Erschienen in:
01.04.2013 | Case Report
Reversible severe encephalitis and word deafness following rapid immune reconstitution in AIDS: a case report
verfasst von:
David Roh, Melanie D. Glenn, Carol K. Petito, M. Judith Donovan Post, Ashok Verma
Erschienen in:
Journal of NeuroVirology
|
Ausgabe 2/2013
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Excerpt
Combination antiretroviral therapy (cART) has dramatically reduced the occurrence of opportunistic infections (OI) and improved morbidity and mortality in patients with HIV infection. However, immunocompromised individuals who harbor OI and commence antiretroviral therapy (ART) are also susceptible to an enhanced immunological response to OI, called immune reconstitution inflammatory syndrome (IRIS) (French et al.
2000; Shelburne et al.
2002; Johnson and Nath
2011; del Amo et al.
2012; Post et al.
2013a; Müller et al.
2010). On occasion, IRIS can occur against HIV (Johnson and Nath
2011; Post et al.
2013b; Ringelstein et al.
2009), neoplastic (Müller et al.
2010) or autoantigens (Johnson and Nath
2011; Post et al.
2013b; Ringelstein et al.
2009). We report clinical, radiological, and neuropathological features of severe aseptic encephalitis heralding as an IRIS following cART in HIV infection. …
