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05.05.2022 | Review Article

Ribosomal proteins induce stem cell-like characteristics in glioma cells as an “extra-ribosomal function”

verfasst von: Takuichiro Hide, Ichiyo Shibahara, Madoka Inukai, Ryota Shigeeda, Yuki Shirakawa, Hirofumi Jono, Naoki Shinojima, Akitake Mukasa, Toshihiro Kumabe

Erschienen in: Brain Tumor Pathology | Ausgabe 2/2022

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Abstract

The characteristic features of plasticity and heterogeneity in glioblastoma (GB) cells cause therapeutic difficulties. GB cells are exposed to various stimuli from the tumor microenvironment and acquire the potential to resist chemoradiotherapy. To investigate how GB cells acquire stem cell-like phenotypes, we focused on ribosomal proteins, because ribosome incorporation has been reported to induce stem cell-like phenotypes in somatic cells. Furthermore, dysregulation of ribosome biogenesis has been reported in several types of cancer. We focused on ribosomal protein S6, which promotes sphere-forming ability and stem cell marker expression in GB cells. We expect that investigation of dysregulation of ribosome biogenesis and extra-ribosomal function in GB will provide new insights about the plasticity, heterogeneity, and therapeutic resistance of GB cells, which can potentially lead to revolutionary therapeutic strategies.

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Titel: Ribosomal proteins induce stem cell-like characteristics in glioma cells as an “extra-ribosomal function”
verfasst von: Takuichiro Hide
Ichiyo Shibahara
Madoka Inukai
Ryota Shigeeda
Yuki Shirakawa
Hirofumi Jono
Naoki Shinojima
Akitake Mukasa
Toshihiro Kumabe
Publikationsdatum: 05.05.2022
Verlag: Springer Nature Singapore
Erschienen in: Brain Tumor Pathology / Ausgabe 2/2022
Print ISSN: 1433-7398
Elektronische ISSN: 1861-387X
DOI: https://doi.org/10.1007/s10014-022-00434-5

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