D status in patients with rosacea. Cutan Ocul Toxicol 33:60–62CrossRef Ekiz Ö, Balta I, Şen BB, Dikilitaş MC, Özuguz PN, Rifaioglu EN (2013) Vitamin D status in patients with rosacea. Cutan Ocul Toxicol 33:60–62CrossRef
16.
Zurück zum Zitat Antal AS, Dombrowski Y, Koglin S et al (2011) Impact of vitamin D3 on cutaneous immunity and antimicrobial peptide expression. Dermatoendocrinol 3:18–22CrossRef Antal AS, Dombrowski Y, Koglin S et al (2011) Impact of vitamin D3 on cutaneous immunity and antimicrobial peptide expression. Dermatoendocrinol 3:18–22CrossRef
17.
Zurück zum Zitat Akdogan N, Alli N, Incel Uysal P, Candar T (2019) Role of serum 25-hydroxyvitamin D levels and vitamin D receptor gene polymorphisms in patients with rosacea: a case-control study. Clin Exp Dermatol 44:397–403CrossRef Akdogan N, Alli N, Incel Uysal P, Candar T (2019) Role of serum 25-hydroxyvitamin D levels and vitamin D receptor gene polymorphisms in patients with rosacea: a case-control study. Clin Exp Dermatol 44:397–403CrossRef
18.
Zurück zum Zitat Greenberg JA, Bell SJ, Guan Y, Yu Y (2011) Folic acid supplementation and pregnancy: more than just neural tube defect prevention. Rev Obstet Gynecol 4:52–59PubMedPubMedCentral Greenberg JA, Bell SJ, Guan Y, Yu Y (2011) Folic acid supplementation and pregnancy: more than just neural tube defect prevention. Rev Obstet Gynecol 4:52–59PubMedPubMedCentral
19.
Zurück zum Zitat Sijilmassi O (2019) Folic acid deficiency and vision: a review. Graefes Arch Clin Exp Ophthalmol 257:1573–1580CrossRef Sijilmassi O (2019) Folic acid deficiency and vision: a review. Graefes Arch Clin Exp Ophthalmol 257:1573–1580CrossRef
20.
Zurück zum Zitat Tisma V, Basta-Juzbasic A, Jaganjac M, Brcic L, Dobric I, Lipozencic J, Tatzber F, Zarkovic N, Poljak-Blazi M et al (2009) Oxidative stress and ferritin expression in the skin of patients with rosacea. J Am Acad Dermatol 60:270–276CrossRef Tisma V, Basta-Juzbasic A, Jaganjac M, Brcic L, Dobric I, Lipozencic J, Tatzber F, Zarkovic N, Poljak-Blazi M et al (2009) Oxidative stress and ferritin expression in the skin of patients with rosacea. J Am Acad Dermatol 60:270–276CrossRef
21.
Zurück zum Zitat Elwan NM, Salah SM, Abdelsalam SF, Elfar NN (2020) Role of ferritin in pathogenesis of rosacea and its value in efficacy of 595 nm pulsed dye laser in treatment of different variants of rosacea: a clinical and immunohistochemical study. J Cosmet Laser Ther 22:130–136CrossRef Elwan NM, Salah SM, Abdelsalam SF, Elfar NN (2020) Role of ferritin in pathogenesis of rosacea and its value in efficacy of 595 nm pulsed dye laser in treatment of different variants of rosacea: a clinical and immunohistochemical study. J Cosmet Laser Ther 22:130–136CrossRef
22.
Zurück zum Zitat Vile GF, Tyrrell RM (2020) Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. J Biol Chem 268:14678–14681CrossRef Vile GF, Tyrrell RM (2020) Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. J Biol Chem 268:14678–14681CrossRef
23.
Zurück zum Zitat Vile GF, Basu-Modak S, Waltner C, Tyrrell RM et al (1994) Heme oxygenase-1 mediates an adaptive response to oxidative stress in human skin fibroblasts. Proc Natl Acad Sci USA 91:2607–2610CrossRef Vile GF, Basu-Modak S, Waltner C, Tyrrell RM et al (1994) Heme oxygenase-1 mediates an adaptive response to oxidative stress in human skin fibroblasts. Proc Natl Acad Sci USA 91:2607–2610CrossRef
Metadaten
Titel
Retrospective investigation of peripheric blood sampling in pediatric chalazion patients
verfasst von
Cagri Ilhan
Publikationsdatum
02.01.2021
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 4/2021
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-020-01680-2

Weitere Artikel der Ausgabe 4/2021

International Ophthalmology 4/2021 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Die Verwendung von Ophthalmika in der Schwangerschaft und Stillzeit stellt immer eine Off-label-Anwendung dar. Ein Einsatz von Arzneimitteln muss daher besonders sorgfältig auf sein Risiko-Nutzen-Verhältnis bewertet werden. In der vorliegenden …

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Vitrektomie Originalie

Die endogene Endophthalmitis ist eine hämatogen fortgeleitete, bakterielle oder fungale Infektion, die über choroidale oder retinale Gefäße in den Augapfel eingeschwemmt wird [ 1 – 3 ]. Von dort infiltrieren die Keime in die Netzhaut, den …

Bakterielle endogene Endophthalmitis

Vitrektomie Leitthema

Eine endogene Endophthalmitis stellt einen ophthalmologischen Notfall dar, der umgehender Diagnostik und Therapie bedarf. Es sollte mit geeigneten Methoden, wie beispielsweise dem Freiburger Endophthalmitis-Set, ein Keimnachweis erfolgen. Bei der …

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Die bestmögliche Wundheilung der Kornea, insbesondere ohne die Ausbildung von lichtstreuenden Narben, ist oberstes Gebot, um einer dauerhaften Schädigung der Hornhaut frühzeitig entgegenzuwirken und die Funktion des Auges zu erhalten.   

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.